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Small-molecule diketopyrrolopyrrole-based therapeutic nanoparticles for photoacoustic imaging-guided photothermal therapy

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Abstract

Therapeutic nanoparticles (NPs) based on the donor–acceptor–donor structured small organic molecule diketopyrrolopyrrole (SDPP) were prepared using a simple reprecipitation approach. These near-infrared radiation-absorbing NPs have high photothermal conversion efficiency and are able to selectively target cancer tissues through the enhanced permeability and retention effect. Benefiting from these advantages, SDPP NPs can serve as an excellent therapeutic agent for highly efficient and noninvasive photoacoustic imaging-guided photothermal therapy. Experiments using mouse tumor models showed that the SDPP NPs exhibited exceptional tumor ablation ability under laser irradiation (660 nm, 1.0 W·cm‒2), even at a low dose (0.16 mg·kg‒1).

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Acknowledgements

The work was supported by the National Basic Research Program of China (No. 2014CB660808), the National Natural Science Foundation of China (Nos. 61525402 and 21275076), Key University Science Research Project of Jiangsu Province (No. 15KJA430006), Program for New Century Excellent Talents in University (No. NCET-13-0853), QingLan Project, Jiangsu Province Science Foundation for Six Great Talent Peak (No. XCL-018).

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Authors and Affiliations

  1. Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, 211816, China

    Yu Cai, Weili Si, Qianyun Tang, Pingping Liang, Chengwu Zhang, Wei Huang & Xiaochen Dong

  2. School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, N1.3-B3-08, Singapore, Singapore

    Peng Chen

  3. School of Pharmaceutical Sciences, Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, 211816, China

    Qi Zhang

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  1. Yu Cai
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  2. Weili Si
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  3. Qianyun Tang
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  4. Pingping Liang
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  5. Chengwu Zhang
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  6. Peng Chen
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  7. Qi Zhang
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  9. Xiaochen Dong
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Correspondence to Qi Zhang, Wei Huang or Xiaochen Dong.

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These authors contributed equally to this work.

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Small-molecule diketopyrrolopyrrole-based therapeutic nanoparticles for photoacoustic imaging-guided photothermal therapy

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Cai, Y., Si, W., Tang, Q. et al. Small-molecule diketopyrrolopyrrole-based therapeutic nanoparticles for photoacoustic imaging-guided photothermal therapy. Nano Res. 10, 794–801 (2017). https://doi.org/10.1007/s12274-016-1332-2

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  • DOI: https://doi.org/10.1007/s12274-016-1332-2

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