Abstract
Polyurethane (PU) foam was combined with protein drug-loaded pH-sensitive alginate-bentonite hydrogel for wound dressings. Alginate is a linear copolymer composed of 1–4-linked β-D-mannuronic acid (M) and its c-5-epimer α-Lguluronic acid (G). The amount of (M) and (G) and their sequential distribution are varied depending on the alginate source. Soluble sodium alginate can become a hydrogel when cross-linked with divalent cations and has widespread applications in the food, drink, pharmaceutical and bioengineering industries. Recently, it has been also proposed as a biomaterial for drug delivery systems. Bentonites are the natural inorganic polymers consisting of a large proportion of expandable clay minerals with a three-layer structure such as montmorillonite, beidellite, nontronite, etc. They are important adjutants and supports for medical products, and they have many useful physicochemical, mechanical, and biological properties such as absence of toxicity, indifference to other raw materials, sorption, swelling, and complex formation properties. Alginate-bentonite hydrogels were prepared at concentration ratios of 10/0, 7/3, 5/5, 3/7. PU foams were prepared using hydrophilic polyols. We investigated the controlled release of a protein drug from PU foam combined with alginate-bentonite hydrogel at different pH values of 4.2, 5.2, 7.2, 8.2. The mechanical properties and cytotoxicity tests of this foam were also studied.
Similar content being viewed by others
References
J. Y. Kown and H. D. Kim, Fiber. Polym., 7, 12 (2006).
W. J. Seo, Y. T. Sung, S. J. Han, Y. H. Kim, O. H. Ryu, H. S. Lee, and W. N. Kim, J. Appl. Polym. Sci., 101, 2879 (2006).
Y. Liu, Y. Ni, and S. Zheng, Macromol. Chem. Phys., 207, 1842 (2006).
J. Paciorek-Sadowska and B. Czupryński, J. Appl. Polym. Sci., 102, 5918 (2006).
I. Yilgör and E. Yilgör, Polymer, 40, 5575 (1999).
T. Thomson, “Design and Applications of Hydrophilic Polyurethanes”, pp.11–42, Technomic Publishign Company Inc., Lancaster, Pennsylvania, 2000.
W. E. Hennink and C. F. van Nostrum, Adv. Drug Deliv. Rev., 54, 13 (2002).
A. S. Hoffman, Adv. Drug Deliv. Rev., 43, 3 (2002).
P. V. Finotelli, M. A. Morales, M. H. R. Leao, E. M. B. Saitovitch, and A. M. Rossi, Mat. Sci. Eng. C-BIO. S., 24, 625 (2004).
P. Aslani and R. A. Kennedy, J. Control. Release, 42, 75 (1996).
C. Chretien and J. C. Chaumeil, Int. J. Pharm., 304, 18 (2005).
A. C. Hodsdon, J. R. Mitchell, M. C. Davies, and C. D. Melia, J. Control. Rel., 33, 143 (1995).
Z. Dong, Q. Wang, and Y. Du, J. Membrane. Sci., 280, 37 (2006).
D. Tada, T. Tanabe, A. Tachibana, and K. Yamauchi, Mat. Sci. Eng. C-BIO. S., 27, 870 (2007).
F. J. G. Herrera, E. G. Pradas, and M. F. Perez, J. Agr. Food. Chem., 54, 10053 (2006).
B. A. Mostafa and F. F. Assaad, J. Appl. Polym. Sci., 104, 3886 (2007).
L. W. Chan, H. Y. Lee, and P. W. S. Heng, Int. J. Pharm., 242, 259 (2002).
L. W. Chan, H. Y. Lee, and P. W. S. Heng, Carbohyd. Polym., 63, 176 (2006).
S. C. Chen, Y. C. Wu, F. L. Mi, Y. H. Lin, L. C. Yu, and H. W. Sung, J. Control. Rel., 96, 285 (2004).
P. Eiselt, J. Yeh, R. K. Latvala, L. D. Shea, and D. J. Mooney, Biomaterials, 21, 1921 (2000).
M. F. Perez, E. G. Pradas, M. V. Sanchez, and F. F. Cespedes, Chemosphere, 41, 1495 (2000).
C. J. Gray and J. Dowsett, Biotech. Bioeng., 31, 607 (1988).
F. Iemma, U. G. Spizzirri, F. Puoci, R. Muzzalupo, S. Trombino, R. Cassano, S. Leta, and N. Picci, Int. J. Pharm., 312, 151 (2006).
C. K. Kim and E. J. Kee, Int. J. Pharm., 79, 11 (1992).
S. Sakai, T. Ono, H. Ijima, and K. Kawakami, Biochem. Eng. J., 22, 19 (2004).
S. T. Oh, O. J. Kwon, B. C. Chun, J. W. Cho, and J. S. Park, Fiber. Polym., 10, 21 (2009).
Y. M. Tien, P. L. Wu, W. H. Huang, M. F. Kuo, and C. A. Chu, Powder. Technol., 173, 140 (2007).
P. Lienmann, G. Loew, S. Burt, J. Lawless, and R. D. Macelroy, Inorg. Chem., 21, 1586 (1982).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Oh, ST., Kim, WR., Kim, SH. et al. The preparation of polyurethane foam combined with pH-sensitive alginate/bentonite hydrogel for wound dressings. Fibers Polym 12, 159–165 (2011). https://doi.org/10.1007/s12221-011-0159-4
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12221-011-0159-4