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Antiplasmodial and larvicidal compounds of Toddalia asiatica root bark

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Abstract

From the n-hexane, ethyl acetate and methanol extracts of Toddalia asiatica root bark were isolated eight compounds (1–8) which were identified on the basis of both spectroscopic and physical data as well as comparison with already published results. The crude extracts and isolated compounds showed moderate in vitro antiplasmodial activity against D6 (chloroquine-sensitive) and W2 (chloroquine-resistant) strains of Plasmodium falciparum. The extracts and isolates also exhibited larvicidal activities against Aedes aegypti and coumarins were identified as the active compounds.

Chemical examination of Toddalia asiatica root bark resulted into the isolation of eight compounds which were evaluated for antiplasmodial and larvicidal activities. Toddaculatin (3) was the most active against chloroquine sensitive D6 strain of Plasmodium falciparum while toddanol (6) was found to be toxic against Aedes aegyti 2nd instar larvae.

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Acknowledgements

We acknowledge support from the Inter University Council for Eastern Africa (IUCEA) through VicRes for funding the project. Mr. S G Mathenge is thanked for the identification of the plant material. Prof. Lutz Tietze of Georg-August University Goettingen is also thanked for providing both NMR and MS analysis.

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Authors and Affiliations

  1. Department of Chemistry, Maseno University, P. O. Box 333-40105, Maseno, Kenya

    T NYAHANGA, J ISAAC JONDIKO & L ONYANGO AROT MANGURO

  2. Kenya Medical Research Institute, Centre for Traditional Medicine and Drug Research, P. O. Box 54840-00200, Nairobi, Kenya

    J ATIENO ORWA

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  1. T NYAHANGA
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  2. J ISAAC JONDIKO
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  3. L ONYANGO AROT MANGURO
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Correspondence to T NYAHANGA or L ONYANGO AROT MANGURO.

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NYAHANGA, T., JONDIKO, J.I., MANGURO, L.O.A. et al. Antiplasmodial and larvicidal compounds of Toddalia asiatica root bark. J Chem Sci 125, 1115–1121 (2013). https://doi.org/10.1007/s12039-013-0483-x

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  • DOI: https://doi.org/10.1007/s12039-013-0483-x

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