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Oxidant/Antioxidant Status, Lipids and Hormonal Profile in Overweight Women with Breast Cancer

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Pathology & Oncology Research

Abstract

This study was carried out to determine the relationships between leptin concentrations, lipid alterations, oxidant/ antioxidant status, in vitro LDL oxidizability and LDL-fatty acid composition in overweight breast cancer patients. Glucose, insulin, leptin, lipids, LDL-cholesteryl ester fatty acids, markers of oxidant status (MDA, Hydroperoxides, carbonyl proteins, conjugated dienes) and markers of antioxidant status (vitamins A, C, E, erythrocyte activities of the enzymes superoxide dismutase, SOD, catalase, glutathione peroxidase,GPx, and glutathione reductase, GR and the serum total antioxidant status, ORAC) were investigated in breast cancer patients and in control women. Our findings showed that insulin, leptin, triglyceride, cholesterol and LDL-C concentrations were increased in patients compared to controls. ORAC and vitamin C and E values were lower while plasma hydroperoxide, carbonyl protein and conjugated diene levels, SOD and GPx activities were higher than in controls. Alterations in LDL-fatty acid composition were associated with their enhanced oxidative susceptibility. There were significant positive correlations between leptin concentrations and LDL-C, hydroperoxides, carbonyl proteins, SOD activity, baseline conjugated diene levels and oxidation rate, and significant negative correlations between leptin and ORAC, lag time and LDL-PUFA in patients. In conclusion, breast cancer is associated with lipid alterations and enhanced oxidative stress linked to high leptin levels in overweight.

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Acknowledgements

This research was supported by grants from the French Foreign office (International Research Extension Grants) and by a financial support from the Algerian Research investigation.

Competing interests

The author(s) declare that they have no competing interests.

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Authors and Affiliations

  1. Department of Molecular and Cellular Biology, Faculty of Sciences, University of Tlemcen, Tlemcen, Algeria

    Naima Badid, Fatima Zohra Baba Ahmed, Hafida Merzouk & Nassima Mokhtari

  2. School of nutrition, University of Moncton, Moncton, Canada

    Slimane Belbraouet

  3. Department of Technical Sciences, Faculty of Engineering, University of Tlemcen, Tlemcen, Algeria

    Sid Ahmed Merzouk

  4. Division of Obstetrics and Gynecology, Tlemcen Hospital, Tlemcen, Algeria

    Riad Benhabib

  5. Surgery Clinic AVICENE, Maghnia, Algeria

    Djalloul Hamzaoui

  6. INSERM UMR 866, ‘Lipids Nutrition Cancer’, University of Bourgogne, Faculty of Sciences, Dijon, France

    Michel Narce

  7. Laboratory of Physiology and Biochemistry of Nutrition, Department of Molecular and Cellular Biology, Faculty of Sciences, University ABOU-BEKR BELKAÏD, Tlemcen, 13000, Algeria

    Hafida Merzouk

Authors
  1. Naima Badid
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  2. Fatima Zohra Baba Ahmed
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  3. Hafida Merzouk
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  4. Slimane Belbraouet
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  5. Nassima Mokhtari
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  6. Sid Ahmed Merzouk
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  8. Djalloul Hamzaoui
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  9. Michel Narce
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Correspondence to Hafida Merzouk.

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Badid, N., Baba Ahmed, F.Z., Merzouk, H. et al. Oxidant/Antioxidant Status, Lipids and Hormonal Profile in Overweight Women with Breast Cancer. Pathol. Oncol. Res. 16, 159–167 (2010). https://doi.org/10.1007/s12253-009-9199-0

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  • DOI: https://doi.org/10.1007/s12253-009-9199-0

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