Abstract
A 59-year-old patient presented in the outpatient clinic because of an increasing mass in his right buttock. He has a history of a testicular tumor 28 years ago, with increased tumor markers (Human Choriongonadotropin (β-HCG) value 4.9 and Alpha-1 Fetoprotein (AFP) 218 ng/ml).
Similar content being viewed by others
References
Collins DH, Pugh RC. Classification and frequency of testicular tumours. Br J Urol. 1964;36:1–11.
Winter E, Kliesch S, Souchon R, de Maike W. Diagnosis of testicular cancer. Dtsch Arztebl. 2005;102:A 3021–5 (Heft 44).
Ulbright TM. Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues. Mod Pathol. 2005;18 Suppl 2:S61–79.
Stamatiou K, Papadopoulos P, Perlepes G, Galariotis N, Olympitis M, Moschouris H, Vasilakaki T. Mixed germ tumor of the testicle with ravdomuosarcomatous component: a case report. Cases J. 2009;2:9299.
Krege S, et al. European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus Group (EGCCCG): part I. Eur Urol. 2008;53(3):478–96.
Hanna NH, Einhorn LH. Testicular cancer—discoveries and updates. N Engl J Med. 2014;371:2005–16.
Krege S, Albers P, Schmidberger H. Treatment of non-metastatic and moderate metastatic testicular cancer. Dtsch Arztebl. 2005;102:A 3191–4 (Heft 46).
Bokemeyer C, Beyer J, Heidenreich A. Treatment of patients with metastatic germ cell tumors. Dtsch Arztebl. 2005;102:A 3271–5 (Heft 47).
Pottek TS, Hartmann M, Bokemeyer C. Aftercare and delayed toxicity of testicular cancer. Dtsch Arztebl. 2005;102:A 3342–8 (Heft 48).
Gerl A, Clemm C, Schmeller N, Hentrich M, Lamerz R, Wilmanns W. Late relapse of germ cell tumors after cisplatin-based chemotherapy. Ann Oncol. 1997;8(1):41–7.
Oldenburg J, Alfsen GC, Waehre H, Fossá SD. Late recurrences of germ cell malignancies: a population-based experience over three decades. Br J Cancer. 2006;94(6):820–7.
Geldart TR, Gale J, McKendrick J, Kirby J, Mead G. Late relapse of metastatic testicular nonseminomatous germ cell cancer: surgery is needed for cure. BJU Int. 2006;98(2):353–8.
Ronnen EA, Kondagunta GV, Bacik J, Marion S, Bajorin DF, Sheinfeld J, Bosl GJ, Motzer RJ. Incidence of late-relapse germ cell tumor and outcome to salvage chemotherapy. J Clin Oncol. 2005;23(28):6999–7004.
Krege S, et al. European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus Group (EGCCCG): part II. Eur Urol. 2008;53(3):497–513.
Arafat W, Albany C, Ulbright TM, Foster R, Einhorn LH. Very late relapse of germ cell tumor as a teratoma: a case report and review of the literature. J Surg Case Rep. 2014;2014(6):rju051.
Pavic M, Meeus P, Treilleux I, Droz JP. Malignant teratoma 32 years after treatment of germ cell tumor confined to testis. Urology. 2006;67(4):846.
Plaza JA, Perez-Montiel D, Mayerson J, Morrison C, Suster S. Metastases to soft tissue: a review of 118 cases over a 30-year period. Cancer. 2008;112:193–203. doi:10.1002/cncr.23151.
Bilici A, Ustaalioglu BB, Seker M, Kayahan S. Soft tissue metastasis from immature teratoma of the testis: second case report and review of the literature. Clin Orthop Relat Res. 2010;468(9):2541–4.
Oosterhuis JW, Peeters SH, Smit VT, Stoop H, Looijenga LH, Elzevier HW, Osanto S. Patient with two secondary somatic-type malignancies in a late recurrence of a testicular non-seminoma: illustration of potential and flaw of the cancer stem cell therapy concept. Int J Dev Biol. 2013;57(2–4):153–7.
Zeh N, Wild PJ, Bode PK, Kristiansen G, Moch H, Sulser T, Hermanns T. Retroperitoneal teratoma with somatic malignant transformation: a papillary renal cell carcinoma in a testicular germ cell tumor metastasis following platinum-based chemotherapy. BMC Urol. 2013;13:9.
Fung C, Fossa SD, Milano MT, Oldenburg J, Travis LB. Solid tumors after chemotherapy or surgery for testicular nonseminoma: a population-based study. J Clin Oncol. 2013;31(30):3807–14.
Mesbahi O E, Terrier-Lacombe MJ, Rebischung C, Theodore C, Vanel D, Fizazi K. Chemotherapy in patients with teratoma with malignant transformation. Eur Urol. 2007;51(5):1306–11.
Vaughn DJ, Hwang W, Lal P, Rosen MA, Gallagher M, O’Dwyer PJ. Phase 2 trial of the cyclin-dependent kinase 4/6 inhibitor palbociclib in patients with retinoblastoma protein-expressing germ cell tumors. Cancer. 2015;121(9):1463–8.
Conflict of interests
A. E. Juarso, M. Kiehl, O. Pfennig, G. Wittenberg, and F. Weissinger declare that there are no actual or potential conflicts of interest in relation to this article.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Juarso, A., Kiehl, M., Pfennig, O. et al. A 59-year-old patient with somatic type malignancy as a relapse of testicular tumor after 28 years. memo 8, 194–197 (2015). https://doi.org/10.1007/s12254-015-0222-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12254-015-0222-8