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Prevention of chemotherapy-induced alopecia in rodent models

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Cell Stress and Chaperones Aims and scope

Abstract

Alopecia (hair loss) is experienced by thousands of cancer patients every year. Substantial-to-severe alopecia is induced by anthracyclines (e.g., adriamycin), taxanes (e.g., taxol), alkylating compounds (e.g., cyclophosphamide), and the topisomerase inhibitor etoposide, agents that are widely used in the treatment of leukemias and breast, lung, ovarian, and bladder cancers. Currently, no treatment appears to be generally effective in reliably preventing this secondary effect of chemotherapy. We observed in experiments using different rodent models that localized administration of heat or subcutaneous/intradermal injection of geldanamycin or 17-(allylamino)-17-demethoxygeldanamycin induced a stress protein response in hair follicles and effectively prevented alopecia from adriamycin, cyclophosphamide, taxol, and etoposide. Model tumor therapy experiments support the presumption that such localized hair-saving treatment does not negatively affect chemotherapy efficacy.

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Acknowledgments

We thank M. Fenna, J. He, J. Xie, and S.L. Hsia for their help with certain experiments, and Walter Scott and David Barber for the critical review of the manuscript. This study was supported in part by the Rockefeller Brothers Fund (02-237), NCI grant R01 CA093489, and HSF Pharmaceuticals S.A.

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Authors and Affiliations

  1. Department of Medicine, University of Miami, Miami, FL, USA

    Joaquin J. Jimenez

  2. Center for Environmental and Human Toxicology, Department of Physiological Sciences, University of Florida, Gainesville, FL, USA

    Stephen M. Roberts & John W. Munson

  3. Department of Biochemistry and Molecular Biology, University of Miami, Miami, FL, USA

    Jessica Mejia, Lucia M. Mauro & Richard Voellmy

  4. Department of Dermatology and Cutaneous Surgery, University of Miami, Miami, FL, USA

    George W. Elgart & Elizabeth Alvarez Connelly

  5. Department of Pediatrics, University of Miami, Miami, FL, USA

    Elizabeth Alvarez Connelly

  6. School of Pharmaceutical Science, Zhongshan Medical College, Sun Yat-sen University, Guangzhou, People’s Republic of China

    Qingbin Chen

  7. Guangzhou Institute of Biomedicine and Health, Guangzhou, People’s Republic of China

    Jiangying Zou

  8. Department of Pathology, Hialeah Hospital, Hialeah, FL, USA

    Carlos Goldenberg

  9. HSF Pharmaceuticals S.A., Av. des Cerisiers 39B, 1009, Pully, Switzerland

    Richard Voellmy

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  1. Joaquin J. Jimenez
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  2. Stephen M. Roberts
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  3. Jessica Mejia
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  4. Lucia M. Mauro
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  7. Elizabeth Alvarez Connelly
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  8. Qingbin Chen
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  9. Jiangying Zou
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  10. Carlos Goldenberg
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  11. Richard Voellmy
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Corresponding author

Correspondence to Richard Voellmy.

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Jimenez, J.J., Roberts, S.M., Mejia, J. et al. Prevention of chemotherapy-induced alopecia in rodent models. Cell Stress and Chaperones 13, 31–38 (2008). https://doi.org/10.1007/s12192-007-0005-1

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  • DOI: https://doi.org/10.1007/s12192-007-0005-1

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