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Polymeric vehicles for topical delivery and related analytical methods

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Abstract

Recently a variety of polymeric vehicles, such as micelles, nanoparticles, and polymersomes, have been explored and some of them are clinically used to deliver therapeutic drugs through skin. In topical delivery, the polymeric vehicles as drug carrier should guarantee non-toxicity, long-term stability, and permeation efficacy for drugs, etc. For the development of the successful topical delivery system, it is of importance to develop the polymeric vehicles of well-defined intrinsic properties, such as molecular weights, HLB, chemical composition, topology, specific ligand conjugation and to investigate the effects of the properties on drug permeation behavior. In addition, the role of polymeric vehicles must be elucidated in in vitro and in vivo analyses. This article describes some important features of polymeric vehicles and corresponding analytical methods in topical delivery even though the application span of polymers has been truly broad in the pharmaceutical fields.

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Abbreviations

ASMs:

Amphiphilic star-like macromolecules

BSA:

Bovine serum albumin

CAB:

Cellulose acetate butyrate

CBZ:

Carbamazepine

CLSM:

Confocal laser scanning microscopy

CAC:

Critical aggregation concentration

CMC:

Critical micelle concentration

CsA:

Cyclosporin A

DEE:

Drug encapsulation efficiency

DTO–SA:

Desaminotyrosyl tyrosine octyl esters–suberic diacids

EPM:

Enalapril maleate

FDC:

Franz diffusion cell

FITC:

Fluorescein isothiocyanate

HDV:

Hydrodynamic volume

HEMA:

2-Hydroxyethyl methacrylate

HLB:

Hydrophile–lipophile balance

HPLC:

High performance liquid chromatography

LRP:

Living radical polymerization

MAMA:

9-(Methylaminomethyl)anthracene

Mn:

The number average molecular weight

MW:

Molecular weight

Nagg :

Aggregation number

NR:

Nile red, dye

NSAID:

Non-steroidal anti-inflammatory drugs

OMC:

Octyl methoxycinnamate

PAMAM:

Polyamidoamine

PAsn-g-PCL:

Poly(aspargine)-graft-poly(caprolactone)

PCL:

Poly(ε-caprolactone)

PEEP–PCL–PEEP:

Poly(ethyl ethylene phosphate)–poly(E-caprolactone)–poly(ethyl ethylene phosphate)

PEG:

Poly(ethylene glycol)

PGA:

Poly(glycolic acid)

PHB:

Polyhydroxybutyrate

PLA:

Poly(lactic acid)

PLGA:

Poly(lactic-co-glycolic acid)

PMM:

Poly(methylidene malonate)

PPG:

Poly(propylene glycol)

PPO:

Polypropylene oxide

PS:

Poly(styrene)

PTX:

Paclitaxel

ROP:

Ring opening polymerization

SC:

Stratum corneum

SDS:

Sodium dodecyl sulfate

Sn(Oct)2 :

Stannous octoate

ST:

Styrene

TEWL:

Transdermal water loss

VE:

Viable epidermis

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Acknowledgments

This study was supported by Kyungpook National University Research Fund, 2011.

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The authors declare no conflict of interest.

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Authors and Affiliations

  1. Cosmetic Research Center, Coway Co. Ltd., 459-11 Gasan-dong, Geumcheon-gu, Seoul, South Korea

    Heui Kyoung Cho & Jin Hun Cho

  2. College of Pharmacy, Dongguk University, Seoul, Gyeonggi, 410-820, South Korea

    Seong Hoon Jeong

  3. Department of Applied Chemistry, Kyungpook National University, 80 Daehak-ro, Buk-gu, Taegu, 702-701, South Korea

    Dong Chul Cho, Jeong Hyun Yeum & In Woo Cheong

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  1. Heui Kyoung Cho
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  2. Jin Hun Cho
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  3. Seong Hoon Jeong
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  4. Dong Chul Cho
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  6. In Woo Cheong
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Correspondence to In Woo Cheong.

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Cho, H.K., Cho, J.H., Jeong, S.H. et al. Polymeric vehicles for topical delivery and related analytical methods. Arch. Pharm. Res. 37, 423–434 (2014). https://doi.org/10.1007/s12272-014-0342-4

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  • DOI: https://doi.org/10.1007/s12272-014-0342-4

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