The authors thank the participants for their valuable contribution to the VISIONARY study.
Sponsorship for this study, publication fees (Rapid Service and Open Access), and medical writing fees were provided by Santen SA. The contribution of IRCCS Fondazione Bietti to this work was supported by the Italian Ministry of Health and by Fondazione Roma.
Medical Writing and Other Assistance
Claudia Fassari, Feride Sahin and Gabriela Saborio provided input concerning the design and implementation of the study as well as the analyses and reporting of data on behalf of Santen. Claire Lea also provided input and guidance on the reporting of scientific data on behalf of Santen. Medical writing services were provided on behalf of the authors by Rebecca Down at Copperfox Communications Limited.
All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.
Francesco Oddone, James Kirwan, Fernando Lopez-Lopez, Marina Zimina and Gábor Holló were Principal Investigators on the VISIONARY study and were responsible for the reporting of patient data, along with those authors listed in the VISIONARY study group (below). Francesco Oddone and Gábor Holló were also instrumental in the study analysis and drafting of the manuscript. Claudia Fassari was instrumental in the study design, analysis and drafting of the manuscript. Francesco Oddone, James Kirwan, Fernando Lopez-Lopez, Marina Zimina, Claudia Fassari and Gábor Holló reviewed and commented on the data reported herein and all authors approved the final manuscript.
VISIONARY Study Group Principal Investigators
Austria: Christoph Faschinger (LKH—Universitaetsklinikum Graz); Sweden: Enping Chen (St Eriks Eye Clinic, Stockholm); Hungary: Gábor Holló (Semmelweis University, Budapest), Gabor Nemeth (Borsod-Abaúj-Zemplén Megyei Kórház Szemészeti Miskolc), Gyorgy Bator (Markusovszky Egyetemi OktatóKórház, Szombathely), Alexis Tsorbatzoglou (Szabolcs-Szatmár-Bereg County Hospital and University Teaching Hospital, Nyíregyháza),Tamas Acs (Bács-Kiskun Megyei Kórház, Kecskemét), Maria Ferencz (Szent Imre Egyetemi Oktatkórház, Budapest), Zoltán Sohajda (Kenézy Gyula Kórház és Rendelőintéze, Debrecen), Jeno Toth (Fejér Megyei Szent György Egyetemi Oktató Kórház, Székesfehérvár), Veronika Volner (Uzsoki Utcai Kórház, Budapest), Gábor Vogt (Magyar Honvédség Egészségügyi Központ, Budapest), Zsolt Biro (PTE- Szemészeti Klinika, Pécs), Andrea Facskó (Szegedi Tudomá nyegyetem Szent-Györgyi Albert Klinikai Központ, Szent-Győrgy), János Nemes (Megyei Flór Ferenc Kórház, Kistarcsa), Andras Berta (University of Debrecen, Debrecen), Ilona Elek (Bugát Pál Kórház, Győngyős); Ireland: Eugene Ng (The Whitfield Clinic Butlerstown, Waterford); Italy: Francesco Oddone (IRCSS-Fondazione Bietti, Roma), Gemma Rossi (IRCCS-Fondazione Policlinico San Matteo, Pavia), Luca Rossetti (Ospedaliera San Paolo, Milan), Michele Vetrugno (Università di Bari, Bari), Michele Iester (Eye Clinic, DiNOGMI, University of Genoa, Ospedale Policlinico San Martino, Genoa, Genoa), Giorgio Marchini (Ospedale Civile Maggiore Borgo Trento, Verona), Vincenzo Scorcia (Università degli studi Magna Græcia, Catanzaro), Giovanni Staurenghi (Ospedale Luigi Sacco, Milano), Carlo Cagini (Università degli Studi di Perugia, Perugia), Tommaso Salgarello (Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma), Paolo Bettin (IRCCS Ospedale San Raffaele, Milano), Michele Figus (Ospedale Cisanello, Pisa), Gian Luca Scuderi (Ospedale Sant’Andrea, Roma), Stefano De Cilla (Azienda Ospedaliera Universitaria Maggiore della Carita Presidio Ospedaliero San Rocco, Novara); Latvia: Iveta Grundmane (Grund-opt Ltd, Valmiera), Nora Linavska (LENS-L Ltd, Liepaja), Lasma Volksone (Lavolks Ltd, Riga), Guna Laganovska (P. Stradiņš Clinical University Hospital, Riga), Kristine Baumane (Riga East Clinical University Hospital, Riga); Netherlands: Hans Lemij (Rotterdam Ophthalmic Institute, Rotterdam); Norway: Kjell Gunnar Gundersen (Dr Kjell Gunnar Gundersen MD, Haugesund); Russia: Marina Zimina (LLC Vzglyad, Leningradskaya), Valery Erichev (Federal State Budgetary Scientific Institution Scientific, Research Institute of Eye Diseases, Moscow), Elmira Adbulaeva (State Autonomous Institution of Healthcare Republican Clinical Ophthalmological Hospital of the Ministry of Healthcare of the Republic of Tatarstan, Republic of Tatarstan), Elena Karlova (State Budgetary Institution of Healthcare Samara Regional Clinical Ophthalmological Hospital, Samara), Ekaterina Zakharova (RKOB Sverdlova, Yakutsk), Irina Panova (S. Fyodorov Eye Microsurgery Federal State Institution, Saint Petersburg), Boris Malyugin (Sv. Fyodorov’s Eye Microsurgery Complex, Moscow); Spain: Iñaki Rodríguez-Agirretxe (H.U. Donostia, Guipuzcoa), Fernando Lopez-Lopez (Instituto Oftalmologico Gomez-Ulla, Galicia), Antonio Moreno Valladares (Hospital Ntra. Sra. del Perpetuo Socorro, Albacete), Javier Benitez del Castillo (Hospital Universitario de Jerez, Cadiz), Rafael Gimenez (Hospital Reina Sofia, Cordoba), Maria Parrilla Vallejo (Hospital La Macarena, Seville), Jose Javier Garcia-Medina (Hospital General Universitario Morales Meseguer, Murcia), Alfonso Anton Lopez (Institut Catalá de Retina, Barcelona), Sergio Torregrosa (Hospital Punta de Europa, Cadiz), Jorge Loscos (Hospital German Trias I Pujol, Barcelona); Denmark: Miriam Kolko (Rigshospitalet Valdemar Hansensvej, Glostrup); UK: Ejaz Ansari (Maidstone and Tunbridge Wells NHS Trust, Canterbury Christ Church University, Kent), David Broadway (Norfolk and Norwich University Hospital, Norwich, Norfolk), Katharine Claridge (Royal Cornwall Hospital, Truro, Cornwall), Simon Ruben (Southend University Hospital NHS Foundation Trust, Westcliff-On-Sea, Essex), James Kirwan (Queen Alexandra Hospital, Portsmouth Hospitals NHS Trust, Portsmouth, Hampshire), Anca Nita (Royal Victoria Infirmary, The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne), Michael Smith (Royal Devon & Exeter NHS Foundation Trust, Exeter, Devon), Areeb Moosavi (Milton Keynes University Hospital NHS Foundation Trust, Milton Keynes), Anthony JW King (Nottingham University Hospitals NHS Trust, Nottingham), Matthew Kinsella (Buckinghamshire Healthcare NHS Trust, Stoke Mandeville Hospital, Buckinghamshire).
Francesco Oddone has received consultancy fees from Santen, Allergan, Sooft, Omikron Italia and Centervue. and Novartis. James Kirwan has not received consulting fees in the last 3 years. In the last 5 years Mr Kirwan has received lecture fees from Thea, Santen and Aspire and consulting fees from Aspire and Santen. Fernando Lopez-Lopez and Marina Zimina have no relevant disclosures. Claudia Fassari is an employee of Santen SA. Gábor Holló has received consultancy and lecturing fees from Santen and Aerie.
Compliance with Ethics Guidelines
The study was registered under the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance (ENCePP®) European Union electronic Register of Post-Authorisation Studies (EU PAS Register) (EU PAS register number: EUPAS22204) and complied with the principles of the Declaration of Helsinki of 1964 as revised in 2013. All patients included were required to provide written informed consent prior to their enrolment. The study protocol was approved by the Institutional Review Board (IRB) or Independent Ethics Committee (IEC) at each center/institution and written informed consent was obtained from subjects prior to enrolment. Each of the study centers/institutions are listed in the Acknowledgments alongside the relevant Principal Investigator.
The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.