Abstract
Subarachnoid hemorrhage (SAH) is a devastating cerebrovascular event associated with high mortality and significant morbidity. Recent studies have highlighted the emerging role of ferroptosis, a novel form of regulated cell death, in the pathogenesis of SAH. Circular RNAs (circRNAs), have been found to play essential roles in various cellular processes, including gene regulation and disease pathogenesis. The expression profile of circRNAs in neural tissues, particularly in the brain, suggests their critical role in synaptic function and neurogenesis. Moreover, the interplay between circRNAs and ferroptosis-related pathways, such as iron metabolism and lipid peroxidation, is explored in the context of SAH. Understanding the functional roles of specific circRNAs in the context of SAH may provide potential therapeutic targets to attenuate ferroptosis-associated brain injury. Furthermore, the potential of circRNAs as diagnostic biomarkers for SAH severity, prognosis, and treatment response is discussed. Overall, this review highlights the significance of studying the intricate interplay between circRNAs and ferroptosis in the context of SAH. Unraveling the mechanisms by which circRNAs modulate ferroptotic cell death may pave the way for the development of novel therapeutic strategies and diagnostic approaches for SAH management, ultimately improving patient outcomes and quality of life.
Similar content being viewed by others
Data Availability
No Data associated in the manuscript.
References
Macdonald, R. L., & Schweizer, T. A. (2017). Spontaneous subarachnoid haemorrhage. Lancet, 389(10069), 655–66.
de Rooij, N. K., Linn, F. H., van der Plas, J. A., Algra, A., & Rinkel, G. J. (2007). Incidence of subarachnoid haemorrhage: A systematic review with emphasis on region, age, gender and time trends. Journal of Neurology, Neurosurgery & Psychiatry, 78(12), 1365–72.
Feigin, V. L., Lawes, C. M., Bennett, D. A., Barker-Collo, S. L., & Parag, V. (2009). Worldwide stroke incidence and early case fatality reported in 56 population-based studies: A systematic review. Lancet Neurol, 8(4), 355–69.
Cao, Y., Li, Y., He, C., Yan, F., Li, J. R., Xu, H. Z., et al. (2021). Selective ferroptosis inhibitor liproxstatin-1 attenuates neurological deficits and neuroinflammation after subarachnoid hemorrhage. Neuroscience Bulletin, 37(4), 535–49.
Wang, H., Zhou, Y., Zhao, M., Yu, L., Lin, Y., & Kang, D. (2023). Ferrostatin-1 attenuates brain injury in animal model of subarachnoid hemorrhage via phospholipase A2 activity of PRDX6. Neuroreport, 34(12), 606–16.
Balihodzic, A., Prinz, F., Dengler, M. A., Calin, G. A., Jost, P. J., & Pichler, M. (2022). Non-coding RNAs and ferroptosis: Potential implications for cancer therapy. Cell Death & Differentiation, 29(6), 1094–106.
Yang, J., Cao, X.-H., Luan, K.-F., & Huang, Y.-D. (2021). Circular RNA FNDC3B protects oral squamous cell carcinoma cells from ferroptosis and contributes to the malignant progression by regulating miR-520d-5p/SLC7A11 axis. Frontiers in Oncology, 11, 672724.
Xi, Y., Shen, Y., Wu, D., Zhang, J., Lin, C., Wang, L., et al. (2022). CircBCAR3 accelerates esophageal cancer tumorigenesis and metastasis via sponging miR-27a-3p. Molecular Cancer, 21(1), 1–20.
Liu, B., Ma, H., Liu, X., & Xing, W. (2023). CircSCN8A suppresses malignant progression and induces ferroptosis in non-small cell lung cancer by regulating miR-1290/ACSL4 axis. Cell Cycle, 22(7), 758–76.
Luo, Y., Huang, Q., He, B., Liu, Y., Huang, S., & Xiao, J. (2021). Regulation of ferroptosis by non-coding RNAs in the development and treatment of cancer (Review). Oncology Reports, 45(1), 29–48.
Weng, R., Jiang, Z., & Gu, Y. (2022). Noncoding RNA as diagnostic and prognostic biomarkers in cerebrovascular disease. Oxidative Medicine and Cellular Longevity, 2022, 8149701.
Chen, X., Yang, S., Yang, J., Liu, Q., Li, M., Wu, J., et al. (2021). Circular RNA circDUS2 Is a potential biomarker for intracranial aneurysm. Frontiers in Aging Neuroscience, 13, 632448.
