Abstract
Diterpenes constitute a versatile class of natural biomolecules predominantly derived from plants, fungi and prokaryotes. Properties of these natural products include anti-tumour, anti-inflammatory, antibiotic, and insecticidal activities, which makes these compounds high value commercial targets for the chemical and pharmaceutical industry. Since chemical synthesis of terpenes can be difficult, production can be alternatively performed in engineered microorganisms on natural occurring routes.
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Literatur
Christianson DW (2008) Unearthing the roots of the terpenome. Curr Opin Chem Biol 12:141–150
Kemper K, Hirte M, Reinbold M et al. (2017) Opportunities and challenges for the sustainable production of structurally complex diterpenoids in recombinant microbial systems. Beilstein J Org Chem 13:845–854
Brück T, Kourist R, Loll B (2014) Production of macrocyclic sesqui- and diterpenes in heterologous microbial hosts: a systems approach to harness nature’s molecular diversity. ChemCatChem, doi: 101002/cctc201300733
Köksal M, Jin Y, Coates RM et al. (2011) Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis. Nature 469:116–120
Nicolaou KC, Yang Z, Liu JJ et al. (1994) Total synthesis of taxol. Nature 367:630–634
Janke R, Görner C, Hirte M et al. (2014) The first structure of a bacterial diterpene cyclase: CotB2. Acta Crystallogr D Biol Crystallogr 70:1528–1537
Boghigian BA, Salas D, Ajikumar PK et al. (2012) Analysis of heterologous taxadiene production in K- and B-derived Escherichia coli. Appl Microbiol Biotechnol 93:1651–1661
Yuan C, Jin Y, Wilde NC et al. (2016) Short, enantioselective total synthesis of highly oxidized taxanes. Angew Chem Int Ed Engl 55:8280–8284
Christmann M (2008) Selective oxidation of aliphatic C-H bonds in the synthesis of complex molecules. Angew Chem Int Ed Engl 47:2740–2742
Görner C, Häuslein I, Schrepfer P et al. (2013) Targeted engineering of cyclooctat-9-en-7-ol synthase: a stereospecific access to two new, non-natural fusicoccane-type diterpenes. ChemCatChem, doi: 10.1002/cctc.201300285
Görner C, Schrepfer P, Redai V et al. (2016) Identification, characterization and molecular adaptation of class I redox systems for the production of hydroxylated diterpenoids. Microb Cell Fact 15:86
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Janke, R., Fuchs, M., Christmann, M. et al. Herstellung von polyzyklischen Diterpenen. Biospektrum 23, 709–711 (2017). https://doi.org/10.1007/s12268-017-0858-5
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DOI: https://doi.org/10.1007/s12268-017-0858-5