Kane CJ, Mallin K, Ritchey J, Cooperberg MR, Carroll PR. Renal cell cancer stage migration: analysis of the National Cancer Data Base. Cancer. 2008;113(1):78–83.
PubMed
Google Scholar
Galceran J, Ameijide A, Carulla M, Mateos A, Quirós JR, Rojas D, Alemán A, Torrella A, Chico M, Vicente M, Díaz JM, Larrañaga N, Marcos-Gragera R, Sánchez MJ, Perucha J, Franch P, Navarro C, Ardanaz E, Bigorra J, Rodrigo P, Bonet RP. Cancer incidence in Spain, 2015. Clin Transl Oncol. 2017;19(7):799–825.
CAS
PubMed
Google Scholar
Chow W-H, Dong LM, Devesa SS. Epidemiology and risk factors for kidney cancer. Nat Rev Urol. 2010;7(5):245–57.
PubMed
PubMed Central
Google Scholar
Dykewicz CA, Centers for Disease Control and Prevention (U.S.), Infectious Diseases Society of America, American Society of Blood and Marrow Transplantation. Summary of the Guidelines for Preventing Opportunistic Infections among Hematopoietic Stem Cell Transplant Recipients. Clin Infect Dis Off Publ Infect Dis Soc Am. 2001;33(2):139–44.
CAS
PubMed
PubMed Central
Google Scholar
Jamis-Dow CA, Choyke PL, Jennings SB, Linehan WM, Thakore KN, Walther MM. Small (< or = 3-cm) renal masses: detection with CT versus US and pathologic correlation. Radiology. 1996;198(3):785–8.
CAS
PubMed
Google Scholar
Mazzei FG, Mazzei MA, Cioffi Squitieri N, Pozzessere C, Righi L, Cirigliano A, et al. CT perfusion in the characterisation of renal lesions: an added value to multiphasic CT. Biomed Res Int. 2014;2014:135013.
PubMed
PubMed Central
Google Scholar
van Oostenbrugge TJ, Fütterer JJ, Mulders PFA. Diagnostic imaging for solid renal tumors: a pictorial review. Kidney Cancer. 2018;2(2):79–93.
PubMed
PubMed Central
Google Scholar
Escudier B, Porta C, Schmidinger M, Rioux-Leclercq N, Bex A, Khoo V, et al. Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†. Ann Oncol Off J Eur Soc Med Oncol. 2019;30(5):706–20.
CAS
Google Scholar
Lindenberg L, Mena E, Choyke PL, Bouchelouche K. PET imaging in renal cancer. Curr Opin Oncol. 2019;31(3):216–21.
PubMed
Google Scholar
Rini B, McKiernan JM, Chang SS. Kidney AJCC cancer staging manual. 8th ed. New York: Springer; 2017. p. 739.
Google Scholar
Cairns P. Renal cell carcinoma. Srivastava S, Grizzle WE, editors. Cancer Biomark. 2011 Oct 26;9(1–6):461–73.
Patard J-J, Leray E, Rioux-Leclercq N, Cindolo L, Ficarra V, Zisman A, et al. Prognostic value of histologic subtypes in renal cell carcinoma: a multicenter experience. J Clin Oncol Off J Am Soc Clin Oncol. 2005;23(12):2763–71.
Google Scholar
Creighton CJ, Morgan M, Gunaratne PH, Wheeler DA, Gibbs RA, Gordon Robertson A, et al. Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature. 2013;499(7456):43–9.
CAS
Google Scholar
Cancer Genome Atlas Research Network, Linehan WM, Spellman PT, Ricketts CJ, Creighton CJ, Fei SS, et al. Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma. N Engl J Med. 2016 14;374(2):135–45.
Chen F, Zhang Y, Şenbabaoğlu Y, Ciriello G, Yang L, Reznik E, et al. Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma. Cell Rep [Internet]. 2016 Mar 3 [cited 2016 Mar 7];0(0). http://www.cell.com/article/S2211124716301279/abstract
Davis CF, Ricketts CJ, Wang M, Yang L, Cherniack AD, Shen H, et al. The somatic genomic landscape of chromophobe renal cell carcinoma. Cancer Cell. 2014;26(3):319–30.
CAS
PubMed
PubMed Central
Google Scholar
Beuselinck B, Job S, Becht E, Karadimou A, Verkarre V, Couchy G, et al. Molecular subtypes of clear cell renal carcinoma are associated with suninitib reponse in the metastatic settings. Clin Cancer Res Off J Am Assoc Cancer Res. 2015;21(6):1329–39.
