Abstract
To study the role of the absolute lymphocyte count (ALC), absolute monocyte count (AMC), platelet count (PLT), lymphocyte–monocyte ratio (LMR) and the platelet–lymphocyte ratio (PLR) in the prognosis of primary gastrointestinal diffuse large B cell lymphoma (PGI-DLBCL). We retrospectively analyzed the prognostic value of the ALC, AMC, PLT, LMR, PLR at diagnosis in 173 PGI-DLBCL patients through histopathological examination from March 2009 to February 2015. In total, 173 patients with histopathological diagnosis of PGI-DLBCL in this study, the median age was 51 years (range 12–90 years), median follow-up time was 44 months (range 7–89 months). In univariate analysis, age <60 years, B symptoms, Lugano stage I–II, low international prognostic index (IPI) or low age-adjusted international prognostic index (aaIPI), normal lactate dehydrogenase (LDH), normal β2-microglobulin (β2m), Hb ≥ 11 g/dL, ALC ≥ 1.5 × 109/L, AMC ≤ 0.50 × 109/L, LMR ≥ 2.5, PLR ≤ 170 were related with superior overall survival (OS) and progression-free survival (PFS) (p ≤ 0.05). Multivariate analysis suggested that ALC, LMR, LDH were related with PFS (p ≤ 0.05). Similarly, age and LMR were related with OS (p ≤ 0.05). The parameters (ALC, AMC, LMR, PLR) may be valuable prognostic factors in PGI-DLBCL patients. LMR, PLR at diagnosis are expected to be independent prognostic factors for PGI-DLBCL patients.
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Acknowledgments
I would like to express my gratitude to all those who helped me during the writing of this thesis. I gratefully acknowledgement the help of my supervisor, Dr. Xiaofang Wang, for her constant encouragement and guidance. Also, I owe much to Miss Li Zang for her valuable suggestion and critiques which are of help and important in making the thesis a reality. This research was supported by grants from the National Natural Science Foundation of China (No. 81272562).
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This study was funded by the National Natural Science Foundation of China (Grant Number 81272562).
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.
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Zhao, P., Zang, L., Zhang, X. et al. The Lymphocyte–Monocyte Ratio and the Platelet–Lymphocyte Ratio at Diagnosis as Independent Prognostic Factors in Primary Gastrointestinal Diffuse Large B Cell Lymphoma. Indian J Hematol Blood Transfus 33, 333–341 (2017). https://doi.org/10.1007/s12288-016-0720-9
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DOI: https://doi.org/10.1007/s12288-016-0720-9