Zhou, W.-Y., Cai, Z.-R., Liu, J., Wang, D.-S., Ju, H.-Q., & Xu, R.-H. (2020). Circular RNA: Metabolism, functions and interactions with proteins. Molecular Cancer, 19(1), 172.
Gan, B. (2021). Mitochondrial regulation of ferroptosis. Journal of Cell Biology, 220(9), e202105043.
Puig, S., Ramos-Alonso, L., Romero, A. M., & Martínez-Pastor, M. T. (2017). The elemental role of iron in DNA synthesis and repair. Metallomics, 9(11), 1483–500.
Galaris, D., Barbouti, A., & Pantopoulos, K. (2019). Iron homeostasis and oxidative stress: An intimate relationship. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1866(12), 118535.
Battaglia, A. M., Chirillo, R., Aversa, I., Sacco, A., Costanzo, F., & Biamonte, F. (2020). Ferroptosis and cancer: Mitochondria meet the “Iron Maiden” cell death. Cells, 9(6), 1505.
DeGregorio-Rocasolano, N., Martí-Sistac, O., Ponce, J., Castelló-Ruiz, M., Millán, M., Guirao, V., et al. (2018). Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage. Redox Biology, 15, 143–58.
Capelletti, M. M., Manceau, H., Puy, H., & Peoc’h, K. (2020). Ferroptosis in liver diseases: An overview. International Journal of Molecular Sciences, 21(14), 4908.
Zhang, N., Yu, X., Xie, J., & Xu, H. (2021). New insights into the role of ferritin in iron homeostasis and neurodegenerative diseases. Molecular Neurobiology, 58(6), 2812–23.
Abbate, V., & Hider, R. (2017). Iron in biology. Metallomics, 9(11), 1467–9.
Fontecave, M., & Pierre, J. L. (1993). Iron: Metabolism, toxicity and therapy. Biochimie, 75(9), 767–73.
Winterbourn, C. C. (1995). Toxicity of iron and hydrogen peroxide: The Fenton reaction. Toxicology Letters, 82–83, 969–74.
Hassannia, B., Vandenabeele, P., & Vanden, Berghe T. (2019). Targeting ferroptosis to iron out cancer. Cancer Cell, 35(6), 830–49.
Gaschler, M. M., & Stockwell, B. R. (2017). Lipid peroxidation in cell death. Biochemical and Biophysical Research Communications, 482(3), 419–25.
Lee, J.-Y., Keep, R. F., He, Y., Sagher, O., Hua, Y., & Xi, G. (2010). Hemoglobin and iron handling in brain after subarachnoid hemorrhage and the effect of deferoxamine on early brain injury. Journal of Cerebral Blood Flow & Metabolism, 30(11), 1793–803.
Zhang, H., Ostrowski, R., Jiang, D., Zhao, Q., Liang, Y., Che, X., et al. (2021). Hepcidin promoted ferroptosis through iron metabolism which is associated with DMT1 signaling activation in early brain injury following subarachnoid hemorrhage. Oxidative Medicine and Cellular Longevity, 2021, 9800794.
Kenny, E. M., Fidan, E., Yang, Q., Anthonymuthu, T. S., New, L. A., Meyer, E. A., et al. (2019). Ferroptosis contributes to neuronal death and functional outcome after traumatic brain injury. Critical Care Medicine, 47(3), 410–8.
Gomes, J. A., Selim, M., Cotleur, A., Hussain, M. S., Toth, G., Koffman, L., et al. (2014). Brain iron metabolism and brain injury following subarachnoid hemorrhage: iCeFISH-pilot (CSF iron in SAH). Neurocritical Care, 21(2), 285–93.
Galea, I., Durnford, A., Glazier, J., Mitchell, S., Kohli, S., Foulkes, L., et al. (2022). Iron deposition in the brain after aneurysmal subarachnoid hemorrhage. Stroke, 53(5), 1633–42.
Huang, Y., Wu, H., Hu, Y., Zhou, C., Wu, J., Wu, Y., et al. (2022). Puerarin attenuates oxidative stress and ferroptosis via AMPK/PGC1α/Nrf2 pathway after subarachnoid hemorrhage in rats. Antioxidants (Basel), 11(7), 1259.
Gao, S., Zhou, L., Lu, J., Fang, Y., Wu, H., Xu, W., et al. (2022). Cepharanthine attenuates early brain injury after subarachnoid hemorrhage in mice via inhibiting 15-lipoxygenase-1-mediated microglia and endothelial cell ferroptosis. Oxidative Medicine and Cellular Longevity, 2022, 4295208.
