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An Anecdote on Prospective Protein Targets for Developing Novel Plant Growth Regulators

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Abstract

Phytohormones are the main regulatory molecules of core signalling networks associated with plant life cycle regulation. Manipulation of hormone signalling cascade enables the control over physiological traits of plant, which has major applications in field of agriculture and food sustainability. Hence, stable analogues of these hormones are long sought after and many of them are currently known, but the quest for more effective, stable and economically viable analogues is still going on. This search has been further strengthened by the identification of the components of signalling cascade such as receptors, downstream cascade members and transcription factors. Furthermore, many proteins of phytohormone cascades are available in crystallized forms. Such crystallized structures can provide the basis for identification of novel interacting compounds using in silico approach. Plenty of computational tools and bioinformatics software are now available that can aid in this process. Here, the metadata of all the major phytohormone signalling cascades are presented along with discussion on major protein–ligand interactions and protein components that may act as a potential target for manipulation of phytohormone signalling cascade. Furthermore, structural aspects of phytohormones and their known analogues are also discussed that can provide the basis for the synthesis of novel analogues.

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Acknowledgements

Authors are thankful to Department of Microbiology and Biotechnology, School of Sciences, Gujarat University, DST-FIST Sponsored Department, for providing necessary facilities to perform experiments. We acknowledge Education Department, Government of Gujarat, India for the providing research fellowship to Rohit Patel and Krina Mehta under the ScHeme Of Developing High-quality research (SHODH).

Funding

Authors are also thankful to UGC (Start-up Research Grant) for providing fund under the F.30–521/2020(BSR), Under Secretary FD-III Section, University Grant Commission, New Delhi 110002.

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  1. Department of Microbiology & Biotechnology, University School of Sciences, Gujarat University, Ahmedabad, Gujarat, 380009, India

    Rohit Patel, Krina Mehta, Dweipayan Goswami & Meenu Saraf

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RP and KM wrote the first draft. DG and MS finalized the manuscript.

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Patel, R., Mehta, K., Goswami, D. et al. An Anecdote on Prospective Protein Targets for Developing Novel Plant Growth Regulators. Mol Biotechnol 64, 109–129 (2022). https://doi.org/10.1007/s12033-021-00404-w

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