CAS
Google Scholar
Gerlinger M, Horswell S, Larkin J, Rowan AJ, Salm MP, Varela I, et al. Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing. Nat Genet. 2014;46(3):225–33.
CAS
PubMed
PubMed Central
Google Scholar
Zisman A, Pantuck AJ, Wieder J, Chao DH, Dorey F, Said JW, et al. Risk group assessment and clinical outcome algorithm to predict the natural history of patients with surgically resected renal cell carcinoma. J Clin Oncol Off J Am Soc Clin Oncol. 2002;20(23):4559–66.
Google Scholar
MacLennan S, Imamura M, Lapitan MC, Omar MI, Lam TBL, Hilvano-Cabungcal AM, et al. Systematic review of oncological outcomes following surgical management of localised renal cancer. Eur Urol. 2012;61(5):972–93.
PubMed
Google Scholar
Pierorazio PM, Johnson MH, Patel HD, Sozio SM, Sharma R, Iyoha E, et al. Management of renal masses and localized renal cancer: systematic review and meta-analysis. J Urol. 2016;196(4):989–99.
PubMed
PubMed Central
Google Scholar
Dash A, Vickers AJ, Schachter LR, Bach AM, Snyder ME, Russo P. Comparison of outcomes in elective partial vs radical nephrectomy for clear cell renal cell carcinoma of 4–7 cm. BJU Int. 2006;97(5):939–45.
PubMed
Google Scholar
Mir MC, Capitanio U, Bertolo R, Ouzaid I, Salagierski M, Kriegmair M, et al. Role of active surveillance for localized small renal masses. Eur Urol Oncol. 2018;1(3):177–87.
PubMed
Google Scholar
European Association of Urology EAU Guidelines. Edn. presented at the EAU Annual Congress Copenhagen 2018. ISBN 978-94-92671-01-1. 2018 [Internet]. https://uroweb.org/guideline/renal-cell-carcinoma/
Ravaud A, Motzer RJ, Pandha HS, George DJ, Pantuck AJ, Patel A, et al. Adjuvant Sunitinib in high-risk renal-cell carcinoma after nephrectomy. N Engl J Med. 2016 08;375(23):2246–54.
CAS
PubMed
Google Scholar
Haas NB, Manola J, Uzzo RG, Flaherty KT, Wood CG, Kane C, et al. Adjuvant sunitinib or sorafenib for high-risk, non-metastatic renal-cell carcinoma (ECOG-ACRIN E2805): a double-blind, placebo-controlled, randomised, phase 3 trial. Lancet. 2016;387(10032):2008–16.
CAS
PubMed
PubMed Central
Google Scholar
Haas NB, Manola J, Dutcher JP, Flaherty KT, Uzzo RG, Atkins MB, et al. Adjuvant treatment for high-risk clear cell renal cancer: updated results of a high-risk subset of the ASSURE randomized trial. JAMA Oncol. 2017;3(9):1249–52.
PubMed
PubMed Central
Google Scholar
Motzer RJ, Haas NB, Donskov F, Gross-Goupil M, Varlamov S, Kopyltsov E, et al. Randomized phase III trial of adjuvant pazopanib versus placebo after nephrectomy in patients with localized or locally advanced renal cell carcinoma. J Clin Oncol Off J Am Soc Clin Oncol. 2017;35(35):3916–23.
CAS
Google Scholar
Gross-Goupil M, Kwon TG, Eto M, Ye D, Miyake H, Seo SI, et al. Axitinib versus placebo as an adjuvant treatment of renal cell carcinoma: results from the phase III, randomized ATLAS trial. Ann Oncol. 2018;29(12):2371–8.
CAS
PubMed
PubMed Central
Google Scholar
Eisen T, Frangou E, Smith B, Ritchie A, Kaplan RS, Oza B, et al. Primary efficacy analysis results from the SORCE trial (RE05): Adjuvant sorafenib for renal cell carcinoma at intermediate or high risk of relapse: An international, randomised double-blind phase III trial led by the MRC CTU at UCL. Ann Oncol. 2019 Oct;30(Suppl 5):LBA-56.
Gul A, Rini BI. Adjuvant therapy in renal cell carcinoma. Cancer. 2019;125(17):2935–44.
PubMed
Google Scholar
Motzer RJ, Mazumdar M, Bacik J, Berg W, Amsterdam A, Ferrara J. Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol Off J Am Soc Clin Oncol. 1999;17(8):2530–40.
CAS
Google Scholar
Motzer RJ, Bacik J, Murphy BA, Russo P, Mazumdar M. Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol Off J Am Soc Clin Oncol. 2002;20(1):289–96.