Liang, D., Minikes, A. M., & Jiang, X. (2022). Ferroptosis at the intersection of lipid metabolism and cellular signaling. Molecular Cell, 82(12), 2215–27.
Doll, S., Proneth, B., Tyurina, Y. Y., Panzilius, E., Kobayashi, S., Ingold, I., et al. (2017). ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nature Chemical Biology, 13(1), 91–8.
Cui, J., Wang, Y., Tian, X., Miao, Y., Ma, L., Zhang, C., et al. (2023). LPCAT3 is transcriptionally regulated by YAP/ZEB/EP300 and collaborates with ACSL4 and YAP to determine ferroptosis sensitivity. Antioxidants & Redox Signaling, 39, 491–511.
Dixon, S. J., Winter, G. E., Musavi, L. S., Lee, E. D., Snijder, B., Rebsamen, M., et al. (2015). Human haploid cell genetics reveals roles for lipid metabolism genes in nonapoptotic cell death. ACS Chemical Biology, 10(7), 1604–9.
Feng, H., & Stockwell, B. R. (2018). Unsolved mysteries: How does lipid peroxidation cause ferroptosis? PLoS Biology, 16(5), e2006203.
Liao, P., Wang, W., Wang, W., Kryczek, I., Li, X., Bian, Y., et al. (2022). CD8(+) T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4. Cancer Cell, 40(4), 365–78.e6.
Hirashima, Y., Doshi, M., Hayashi, N., Endo, S., Akazawa, Y., Shichiri, M., et al. (2012). Plasma platelet-activating factor-acetyl hydrolase activity and the levels of free forms of biomarker of lipid peroxidation in cerebrospinal fluid of patients with aneurysmal subarachnoid hemorrhage. Neurosurgery, 70(3), 602–9.
Li, Y., Liu, Y., Wu, P., Tian, Y., Liu, B., Wang, J., et al. (2021). Inhibition of ferroptosis alleviates early brain injury after subarachnoid hemorrhage in vitro and in vivo via reduction of lipid peroxidation. Cellular and Molecular Neurobiology, 41(2), 263–78.
Fan, B. Y., Pang, Y. L., Li, W. X., Zhao, C. X., Zhang, Y., Wang, X., et al. (2021). Liproxstatin-1 is an effective inhibitor of oligodendrocyte ferroptosis induced by inhibition of glutathione peroxidase 4. Neural Regeneration Research, 16(3), 561–6.
Qu, X. F., Liang, T. Y., Wu, D. G., Lai, N. S., Deng, R. M., Ma, C., et al. (2021). Acyl-CoA synthetase long chain family member 4 plays detrimental role in early brain injury after subarachnoid hemorrhage in rats by inducing ferroptosis. CNS Neuroscience & Therapeutics, 27(4), 449–63.
Jiao, D., Xu, J., Lou, C., Luo, Y., Ni, C., Shen, G., et al. (2023). Quercetin alleviates subarachnoid hemorrhage-induced early brain injury via inhibiting ferroptosis in the rat model. Anatomical Record (Hoboken), 306(3), 638–50.
Zhang, X.-S., Lu, Y., Tao, T., Wang, H., Liu, G.-J., Liu, X.-Z., et al. (2020). Fucoxanthin mitigates subarachnoid hemorrhage-induced oxidative damage via sirtuin 1-dependent pathway. Molecular Neurobiology, 57(12), 5286–98.
Zheng, B., Zhou, X., Pang, L., Che, Y., & Qi, X. (2021). Baicalin suppresses autophagy-dependent ferroptosis in early brain injury after subarachnoid hemorrhage. Bioengineered, 12(1), 7794–804.
Zhang, X., Wu, Q., Lu, Y., Wan, J., Dai, H., Zhou, X., et al. (2018). Cerebroprotection by salvianolic acid B after experimental subarachnoid hemorrhage occurs via Nrf2- and SIRT1-dependent pathways. Free Radical Biology and Medicine, 124, 504–16.
Liu, M. R., Zhu, W. T., & Pei, D. S. (2021). System Xc(-): A key regulatory target of ferroptosis in cancer. Investigational New Drugs, 39(4), 1123–31.
Tang, D., & Kroemer, G. (2020). Ferroptosis. Current Biology, 30(21), R1292-r7.
