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Anti-cell adhesion characteristics of nanotextured surface for implantable biomedical device

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Abstract

In this study, anti-cell adhesion characteristics of a nanotextured polymer surface prepared by a nano-imprint process were investigated by culturing NIH 3T3 fibroblast cells on the surface. The nanotextured surface, made of biocompatible polymer, was covered by nanodimples having a diameter of 220± 5 nm and inter-hole distance of 320 ± 5 nm. Migration of NIH 3T3 cells was confined within a small area, and cell aggregation was observed on the nanotextured surface. Aggregated cells were fully viable. On the other hand, NIH 3T3 cells cultured on a smooth surface actively migrated and eventually covered the entire surface area after 56 hours. Because the nanotextured surface displayed anti-cell adhesion characteristics without causing apoptosis, it can be used in implantable biomedical devices to confer anti-cell adhesion properties without any chemical treatment.

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Authors and Affiliations

  1. Department of Advanced Mechanical Engineering, Kangwon National University, 1, Gangwondaehak-gil, Chuncheon, Gangwon-do, 24341, South Korea

    Eui Don Han, Byeong Hee Kim & Young Ho Seo

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  1. Eui Don Han
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  2. Byeong Hee Kim
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  3. Young Ho Seo
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Correspondence to Young Ho Seo.

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Han, E.D., Kim, B.H. & Seo, Y.H. Anti-cell adhesion characteristics of nanotextured surface for implantable biomedical device. Int. J. Precis. Eng. Manuf. 18, 239–244 (2017). https://doi.org/10.1007/s12541-017-0031-6

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  • DOI: https://doi.org/10.1007/s12541-017-0031-6

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