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Synthesis, characterization, antioxidant and anticancer activities of a new Schiff base and its M(II) complexes derived from 5-fluorouracil

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Abstract

In this study, Schiff base ligand was obtained from the condensation reaction of benzene-1,2-diamine and 5-fluoropyrimidine-2,4(1H,3H)-dione (5-FU). Metal(II) complexes were synthesized with Fe(II), Co(II) and Ni(II) chloride salts. The synthesized ligand and metal complexes were characterized by FT-IR, UV–vis, 1H-13C NMR, elemental analyses, mass spectroscopy, magnetic moments, molar conductivity and thermogravimetric analysis studies. With the help of different techniques reveal Fe(II), Co(II) and Ni(II) complexes have exhibited tetrahedral and octahedral geometry. Ligand acted as bidentate and it binds metal(II) ions through deprotonated-NH, imine-N atom and carbonyl-O atom, respectively. DPPH, ABTS, FRAP, CUPRAC and total antioxidant activity methods were used to determine the antioxidant properties of ligand and metal complexes. According to the results, the synthesized compounds showed very high antioxidant activity compared to 5-FU. The cytotoxicities of the synthesized compounds were performed on MCF-7 (human breast cancer) and L-929 (fibroblast) cell lines using the MTT assay. In addition, the effect of electroporation (EP) on the cytotoxicity of the compounds was investigated. Our results demonstrated that novel Co(II) and Ni(II) complexes show potential as new anticancer agents and ECT may be a viable treatment option for breast cancer.

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Authors and Affiliations

  1. Department of Molecular Biology and Genetics, Faculty of Art and Science, Mus Alparslan University, 49250, Mus, Turkey

    Ahmet Savcı & Yusuf Alan

  2. Department of Medical Services and Techniques, Health Services Vocational School, Mus Alparslan University, 49250, Mus, Turkey

    Kenan Buldurun

  3. Department of Occupational Health and Safety, Faculty of Health Sciences, Mus Alparslan University, 49250, Mus, Turkey

    Mehmet Eşref Alkış

  4. Department of Chemistry, Faculty of Arts and Sciences, Mus Alparslan University, 49250, Mus, Turkey

    Nevin Turan

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Savcı, A., Buldurun, K., Alkış, M.E. et al. Synthesis, characterization, antioxidant and anticancer activities of a new Schiff base and its M(II) complexes derived from 5-fluorouracil. Med Oncol 39, 172 (2022). https://doi.org/10.1007/s12032-022-01774-0

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