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Thermoresponsive, dually cross-linked elastin-like-polypeptide (ELP) micelle hydrogel with recovery properties

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Abstract

Thermoresponsive protein-based hydrogels have been widely used due to their high potential in biomedical fields. Elastin-like polypeptides (ELPs) are one of the proteins that show lower critical solution temperature (LCST) behavior, resulting in self-assembly above critical micellular temperature (CMT). Here, we utilized ABC-type blocky ELPs to form hydrogels by introducing cross-linking sites, resulting in good mechanical properties. The hydrogels showed temperature-dependent viscoelasticity due to their structure change. Also, the recovery process of ELP-based hydrogels after large deformation is significantly dependent on the types of cross-linking (i.e., ionic, covalent, or ionic-covalent hybrid).

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Acknowledgements

This work was supported by grants (2018R1D1A1B07041887) and (2021R1A2C2011164) from the National Research Foundation of Korea.

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Authors and Affiliations

  1. Department of Chemical Engineering, Hongik University, Seoul, 04066, Korea

    Jongsoo Choi, Moon-Chul Ryu, Jae Jung Kim, Soo-Hyung Choi & Jong-In Won

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  1. Jongsoo Choi
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  2. Moon-Chul Ryu
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  3. Jae Jung Kim
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  4. Soo-Hyung Choi
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  5. Jong-In Won
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Correspondence to Jong-In Won.

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Choi, J., Ryu, MC., Kim, J.J. et al. Thermoresponsive, dually cross-linked elastin-like-polypeptide (ELP) micelle hydrogel with recovery properties. Korean J. Chem. Eng. 40, 1954–1962 (2023). https://doi.org/10.1007/s11814-023-1473-4

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  • DOI: https://doi.org/10.1007/s11814-023-1473-4

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