Liu, Y., Fang, Y., Zhang, Z., Luo, Y., Zhang, A., Lenahan, C., et al. (2022). Ferroptosis: An emerging therapeutic target in stroke. Journal of Neurochemistry, 160(1), 64–73.
Pan, F., Xu, W., Ding, J., & Wang, C. (2022). Elucidating the progress and impact of ferroptosis in hemorrhagic stroke. Frontiers in Cell Neuroscience, 16, 1067570.
Guo, Y., Liu, X., Liu, D., Li, K., Wang, C., Liu, Y., et al. (2019). Inhibition of BECN1 suppresses lipid peroxidation by increasing system Xc- activity in early brain injury after subarachnoid hemorrhage. Journal of Molecular Neuroscience, 67(4), 622–31.
Bersuker, K., Hendricks, J. M., Li, Z., Magtanong, L., Ford, B., Tang, P. H., et al. (2019). The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature, 575(7784), 688–92.
Yuan, B., Zhao, X.-D., Shen, J.-D., Chen, S.-J., Huang, H.-Y., Zhou, X.-M., et al. (2022). Activation of SIRT1 alleviates ferroptosis in the early brain injury after subarachnoid hemorrhage. Oxidative Medicine and Cellular Longevity, 2022, 9069825.
Mishima, E., Ito, J., Wu, Z., Nakamura, T., Wahida, A., Doll, S., et al. (2022). A non-canonical vitamin K cycle is a potent ferroptosis suppressor. Nature, 608(7924), 778–83.
Huang, Y., Wu, H., Hu, Y., Zhou, C., Wu, J., Wu, Y., et al. (2022). Puerarin attenuates oxidative stress and ferroptosis via AMPK/PGC1α/Nrf2 pathway after subarachnoid hemorrhage in rats. Antioxidants (Basel), 11(7), 1259.
Gao, S., Zhou, L., Lu, J., Fang, Y., Wu, H., Xu, W., et al. (2022). Cepharanthine attenuates early brain injury after subarachnoid hemorrhage in mice via inhibiting 15-lipoxygenase-1-mediated microglia and endothelial cell ferroptosis. Oxidative Medicine and Cellular Longevity, 2022, 4295208.
Cao, Y., Li, Y., He, C., Yan, F., Li, J.-R., Xu, H.-Z., et al. (2021). Selective Ferroptosis inhibitor liproxstatin-1 attenuates neurological deficits and neuroinflammation after subarachnoid hemorrhage. Neuroscience Bulletin, 37(4), 535–49.
Chen, L.-L., & Yang, L. (2015). Regulation of circRNA biogenesis. RNA Biology, 12(4), 381–8.
Zhang, X., Wang, S., Wang, H., Cao, J., Huang, X., Chen, Z., et al. (2019). Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway. Molecular Cancer, 18(1), 20.
Zang, J., Lu, D., & Xu, A. (2020). The interaction of circRNAs and RNA binding proteins: An important part of circRNA maintenance and function. Journal of Neuroscience Research, 98(1), 87–97.
Liu, Z., Wang, Q., Wang, X., Xu, Z., Wei, X., & Li, J. (2020). Circular RNA cIARS regulates ferroptosis in HCC cells through interacting with RNA binding protein ALKBH5. Cell Death Discovery, 6(1), 72.
Zhou, X., Zhan, L., Huang, K., & Wang, X. (2020). The functions and clinical significance of circRNAs in hematological malignancies. Journal of Hematology & Oncology, 13(1), 138.
Li, F., Li, P.-F., & Hao, X.-D. (2023). Circular RNAs in ferroptosis: Regulation mechanism and potential clinical application in disease. Frontiers in Pharmacology, 14, 1173040.
Yang, R., Ma, L., Wan, J., Li, Z., Yang, Z., Zhao, Z., et al. (2023). Ferroptosis-associated circular RNAs: Opportunities and challenges in the diagnosis and treatment of cancer. Frontiers in Cell and Developmental Biology, 11, 1160381.
Xing, N., Du, Q., Guo, S., Xiang, G., Zhang, Y., Meng, X., et al. (2023). Ferroptosis in lung cancer: A novel pathway regulating cell death and a promising target for drug therapy. Cell Death Discovery, 9(1), 110.
Jin, J., Wang, Y., Zheng, D., Liang, M., & He, Q. (2022). A novel identified circular RNA, mmu_mmu_circRNA_0000309, involves in germacrone-mediated improvement of diabetic nephropathy through regulating ferroptosis by targeting miR-188-3p/GPX4 signaling axis. Antioxidants & Redox Signaling, 36(10–12), 740–59.