CAS
Google Scholar
Heng DYC, Xie W, Regan MM, Warren MA, Golshayan AR, Sahi C, et al. Prognostic factors for overall survival in patients with metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted agents: results from a large, multicenter study. J Clin Oncol Off J Am Soc Clin Oncol. 2009;27(34):5794–9.
CAS
Google Scholar
Pérez-Valderrama B, Arranz Arija JA, Rodríguez Sánchez A, Pinto Marín A, Borrega García P, Castellano Gaunas DE, et al. Validation of the International Metastatic Renal-Cell Carcinoma Database Consortium (IMDC) prognostic model for first-line pazopanib in metastatic renal carcinoma: the Spanish Oncologic Genitourinary Group (SOGUG) SPAZO study. Ann Oncol Off J Eur Soc Med Oncol. 2016;27(4):706–11.
Google Scholar
Heng DYC, Xie W, Regan MM, Harshman LC, Bjarnason GA, Vaishampayan UN, et al. External validation and comparison with other models of the International Metastatic Renal-Cell Carcinoma Database Consortium prognostic model: a population-based study. Lancet Oncol. 2013;14(2):141–8.
PubMed
PubMed Central
Google Scholar
Ko JJ, Xie W, Kroeger N, Lee J-L, Rini BI, Knox JJ, et al. The International Metastatic Renal Cell Carcinoma Database Consortium model as a prognostic tool in patients with metastatic renal cell carcinoma previously treated with first-line targeted therapy: a population-based study. Lancet Oncol. 2015;16(3):293–300.
PubMed
Google Scholar
Kroeger N, Xie W, Lee J-L, Bjarnason GA, Knox JJ, Mackenzie MJ, et al. Metastatic non-clear cell renal cell carcinoma treated with targeted therapy agents: characterization of survival outcome and application of the International mRCC Database Consortium criteria. Cancer. 2013;119(16):2999–3006.
CAS
PubMed
PubMed Central
Google Scholar
Bex A, Mulders P, Jewett M, Wagstaff J, van Thienen JV, Blank CU, van Velthoven R, del Pilar Laguna M, Wood L,van Melick HHE, Aarts MJ, Lattouf JB, Powles T, de Jong IJ, Rottey S, Tombal B, Marreaud S, Collette S, Collette L, Haanen J (2019) Comparison of immediate vs deferred cytoreductive nephrectomy in patients with synchronous metastatic renal cell Carcinoma receiving Sunitinib. JAMA Oncol 5(2):164
PubMed
Google Scholar
Méjean A, Ravaud A, Thezenas S, Colas S, Beauval J-B, Bensalah K, Geoffrois L, Thiery-Vuillemin A, Cormier L, Lang H, Guy L, Gravis G, Rolland F, Linassier C, Lechevallier E, Beisland C, Aitchison M, Oudard S, Patard J-J, Theodore C, Chevreau C, Laguerre B, Hubert J, Gross-Goupil M, Bernhard J-C, Albiges L, Timsit M-O, Lebret T, Escudier B. Sunitinib alone or after nephrectomy in metastatic renal-cell Carcinoma. N Engl J Med. 2018;379(5):417–27
PubMed
Google Scholar
Zaid HB, Parker WP, Safdar NS, Gershman B, Erwin PJ, Murad MH, Boorjian SA, Costello BA, Thompson RH, Leibovich BC. Outcomes following complete surgical metastasectomy for patients with metastatic renal cell Carcinoma: a systematic review and meta-analysis. J Urol. 2017;197(1):44–9.
PubMed
Google Scholar
Rini BI, Dorff TB, Elson P, Rodriguez CS, Shepard D, Wood L, et al. Active surveillance in metastatic renal-cell carcinoma: a prospective, phase 2 trial. Lancet Oncol. 2016;17(9):1317–24.
PubMed
Google Scholar
Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Rixe O, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med. 2007;356(2):115–24.
CAS
PubMed
Google Scholar
Sternberg CN, Davis ID, Mardiak J, Szczylik C, Lee E, Wagstaff J, et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J Clin Oncol Off J Am Soc Clin Oncol. 2010;28(6):1061–8.
CAS
Google Scholar
Escudier B, Pluzanska A, Koralewski P, Ravaud A, Bracarda S, Szczylik C, et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet Lond Engl. 2007;370(9605):2103–11.
Google Scholar
Rini BI, Halabi S, Rosenberg JE, Stadler WM, Vaena DA, Ou S-S, et al. Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206. J Clin Oncol Off J Am Soc Clin Oncol. 2008;26(33):5422–8.
