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Peptides conjugation on biomaterials: chemical conjugation approaches and their promoted multifunction for biomedical applications

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Abstract

Researchers have made significant efforts to attach peptides to various biomaterials, resulting in diverse functionalities. By harnessing the advantages of peptides, functions such as high specificity, potency, cost-effectiveness, small size for improved tissue penetration and targeted delivery, biodegradability, and novel therapeutic applications can be achieved through their attachment to biomaterials. Of various methods available for modifying biomolecules, chemical techniques are the most established and can effectively immobilize the desired molecule onto a specific surface. This article provides a comprehensive overview of the chemical modification methods used for attaching peptides to various biomaterials in recent studies and showcases some of their latest applications.

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Fig. 1

Copyright permission granted by John Wiley and Sons. B pH-responsive PEPc–PMAA peptide–polymer conjugates [42]. Copyright permission granted by the American Chemical Society. C Star-shaped peptide–PEG hybrid polymers and their self-assembly to produce pH-responsive hydrogels [43]. Copyright permission granted by the American Chemical Society

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Funding

This research was supported by the Chung-Ang University Research Scholarship Grants in 2022 (Mr. Jongjun Park). This research was also supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. RS-2023–00275006 and No. RS-2023-00211253).

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Authors and Affiliations

  1. School of Integrative Engineering, Chung-Ang University, Seoul, 06974, Republic of Korea

    Jiwon Kim, Yonghyun Choi, Jongjun Park & Jonghoon Choi

  2. Feynman Institute of Technology, Nanomedicine Corporation, Seoul, 06974, Republic of Korea

    Yonghyun Choi & Jonghoon Choi

  3. Department of Chemical Science and Engineering, Tokyo Institute of Technology, 4259 Nagatsuta-Cho, Midori-Ku, Yokohama-Shi, Kanagawa, 226-8503, Japan

    Yonghyun Choi

  4. Department of Chemical Engineering, Kumoh National Institute of Technology, Gumi-Si, 39177, Republic of Korea

    Hee-Young Lee

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  1. Jiwon Kim
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  2. Yonghyun Choi
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  4. Hee-Young Lee
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Contributions

JC and HYL supervised the study. JK, JP, and YC designed the study and performed the literature survey. JK, YC, JP, HYL, and JC wrote the manuscript.

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Correspondence to Hee-Young Lee or Jonghoon Choi.

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Conflict of Interest

Dr. Jonghoon Choi is the CEO/Founder, and Dr. Yonghyun Choi is the CTO of Feynman Institute of Technology at the Nanomedicine Corporation, Seoul, 06974, Republic of Korea.

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Kim, J., Choi, Y., Park, J. et al. Peptides conjugation on biomaterials: chemical conjugation approaches and their promoted multifunction for biomedical applications. Biotechnol Bioproc E (2024). https://doi.org/10.1007/s12257-024-00095-5

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