Wang, H.-H., Ma, J.-N., & Zhan, X.-R. (2021). Circular RNA Circ_0067934 attenuates ferroptosis of thyroid cancer cells by miR-545-3p/SLC7A11 signaling. Frontiers in Endocrinology, 12, 670031.
Pan, C.-F., Wei, K., Ma, Z.-J., He, Y.-Z., Huang, J.-J., Guo, Z.-Z., et al. (2022). CircP4HB regulates ferroptosis via SLC7A11-mediated glutathione synthesis in lung adenocarcinoma. Translational Lung Cancer Research, 11(3), 366–80.
Zhang, X., Xu, Y., Ma, L., Yu, K., Niu, Y., Xu, X., et al. (2022). Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma. Cancer Communications, 42(4), 287–313.
Wang, Y., Chen, H., & Wei, X. (2021). Circ_0007142 downregulates miR-874-3p-mediated GDPD5 on colorectal cancer cells. European Journal of Clinical Investigation, 51(7), e13541.
Li, F., Li, P.-F., & Hao, X.-D. (2023). Circular RNAs in ferroptosis: Regulation mechanism and potential clinical application in disease. Frontiers In Pharmacology, 14, 1173040.
Jin, J., Wang, Y., Zheng, D., Liang, M., & He, Q. (2022). A novel identified circular RNA, mmu_mmu_circRNA_0000309, involves in germacrone-mediated improvement of diabetic nephropathy through regulating ferroptosis by targeting miR-188-3p/GPX4 signaling axis. Antioxidants & Redox Signaling, 36(10–12), 740–59.
Chen, X., Kang, R., Kroemer, G., & Tang, D. (2021). Broadening horizons: The role of ferroptosis in cancer. Nature Reviews Clinical Oncology, 18(5), 280–96.
Koppula, P., Zhuang, L., & Gan, B. (2021). Cystine transporter SLC7A11/xCT in cancer: Ferroptosis, nutrient dependency, and cancer therapy. Protein & Cell, 12(8), 599–620.
Wang, Z.-Y., Wen, Z.-J., Xu, H.-M., Zhang, Y., & Zhang, Y.-F. (2022). Exosomal noncoding RNAs in central nervous system diseases: Biological functions and potential clinical applications. Frontiers in Molecular Neuroscience, 15, 1004221.
Bazhabayi, M., Qiu, X., Li, X., Yang, A., Wen, W., Zhang, X., et al. (2021). CircGFRA1 facilitates the malignant progression of HER-2-positive breast cancer via acting as a sponge of miR-1228 and enhancing AIFM2 expression. Journal of Cellular and Molecular Medicine, 25(21), 10248–56.
Ou, R., Lu, S., Wang, L., Wang, Y., Lv, M., Li, T., et al. (2022). Circular RNA circLMO1 suppresses cervical cancer growth and metastasis by triggering miR-4291/ACSL4-mediated ferroptosis. Frontiers in Oncology, 12, 858598.
Mao, R., & Liu, H. (2022). Depletion of mmu_circ_0001751 (circular RNA Carm1) protects against acute cerebral infarction injuries by binding with microRNA-3098-3p to regulate acyl-CoA synthetase long-chain family member 4. Bioengineered, 13(2), 4063–75.
Wu, Q., Deng, Z., Pan, X., Shen, H.-B., Choi, K.-S., Wang, S., et al. (2022). MDGF-MCEC: A multi-view dual attention embedding model with cooperative ensemble learning for CircRNA-disease association prediction. Briefings in Bioinformatics, 23(5), bbac289.
Zheng, J., Sato, M., Mishima, E., Sato, H., Proneth, B., & Conrad, M. (2021). Sorafenib fails to trigger ferroptosis across a wide range of cancer cell lines. Cell Death & Disease, 12(7), 698.
Jiang, M., Mo, R., Liu, C., & Wu, H. (2022). Expression of Concern: Circ_0000190 sponges miR-382-5p to suppress cell proliferation and motility and promote cell death by targeting ZNRF3 in gastric cancer. Journal of Biochemistry.
Jiang, M., Mo, R., Liu, C., & Wu, H. (2022). Circ_0000190 sponges miR-382-5p to suppress cell proliferation and motility and promote cell death by targeting ZNRF3 in gastric cancer. Journal of Biochemistry.
