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Autonomic Disturbances in Acute Cerebrovascular Disease

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Abstract

Autonomic disturbances often occur in patients with acute cerebrovascular disease due to damage of the central autonomic network. We summarize the structures of the central autonomic network and the clinical tests used to evaluate the functions of the autonomic nervous system. We review the clinical and experimental findings as well as management strategies of post-stroke autonomic disturbances including electrocardiographic changes, cardiac arrhythmias, myocardial damage, thermoregulatory dysfunction, gastrointestinal dysfunction, urinary incontinence, sexual disorders, and hyperglycemia. The occurrence of autonomic disturbances has been associated with poor outcomes in stroke patients. Autonomic nervous system modulation appears to be an emerging therapeutic strategy for stroke management in addition to treatments for sensorimotor dysfunction.

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Acknowledgements

This review was supported partly by grants from the National Institutes of Health, USA (NS081740 and NS082184).

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Authors and Affiliations

  1. Department of Neurosurgery, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, 322000, China

    Jun Mo

  2. Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA, 92350, USA

    Jun Mo, Lei Huang, Jianhua Peng, Umut Ocak & John H. Zhang

  3. Department of Neurosurgery, Loma Linda University, Loma Linda, CA, 92350, USA

    Lei Huang & John H. Zhang

  4. Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310000, China

    Jianmin Zhang

  5. Brain Research Institute, Zhejiang University, Hangzhou, 310000, China

    Jianmin Zhang

  6. Collaborative Innovation Center for Brain Science, Zhejiang University, Hangzhou, 310000, China

    Jianmin Zhang

  7. Department of Anesthesiology, Loma Linda University, Loma Linda, CA, 92350, USA

    John H. Zhang

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  1. Jun Mo
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Mo, J., Huang, L., Peng, J. et al. Autonomic Disturbances in Acute Cerebrovascular Disease. Neurosci. Bull. 35, 133–144 (2019). https://doi.org/10.1007/s12264-018-0299-2

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