CAS
Google Scholar
Motzer RJ, Nosov D, Eisen T, Bondarenko I, Lesovoy V, Lipatov O, et al. Tivozanib versus sorafenib as initial targeted therapy for patients with metastatic renal cell carcinoma: results from a phase III trial. J Clin Oncol Off J Am Soc Clin Oncol. 2013;31(30):3791–9.
CAS
Google Scholar
Motzer RJ, Hutson TE, Cella D, Reeves J, Hawkins R, Guo J, et al. Pazopanib versus sunitinib in metastatic renal-cell carcinoma. N Engl J Med. 2013;369(8):722–31.
CAS
PubMed
Google Scholar
Choueiri TK, Halabi S, Sanford BL, Hahn O, Michaelson MD, Walsh MK, et al. Cabozantinib Versus Sunitinib As Initial Targeted Therapy for Patients With Metastatic Renal Cell Carcinoma of Poor or Intermediate Risk: The Alliance A031203 CABOSUN Trial. J Clin Oncol Off J Am Soc Clin Oncol. 2017 20;35(6):591–7.
Hudes G, Carducci M, Tomczak P, Dutcher J, Figlin R, Kapoor A, et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med. 2007;356(22):2271–81.
CAS
PubMed
Google Scholar
Motzer RJ, Tannir NM, McDermott DF, Arén Frontera O, Melichar B, Choueiri TK, et al. Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma. N Engl J Med. 2018;378(14):1277–90.
CAS
PubMed
PubMed Central
Google Scholar
Rini BI, Plimack ER, Stus V, Gafanov R, Hawkins R, Nosov D, et al. Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma. N Engl J Med. 2019 21;380(12):1116–27.
CAS
PubMed
Google Scholar
Motzer RJ, Penkov K, Haanen J, Rini B, Albiges L, Campbell MT, et al. Avelumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma. N Engl J Med. 2019 21;380(12):1103–15.
CAS
PubMed
Google Scholar
McDermott DF, Regan MM, Clark JI, Flaherty LE, Weiss GR, Logan TF, et al. Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma. J Clin Oncol Off J Am Soc Clin Oncol. 2005;23(1):133–41.
CAS
Google Scholar
Rini BI, Escudier B, Tomczak P, Kaprin A, Szczylik C, Hutson TE, et al. Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial. Lancet Lond Engl. 2011;378(9807):1931–9.
CAS
Google Scholar
Motzer RJ, Escudier B, Oudard S, Hutson TE, Porta C, Bracarda S, et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet Lond Engl. 2008;372(9637):449–56.
CAS
Google Scholar
Motzer RJ, Escudier B, McDermott DF, George S, Hammers HJ, Srinivas S, et al. Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma. N Engl J Med. 2015;373(19):1803–13.
CAS
PubMed
PubMed Central
Google Scholar
Choueiri TK, Escudier B, Powles T, Mainwaring PN, Rini BI, Donskov F, et al. Cabozantinib versus Everolimus in Advanced Renal-Cell Carcinoma. N Engl J Med. 2015;373(19):1814–23.
CAS
PubMed
PubMed Central
Google Scholar
Rini BI, Pal SK, Escudier B, Atkins MB, Hutson TE, Porta C, et al. TIVO-3: A phase III, randomized, controlled, multicenter, open-label study to compare tivozanib to sorafenib in subjects with refractory advanced renal cell carcinoma (RCC). J Clin Oncol. 2019 Mar;37(7_suppl):541–41.
Google Scholar
Motzer RJ, Hutson TE, Glen H, Michaelson MD, Molina A, Eisen T, et al. Lenvatinib, everolimus, and the combination in patients with metastatic renal cell carcinoma: a randomised, phase 2, open-label, multicentre trial. Lancet Oncol. 2015;16(15):1473–82.
CAS
PubMed
Google Scholar
Staehler M, Motzer RJ, George DJ, Pandha HS, Donskov F, Escudier B, et al. Adjuvant sunitinib in patients with high-risk renal cell carcinoma: safety, therapy management, and patient-reported outcomes in the S-TRAC trial. Ann Oncol Off J Eur Soc Med Oncol. 2018 01;29(10):2098–104.
CAS
PubMed
PubMed Central
Google Scholar
Heng DYC, Wells JC, Rini BI, Beuselinck B, Lee J-L, Knox JJ, et al. Cytoreductive nephrectomy in patients with synchronous metastases from renal cell carcinoma: results from the International Metastatic Renal Cell Carcinoma Database Consortium. Eur Urol. 2014;66(4):704–10.
