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Radioiodinated tyrosine based carbon dots with efficient renal clearance for single photon emission computed tomography of tumor

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Abstract

Nanoparticles with effective tumor accumulation and efficient renal clearance have attracted significant interests for clinical applications. We prepared 2.5 nm tyrosine based carbon dots (TCDs) with phenolic hydroxyl groups on the surface for directly 125I labeling. The 125I labeled polyethylene glycol (PEG) functionalized TCDs (125I-TCDPEGs) showed excellent radiochemical stability both in vitro and in vivo. Due to the enhanced permeability and retention effect, these 125I-TCDPEGs demonstrated a tumor accumulation around 4%–5% of the injected dose per gram (ID/g) for U87MG, 4T1, HepG2 and MCF7 tumor-bearing mice at 1 h post-injection. Meanwhile, the 125I-TCDPEGs also could be fast renally excreted, with less than 0.6% ID/g left in the liver and spleen within 24 h. These radioactive carbon dots not only can be used for cellular fluorescence imaging due to their intrinsic optical property, but are also effective single photon emission computed tomography (SPECT) imaging agents for tumor. Together with their excellent biocompatibility and stability, we anticipate these 125I-TCDPEGs of great potential for early tumor diagnosis in clinic. What’s more, our TCDPEGs are also proved to be feasible carriers for other iodine isotopes such as 127I and 131I for different biomedical application.

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Acknowledgements

X. S. acknowledges the National Key Research and Development Program of China (No. 2016YFA0203600), the National Natural Science Foundation of China (Nos. 81971738 and 81571743), the Project Program of State Key Laboratory of Natural Medicines, and the China Pharmaceutical University (No. SKLNMZZRC05).

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  1. Nian Liu and Yiyue Shi contributed equally to this work.

Authors and Affiliations

  1. State Key Laboratory of Natural Medicines, Key Laboratory of Drug Quality Control and Pharmacovigilance, Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, 210009, China

    Nian Liu, Yiyue Shi, Jingru Guo & Xiaolian Sun

  2. Institute of Biological and Medical Imaging, Helmholtz Zentrum München and Technische Universität München, Neuherberg, 85764, Germany

    Nian Liu

  3. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361005, China

    Nian Liu, Menglin Song & Zhiyuan Shi

  4. Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, 215123, China

    Hai Li & Le He

  5. Department of Nuclear Medicine, Zhongshan Hospital Xiamen University, Xiamen, 361004, China

    Qiang Wang & Xinhui Su

  6. Department of Chemistry, Bio-Imaging Research Center, University of Georgia, Athens, Georgia, 30602, USA

    Jin Xie

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  1. Nian Liu
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Correspondence to Xiaolian Sun.

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Radioiodinated tyrosine based carbon dots with efficient renal clearance for single photon emission computed tomography of tumor

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Liu, N., Shi, Y., Guo, J. et al. Radioiodinated tyrosine based carbon dots with efficient renal clearance for single photon emission computed tomography of tumor. Nano Res. 12, 3037–3043 (2019). https://doi.org/10.1007/s12274-019-2549-7

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