Skip to main content
SpringerLink
Log in

Comprehensive software suite for the operation, maintenance, and evaluation of an ion mobility spectrometer

  • Software Applications
  • Published:
International Journal for Ion Mobility Spectrometry

Abstract

Scientific applications of Ion Mobility Spectrometry require the ability to easily compare data between different laboratories. Reduced mobility values attempt to provide this functionality, but no standard exists for the collection and manipulation of the raw data obtained during an IMS experiment. We have created a comprehensive software suite based on the LabVIEW programming language that can be used to collect and interpret IMS data. The software may be used to collect data from a stand-alone IMS cell, a voltage sweep IMS cell, or a coupled chromatography-IMS system, and this framework may be adapted to incorporate mass spectral data analysis as well. This software is provided under an open source license for the benefit of the IMS community.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Baumbach JI, Davies AN et al (2001) JCAMP-DX—A standard format for the exchange of ion mobility spectrometry data (IUPAC Recommendations 2001). Pure Appl Chem 73(11):1765–1782

    Article  CAS  Google Scholar 

  2. Baumbach JI, Lampen P et al (1998) IUPAC/JCAMP-DX: an international standard for the exchange of ion mobility spectrometry data. Int J Ion Mobil Spec 1(1):64–67

    CAS  Google Scholar 

  3. Bodeker B, Vautz W et al (2008a) Peak finding and referencing in MCC/IMS-data. Int J Ion Mobil Spec 11:83–87

    Article  Google Scholar 

  4. Bodeker B, Vautz W et al (2008b) Visualisation of MCC/IMS-data. Int J Ion Mobil Spec 11:77–81

    Article  Google Scholar 

  5. Bramwell CJ, Creaser CS et al (2002) Atmospheric pressure matrix-assisted laser desorption/ionization combined with ion mobility spectrometry. Int J Ion Mobil Spec 5(3):87–90

    CAS  Google Scholar 

  6. Cao L, Harrington PdB et al (2004) Two-dimensional nonlinear wavelet compression of ion mobility spectra of chemical warfare agent simulants. Anal Chem 76:2859–2868

    Article  CAS  Google Scholar 

  7. Clemmer DE, Hudgins RR et al (1995) Naked protein conformations: cytochrome c in the gas phase. J Am Chem Soc 117:10141–10142

    Article  CAS  Google Scholar 

  8. Daum KA, Atkinson DA et al (2002) The role of oxygen in the formation of TNT product ions in ion mobility spectrometry. Int J Ion Mobil Spec 214:257–267

    CAS  Google Scholar 

  9. Davies AN, Baumbach JI et al (2001) Finalisation of a IUPAC/JCAMP-DX data transfer standard for ion mobility spectrometry data. Int J Ion Mobil Spec 4(1):84–108

    CAS  Google Scholar 

  10. Davies AN, Lampen P et al (2002) Reporting ion mobility spectrometry data and the IUPAC/JCAMP-DX international data standard. Int J Ion Mobil Spec 5(1):47–50

    CAS  Google Scholar 

  11. Davis EJ, Williams MD et al (2011) Voltage sweep ion mobility spectrometry. Anal Chem 83(4):1260–1267

    Article  CAS  Google Scholar 

  12. Dwivedi P, Bendiak B et al (2007) Rapid resolution of carbohydrate isomers by electrospray ionization ambient pressure ion mobility spectrometry-time-of-flight mass spectrometry (ESI-APIMS-TOFMS). J Am Soc Mass Spectrom 18:1163–1175

    Article  CAS  Google Scholar 

  13. Dwivedi P, Wu P et al (2008) Metabolic profiling by ion mobility mass spectrometry (IMMS). Metabolomics 4:63–80

    Article  CAS  Google Scholar 

  14. Eiceman GA, Karpas Z (1994) Ion mobility spectrometry. CRC Press, Inc, Boca Raton

    Google Scholar 

  15. Eiceman GA, Nazarov EG et al (2003) Chemical standards in ion mobility spectrometry. Anal Chim Acta 493:185–194

    Article  CAS  Google Scholar 

  16. Gillig KJ, Ruotolo B et al (2000) Coupling high-pressure MALDI with ion mobility/orthogonal time-of-flight mass spectrometry. Anal Chem 72:3965–3971

    Article  CAS  Google Scholar 

  17. Hariharan CB, Baumbach JI et al (2010) Linearized equations for the reduced ion mobilities of polar aliphatic organic compounds. Anal Chem 82(1):427–431

    Article  CAS  Google Scholar 

  18. Kanu AB, Dwivedi P et al (2008) Ion mobility-mass spectrometry. J Mass Spectrom 46:1–22

    Article  Google Scholar 

  19. Leavell MD, Gaucher SP et al (2002) Conformational studies of Zn-Ligand-Hexose diastereomers using ion mobility measrements and density functional theory calculations. J Am Soc Mass Spectrom 13(3):284–293

    Article  CAS  Google Scholar 

  20. Stone E, Gillig KJ et al (2001) Surface-induced dissociation on a MALDI-ion mobility-orthogonal time-of-flight mass spectrometer: sequencing peptides from an “In-Solution” protein digest. Anal Chem 73:2233–2238

    Article  CAS  Google Scholar 

  21. Vautz W, Bodeker B et al (2008) Recommendation of a standard format for data sets from GC/IMS with sensor-controlled sampling. Int J Ion Mobil Spec 11:71–76

    Article  CAS  Google Scholar 

  22. Zhou L, Collins DC et al (2007) Mechanical ion gate for electrospray-ionization ion-mobility spectrometry. Anal Bioanal Chem 388:189–194

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, Washington State University, Pullman, WA, 99164, USA

    Eric James Davis, William F. Siems & Herbert H. Hill Jr.

  2. National Security Directorate, Pacific Northwest National Laboratory, Richland, WA, USA

    Brian H. Clowers

Authors
  1. Eric James Davis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Brian H. Clowers
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. William F. Siems
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Herbert H. Hill Jr.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Eric James Davis.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Davis, E.J., Clowers, B.H., Siems, W.F. et al. Comprehensive software suite for the operation, maintenance, and evaluation of an ion mobility spectrometer. Int. J. Ion Mobil. Spec. 14, 117–124 (2011). https://doi.org/10.1007/s12127-011-0068-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12127-011-0068-7

Keywords

Search

Navigation