Arabpour, J., Rezaei, K., Khojini, J. Y., Razi, S., Hayati, M. J., & Gheibihayat, S. M. (2024). The potential role and mechanism of circRNAs in ferroptosis: A comprehensive review. Pathology-Research and Practice, 255, 155203.
Wu, C., Du, M., Yu, R., Cheng, Y., Wu, B., Fu, J., et al. (2022). A novel mechanism linking ferroptosis and endoplasmic reticulum stress via the circPtpn14/miR-351-5p/5-LOX signaling in melatonin-mediated treatment of traumatic brain injury. Free Radical Biology and Medicine, 178, 271–94.
Jiang, Y., Zhao, J., Li, R., Liu, Y., Zhou, L., Wang, C., et al. (2022). CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis. Journal of Experimental & Clinical Cancer Research, 41(1), 307.
Wu, N., Zhu, D., Li, J., Li, X., Zhu, Z., Rao, Q., et al. (2023). CircOMA1 modulates cabergoline resistance by downregulating ferroptosis in prolactinoma. Journal of Endocrinological Investigation, 46(8), 1573–87.
Wu, X. B., Wu, Y. T., Guo, X. X., Xiang, C., Chen, P. S., Qin, W., et al. (2022). Circular RNA hsa_circ_0007990 as a blood biomarker for unruptured intracranial aneurysm with aneurysm wall enhancement. Frontiers in Immunology, 13, 1061592.
Chen, X., Yang, S., Yang, J., Liu, Q., Li, M., Wu, J., et al. (2021). Circular RNA circDUS2 is a potential biomarker for intracranial aneurysm. Frontiers in Aging Neuroscience, 13, 632448.
Huang, Q., Sun, Y., Huang, Q., Zeng, Y., Lin, S., Huang, S., et al. (2021). Association between circular RNAs and intracranial aneurysm rupture under the synergistic effect of individual environmental factors. Frontiers in Neurology, 12, 594835.
Ma, Y., Zhang, B., Zhang, D., Wang, S., Li, M., & Zhao, J. (2021). Differentially expressed circular RNA profile in an intracranial aneurysm group compared with a healthy control group. Disease Markers, 2021, 8889569.
Cao, H., Chen, J., Lai, X., Liu, T., Qiu, P., Que, S., et al. (2021). Circular RNA expression profile in human primary multiple intracranial aneurysm. Experimental and Therapeutic Medicine, 21(3), 239.
Wu, C., Du, M., Yu, R., Cheng, Y., Wu, B., Fu, J., et al. (2022). A novel mechanism linking ferroptosis and endoplasmic reticulum stress via the circPtpn14/miR-351-5p/5-LOX signaling in melatonin-mediated treatment of traumatic brain injury. Free Radical Biology and Medicine, 178, 271–94.
Jiang, Y., Zhao, J., Li, R., Liu, Y., Zhou, L., Wang, C., et al. (2022). CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis. Journal of Experimental & Clinical Cancer Research, 41(1), 307.
Wu, N., Zhu, D., Li, J., Li, X., Zhu, Z., Rao, Q., et al. (2023). CircOMA1 modulates cabergoline resistance by downregulating ferroptosis in prolactinoma. Journal of Endocrinological Investigation, 46(8), 1573–87.
Wu, X.-B., Wu, Y.-T., Guo, X.-X., Xiang, C., Chen, P.-S., Qin, W., et al. (2022). Circular RNA hsa_circ_0007990 as a blood biomarker for unruptured intracranial aneurysm with aneurysm wall enhancement. Frontiers in Immunology, 13, 1061592.
Acknowledgements
Not applicable.
Funding
Not applicable.
Author information
Authors and Affiliations
Contributions
YS: Conceptualization, Writing − original draft preparation, Writing − review & editing. XL: Data curation. LY: Writing − review & editing. YC: Writing − review & editing, Data curation. XM: Writing − review & editing
Corresponding author
Ethics declarations
Competing interests
The authors have no competing conflicts of interests to declare.
Consent for Publication
Not applicable.
Ethics Approval
Not applicable.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Song, Y., Luo, X., Yao, L. et al. Exploring the Role of Ferroptosis-Related Circular RNAs in Subarachnoid Hemorrhage. Mol Biotechnol (2024). https://doi.org/10.1007/s12033-024-01140-7
Received:
Accepted:
Published:
DOI: https://doi.org/10.1007/s12033-024-01140-7