PubMed
Google Scholar
Vera-Badillo FE, Templeton AJ, Duran I, Ocana A, de Gouveia P, Aneja P, et al. systemic therapy for non–clear cell renal cell carcinomas: a systematic review and meta-analysis. Eur Urol. 2015;67(4):740–9.
PubMed
Google Scholar
Jung KS, Lee SJ, Park SH, Lee J-L, Lee S-H, Lim JY, et al. Pazopanib for the treatment of non-clear cell renal cell carcinoma: a single-arm, open-label, multicenter, Phase II Study. Cancer Res Treat Off J Korean Cancer Assoc. 2018;50(2):488–94.
CAS
Google Scholar
Buti S, Bersanelli M, Maines F, Facchini G, Gelsomino F, Zustovich F, et al. First-line PAzopanib in NOn-clear-cell Renal cArcinoMA: the Italian Retrospective Multicenter PANORAMA study. Clin Genitourin Cancer. 2017;15(4):e609–14.
PubMed
Google Scholar
Martínez Chanzá N, Xie W, Asim Bilen M, Dzimitrowicz H, Burkart J, Geynisman DM, et al. Cabozantinib in advanced non-clear-cell renal cell carcinoma: a multicentre, retrospective, cohort study. Lancet Oncol. 2019;20(4):581–90.
PubMed
Google Scholar
Campbell MT, Bilen MA, Shah AY, Lemke E, Jonasch E, Venkatesan AM, et al. Cabozantinib for the treatment of patients with metastatic non-clear cell renal cell carcinoma: a retrospective analysis. Eur J Cancer Oxf Engl. 1990;2018(104):188–94.
Google Scholar
Prisciandaro M, Ratta R, Massari F, Fornarini G, Caponnetto S, Iacovelli R, et al. Safety and efficacy of cabozantinib for metastatic nonclear renal cell carcinoma: real-world data from an italian managed access program. Am J Clin Oncol. 2019;42(1):42–5.
CAS
PubMed
Google Scholar
Haas NB, Lin X, Manola J, Pins M, Liu G, McDermott D, et al. A phase II trial of doxorubicin and gemcitabine in renal cell carcinoma with sarcomatoid features: eCOG 8802. Med Oncol. 2012;29(2):761–7.
CAS
PubMed
Google Scholar
Escudier B, Droz JB, Rolland F, Terrier-Lacombe MJ, Gravis G, Beuzeboc P, Chauvet B, Chevreau C, Eymard JC, Lesimple T, Merrouche Y, Oudard S, Priou F, Guillemare C, Gourgou S, Culine S. Doxorubicin and ifosfamide in patients with metastatic sarcomatoid renal cell Carcinoma: a phase II study of the genitourinary group of the French Federation of Cancer Centers. J Urol. 2002;168(3):959–61.
CAS
PubMed
Google Scholar
Koshkin VS, Barata PC, Zhang T, George DJ, Atkins MB, Kelly WJ, et al. Clinical activity of nivolumab in patients with non-clear cell renal cell carcinoma. J Immunother Cancer. 2018 29;6(1):9.
Verzoni E, Cartenì G, Cortesi E, Giannarelli D, De Giglio A, Sabbatini R, et al. Real-world efficacy and safety of nivolumab in previously-treated metastatic renal cell carcinoma, and association between immune-related adverse events and survival: the Italian expanded access program. J Immunother Cancer. 2019;7(1):99.
PubMed
PubMed Central
Google Scholar
Powles T, Larkin JMG, Patel P, Pérez-Valderrama B, Rodriguez-Vida A, Glen H, et al. A phase II study investigating the safety and efficacy of savolitinib and durvalumab in metastatic papillary renal cancer (CALYPSO). J Clin Oncol. 2019 Mar;37(7_suppl):545–545.
Google Scholar
Lee J-L, Ziobro M, Gafanov R, Matveev VB, Suarez C, Donskov F, et al. KEYNOTE-427 cohort B: First-line pembrolizumab (pembro) monotherapy for advanced non‒clear cell renal cell carcinoma (NCC-RCC). J Clin Oncol. 2019 May 20;37(15 suppl):4569–69.
Google Scholar
Fernández-Pello S, Hofmann F, Tahbaz R, Marconi L, Lam TB, Albiges L, et al. A systematic review and meta-analysis comparing the effectiveness and adverse effects of different systemic treatments for non-clear cell renal cell carcinoma. Eur Urol. 2017;71(3):426–36.
PubMed
Google Scholar