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Heat Shock Proteins and Toll-Like Receptors

  • Chapter
Toll-Like Receptors (TLRs) and Innate Immunity

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 183))

Researchers have only just begun to elucidate the relationship between heat shock proteins (HSP) and Toll-like receptors (TLR). HSP were originally described as an intracellular molecular chaperone of naïve, aberrantly folded, or mutated proteins and primarily implicated as a cytoprotective protein when cells are exposed to stressful stimuli. However, recent studies have ascribed novel functions to the Hsp70 protein depending on its localization: Surface-bound Hsp70 specifically activate natural killer (NK) cells, while Hsp70 released into the extracellular milieu specifically bind to Toll-like receptors (TLR) 2 and 4 on antigen-presenting cells (APC) and exerts immunoregulatory effects, including upregulation of adhesion molecules, co-stimulatory molecule expression, and cytokine and chemokine release—a process known as the chaperokine activity of Hsp70. This chapter discusses the most recent advances in the understanding of heat shock protein (HSP) and TLR interactions in general and highlights recent findings that demonstrate Hsp70 is a ligand for TLR and its biological significance.

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Authors and Affiliations

  1. Division of Investigative Pathology, Scott & White Memorial Hospital and Clinic and Texas A&M University System Health Science Center College of Medicine, 1901 South 1st Street, Temple, TX 76504, USA

    Alexzander Asea

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  1. Alexzander Asea
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  1. Institut für Immunologie BMFZ, Philipps-Universität Marburg, Hans-Meerwein-Str. 2, D-35043, Marburg, Germany

    Stefan Bauer

  2. Abteilung für Klinische Pharmakologie, Universitätsklinikum Bonn, Sigmund-Freud-Str. 25, D-53105, Bonn, Germany

    Gunther Hartmann

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Asea, A. (2008). Heat Shock Proteins and Toll-Like Receptors. In: Bauer, S., Hartmann, G. (eds) Toll-Like Receptors (TLRs) and Innate Immunity. Handbook of Experimental Pharmacology, vol 183. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72167-3_6

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