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FloDots: luminescent nanoparticles

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Abstract

Luminescent dye-doped silica nanoparticles (FloDots) have been developed for ultrasensitive bioanalysis and diagnosis in the past several years. Those novel nanoparticles are highly luminescent and extremely photostable. In this paper, we review the preparation, characterization, bioconjugation and bioapplication of FloDots. All the results clearly demonstrated that FloDots have many advantages over currently used luminescent probes, such as traditional fluorophores and quantum dots.

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Acknowledgements

We thank our colleagues at the University of Florida for their help with the work reported in this manuscript. This work was supported by NIH grants and NSF NIRT.

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Authors and Affiliations

  1. Center for Research at the Bio/nano Interface, Department of Chemistry and Shands Cancer Center, University of Florida, Gainesville, FL, 32611-7200, USA

    Gang Yao, Lin Wang, Yanrong Wu, Josh Smith, Wenjun Zhao, Eunjung Lee & Weihong Tan

  2. Life Science Inc., 2900 72nd Street North, St. Petersburg, FL, 33710, USA

    Gang Yao

  3. Department of Chemistry, Hengyang Normal University, Hengyang, Hunan, 421008, People’s Republic of China

    Jinsheng Xu

Authors
  1. Gang Yao
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  2. Lin Wang
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  3. Yanrong Wu
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  4. Josh Smith
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  5. Jinsheng Xu
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  6. Wenjun Zhao
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  7. Eunjung Lee
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  8. Weihong Tan
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Corresponding author

Correspondence to Weihong Tan.

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Yao, G., Wang, L., Wu, Y. et al. FloDots: luminescent nanoparticles. Anal Bioanal Chem 385, 518–524 (2006). https://doi.org/10.1007/s00216-006-0452-z

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