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Synthesis, characterization, antioxidant, antimicrobial and DNA binding properties of ruthenium(II), cobalt(II) and nickel(II) complexes of Schiff base containing o-vanillin

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Abstract

In this study, the complex combinations of Ru(II), Co(II) and Ni(II) with Schiff base obtained through the condensation of (E)-methyl 2-amino-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate with 2-hydroxy-3-methoxybenzaldehyde (o-vanillin) were prepared. The characterization of newly developed complexes was implemented by IR, elemental analyses, magnetic susceptibility, mass spectra, UV–Vis and thermogravimetry/differential thermal analysis. The X-ray powder diffraction pattern of the complexes was also investigated. The geometries of the complexes were found to be octahedral. Furthermore, antioxidant, antimicrobial and pBR322 plasmid DNA cleavage activities were investigated. The antibacterial effects of the Co(II) complex on Gram-positive and Gram-negative bacteria were identified to be higher than those of ligand. The Ru(II) complex was found to have higher radical scavenging potential on 1,1-diphenyl-2-picryl-hydrazyl (DPPH·), superoxide anion (O2−), hydroxyl (OH) and 2,2′-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radicals, in comparison with ligand. The binding affinity of the Ni(II) complex was higher than that of ligand.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Arts and Sciences, Muş Alparslan University, Muş, Turkey

    Nevin Turan

  2. Department of Food Processing, Technical Science Vocational School, Muş Alparslan University, Muş, Turkey

    Kenan Buldurun

  3. Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Muş Alparslan University, Muş, Turkey

    Yusuf Alan & Ahmet Savci

  4. Department of Chemistry, Faculty of Arts and Sciences, Hitit University, Çorum, Turkey

    Naki Çolak

  5. Department of Physics, Faculty of Arts and Sciences, Muş Alparslan University, Muş, Turkey

    Asim Mantarcı

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  1. Nevin Turan
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Turan, N., Buldurun, K., Alan, Y. et al. Synthesis, characterization, antioxidant, antimicrobial and DNA binding properties of ruthenium(II), cobalt(II) and nickel(II) complexes of Schiff base containing o-vanillin. Res Chem Intermed 45, 3525–3540 (2019). https://doi.org/10.1007/s11164-019-03806-3

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