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Synthesis and characterization of poly(N-tert-butylacrylamide-co-acrylamide) hydrogel with enhanced responsive properties

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Abstract

To synthesize a series of novel temperature sensitive hydrogels, N-tert-butylacrylamide (NtBA) and acrylamide (AAm) were used as the comonomers and polymerized by free-radical crosslinking copolymerizarion. The poly(ethylene glycol) (PEG) with molecular weight of 400, 4000 and 6000 g·mol-1 was used as the porogen. The equilibrium swelling capacity, swelling/deswelling kinetics and diffusion parameters of obtained hydrogels were systematically evaluated. As revealed by SEM micrographs, the macroporous structure of hydrogels can be modulated by the crosslinking level, PEG molecular weight and dosage. FTIR analysis demonstrated that the porogen PEG was completely leached out of the gel matrix. Compared with the conventional hydrogels, the PEG-modified (PGel) hydrogels exhibited enhanced temperature sensitivity and superior kinetics during the swelling, deswelling and pulsatile swelling processes. Controlled release of salicylic acid also demonstrated the good usability of PGel hydrogel, which rendered it great potential for controlled drug delivery systems.

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Authors and Affiliations

  1. State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing, 210023, People’s Republic of China

    Qimeng Li

  2. Department of Hematology, Linyi People’s Hospital, Linyi, 276003, People’s Republic of China

    Yanying Chen

  3. School of Environmental Science and Engineering, Shandong University, Shandong, 250100, People’s Republic of China

    Yuzhu Jia & Canzhu Gao

  4. Shandong Taihe Water Treatment Co., Ltd., Xiwangzhuang Town, Shizhong District, Zaozhuang City, Shandong, 277100, People’s Republic of China

    Zhongfa Cheng

Authors
  1. Qimeng Li
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  2. Yanying Chen
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  3. Yuzhu Jia
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  4. Canzhu Gao
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  5. Zhongfa Cheng
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Corresponding author

Correspondence to Canzhu Gao.

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Li, Q., Chen, Y., Jia, Y. et al. Synthesis and characterization of poly(N-tert-butylacrylamide-co-acrylamide) hydrogel with enhanced responsive properties. Fibers Polym 18, 825–834 (2017). https://doi.org/10.1007/s12221-017-1085-x

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  • DOI: https://doi.org/10.1007/s12221-017-1085-x

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