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Gastrointestinal Mucositis: The Role of MMP-Tight Junction Interactions in Tissue Injury

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Pathology & Oncology Research

Abstract

Chemotherapy for cancer causes significant gut toxicity known as mucositis. The pathogenesis of mucositis is ill defined. Recent clinical research guidelines have highlighted epithelial junctional complexes as emerging targets within mucositis research. Given the robust biological evidence linking tight junctions and matrix metalloproteinases, key mediators of mucositis, tight junction proteins have received significant attention. Despite this, the link between tight junctions, matrix metalloproteinases and mucositis development is yet to be established. This critical review therefore aims to describe the role of matrix metalloproteinases in mucositis, and how matrix metalloproteinase-dependent tight junction disruption may contribute to the pathobiology of mucositis.

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Acknowledgments

Dr Noor Al-Dasooqi is a Clinical Centre of Research Excellence Post-Doctoral Research Fellow; Ms Hannah Wardill is the recipient of an Australian Post-Graduate Scholarship

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Authors and Affiliations

  1. School of Medicine, University of Adelaide, North Terrace, Adelaide, 5005, Australia

    Noor Al-Dasooqi

  2. School of Medical Sciences, University of Adelaide, Adelaide, Australia

    Hannah R. Wardill & Rachel J Gibson

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  1. Noor Al-Dasooqi
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  2. Hannah R. Wardill
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  3. Rachel J Gibson
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Correspondence to Noor Al-Dasooqi.

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Al-Dasooqi, N., Wardill, H.R. & Gibson, R.J. Gastrointestinal Mucositis: The Role of MMP-Tight Junction Interactions in Tissue Injury. Pathol. Oncol. Res. 20, 485–491 (2014). https://doi.org/10.1007/s12253-013-9733-y

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  • DOI: https://doi.org/10.1007/s12253-013-9733-y

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