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Sulfanilic acid functionalized mesoporous SBA-15: A water-tolerant solid acid catalyst for the synthesis of uracil fused spirooxindoles as antioxidant agents

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Abstract

Incorporating sulfanilic acid as a hydrophobic Brønsted acid inside the nanospaces of SBA-15 led to a water-tolerant solid acid catalyst, SBA-15-PhSO3H, which showed excellent catalytic performance in synthesis of uracil-fused spirooxindoles in aqueous ethanol. The synthesized compounds were evaluated for their antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging assay.

Green synthesis of uracil-fused spirooxindoles using sulfanilic acidfunctionalized SBA-15 as a reusable heterogeneous acid catalyst and the antioxidant activity of the synthesized compounds are described.

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Acknowledgements

We are thankful to the Research Council of Mazandaran University for the financial support of this work.

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Authors and Affiliations

  1. Department of Chemistry, University of Mazandaran, P. O. Box 47415, Babolsar, Iran

    ROBABEH BAHARFAR & RAZIEH AZIMI

Authors
  1. ROBABEH BAHARFAR
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  2. RAZIEH AZIMI
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Correspondence to ROBABEH BAHARFAR.

Additional information

Supplementary Information

All additional information relating to characterization of the catalyst using FT-IR, TGA, XRD and TEM techniques (figures S1–S4), 1H NMR and 13C NMR spectra for compounds 4a-j (figures S5-S24) are available in the supplementary information, which is available free of charge at www.ias.ac.in/chemsci.

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BAHARFAR, R., AZIMI, R. Sulfanilic acid functionalized mesoporous SBA-15: A water-tolerant solid acid catalyst for the synthesis of uracil fused spirooxindoles as antioxidant agents. J Chem Sci 127, 1389–1395 (2015). https://doi.org/10.1007/s12039-015-0910-2

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  • DOI: https://doi.org/10.1007/s12039-015-0910-2

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