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RAGE-TLR Crosstalk Sustains Chronic Inflammation in Neurodegeneration

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Abstract

Chronic inflammatory reactions are consistenly present in neurodegeneration of Alzheimer type and are considered important factors that accelerate progression of the disease. Receptors of innate immunity participate in triggering and driving inflammatory reactions. For example, Toll-like receptors (TLRs) and receptor for advanced glycation end product (RAGE), major receptors of innate immunity, play a central role in perpetuation of inflammation. RAGE activation should be perceived as a primary mechanism which determines self-perpetuated chronic inflammation, and RAGE cooperation with TLRs amplifies inflammatory signaling. In this review, we highlight and discuss that RAGE-TLR crosstalk emerges as an important driving force of chronic inflammation in Alzheimer’s disease.

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Authors and Affiliations

  1. Department of Basic Medical Sciences, Wrocław Medical University, Wrocław, Poland

    Kazimierz Gąsiorowski & Barbara Brokos

  2. Facultad de Ciencias de la Salud, Universidad San Sebastián, Lientur, Concepción, Chile

    Valentina Echeverria

  3. Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá D.C., Colombia

    George E. Barreto

  4. Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Santiago, Chile

    George E. Barreto

  5. Clinic of Psychiatry, Wrocław Medical University, Pasteura 10, 50-367, Wrocław, Poland

    Jerzy Leszek

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  1. Kazimierz Gąsiorowski
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Gąsiorowski, K., Brokos, B., Echeverria, V. et al. RAGE-TLR Crosstalk Sustains Chronic Inflammation in Neurodegeneration. Mol Neurobiol 55, 1463–1476 (2018). https://doi.org/10.1007/s12035-017-0419-4

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