Nano Research

, Volume 1, Issue 2, pp 99–115 | Cite as

Bioconjugated silica nanoparticles: Development and applications

  • Lin Wang
  • Wenjun Zhao
  • Weihong Tan
Open Access
Review Article


Advanced bioanalysis, including accurate quantitation, has driven the need to understand biology and medicine at the molecular level. Bioconjugated silica nanoparticles have the potential to address this emerging challenge. Particularly intriguing diagnostic and therapeutic applications in cancer and infectious disease as well as uses in gene and drug delivery, have also been found for silica nanoparticles. In this review, we describe the synthesis, bioconjugation, and applications of silica nanoparticles in different bioanalysis formats, such as selective tagging, barcoding, and separation of a wide range of biomedically important targets. Overall, we envisage that further development of these nanoparticles will provide a variety of advanced tools for molecular biology, genomics, proteomics and medicine.


Nanoscience nanotechnology silica nanoparticles bioanalysis biomedicine 

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Copyright information

© Tsinghua Press and Springer-Verlag GmbH 2008

Authors and Affiliations

  1. 1.Lilly Research LaboratoriesEli Lilly and CompanyIndianapolisUSA
  2. 2.Chinese Academy of Inspection and QuarantineBeijingChina
  3. 3.Center for Research at the Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain InstituteUniversity of FloridaGainesvilleUSA

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