Abstract
A series of 10 derivatives of 5-(5-amino-1,3,4-thiadiazole-2-yl)-3,4-dihydro-6-methyl-4-phenyl-pyrimidin-2(1H)-one and 10 derivatives of 3,4-dihydro-5-(5-mercapto-4H-1,2,4-triazol-3-yl)-6-methyl-4-phenyl pyrimidin-2(1H)-one have been synthesized. Among the synthesized derivatives, triazole substituted compounds have shown higher antibacterial inhibition when compared to the thiadiazole derivatives. All the structures of the newly synthesized compounds have been characterized by IR, 1H and 13C NMR, GC-MS and CHN analysis. Most of the compounds have shown promising antibacterial activity when compared with the standard drug ciprofloxacin.
A series of ten derivatives of 5-(5-amino-1,3,4-thiadiazole-2-yl)-3,4-dihydro-6-methyl-4-phenylpyrimidin-2(1H)-one and ten derivatives of 3,4-dihydro-5-(5-mercapto-4H-1,2,4-triazol-3-yl)-6-methyl-4-phenyl pyrimidin-2(1H)-one have been synthesized and structures characterized. Among the synthesized derivatives, triazole substituted compounds have shown higher antibacterial inhibition when compared to the thiadiazole derivatives.
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The authors are thankful to the Principal and Research Department of Chemistry, Islamiah College, Vaniyambadi, Vellore district, Tamil Nadu, India for constant encouragement and providing necessary facilities.
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All additional information pertaining to characterization of the compounds using FT-IR spectra (Figures S1 to S10 and S31 to S40), 1H NMR spectra (Figures S11 to S20 and S41 to S50), 13C NMR spectra (Figures S21 to S30 and S51 to S60), antibacterial screening data (Tables S1, S2) and antibacterial activities comparative diagram (Figure S1, S2 and S3) are given in the supporting information available at www.ias.ac.in/chemsci.
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ANDREWS, B., KOMATHI, K. & MOHAN, S. Synthesis and comparing the antibacterial activities of pyrimidine derivatives. J Chem Sci 129, 335–341 (2017). https://doi.org/10.1007/s12039-017-1228-z
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DOI: https://doi.org/10.1007/s12039-017-1228-z