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The utilization of saliva as an early diagnostic tool for oral cancer: microRNA as a biomarker

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Abstract

Recently, dentistry presents a preventive philosophy, seeking early diagnoses and minimally traumatic treatments for patients. Cancer is known for its aggressive nature, where its signals and symptoms may only appear in advanced stages of the disease, therefore, reducing the possibility of using atraumatic treatment options and patient survival. Saliva has in its composition substances which can be used as biomarkers for disease diagnoses, one of those being microRNA. microRNAs are a group of small RNA molecules with 18–24 nucleotides which have functions such as the degradation of oncogenes transcripted mRNA. The aim of this paper is to explore all theoretical possibilities that microRNA offers as an early diagnostic tool for oral cancer. Studies show that microRNA can be directly linked with cancer gene regulation. Because microRNA is more specific to tissues and diseases than mRNA, it holds the premise of being a feasible, non-invasive, and stable biomarker for early diagnosis of oral cancer. The fact that miRNA can be found in saliva makes it an extremely affordable and feasible option as a biomarker to be used. Since it is linked to regulating functions of cancer genes, it also brings hope that in the near future, it could be used as a reliable biomarker.

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Authors and Affiliations

  1. Department of Oral Pathology, University of Southern Santa Catarina, Tubarão, SC, Brazil

    J. S. Ghizoni

  2. Dental Department, Community Health Center, Leominster, MA, USA

    R. Nichele

  3. Department of Clinical Dentistry, University of Southern Santa Catarina, Tubarão, SC, Brazil

    M. T. de Oliveira

  4. Post-Graduate Program of Health Sciences, University of Southern Santa Catarina, Tubarão, SC, Brazil

    S. Pamato & J. R. Pereira

Authors
  1. J. S. Ghizoni
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  2. R. Nichele
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  3. M. T. de Oliveira
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  4. S. Pamato
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  5. J. R. Pereira
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Correspondence to S. Pamato.

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Ghizoni, J.S., Nichele, R., de Oliveira, M.T. et al. The utilization of saliva as an early diagnostic tool for oral cancer: microRNA as a biomarker. Clin Transl Oncol 22, 804–812 (2020). https://doi.org/10.1007/s12094-019-02210-y

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  • DOI: https://doi.org/10.1007/s12094-019-02210-y

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