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Updated Meta-Analysis of BIN1, CR1, MS4A6A, CLU, and ABCA7 Variants in Alzheimer’s Disease

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Abstract

Genome-wide association studies (GWAS) have associated several genetic variants with late-onset Alzheimer’s disease (LOAD), a neurodegenerative disease. Among those, rs3764650 ABCA7, rs6656401 CR1, and rs744373 BIN1 were associated as risk factors for LOAD, while rs11136000 CLU and rs610932 MS4A6A were protective. Recently, several case-control studies have investigated the association of these polymorphisms with AD. However, not all meta-analyses analyzed these variants across different ethnic groups. Therefore, we performed an updated meta-analysis of rs3764650 ABCA7, rs6656401 CR1, rs744373 BIN1, rs11136000 CLU, and rs610932 MS4A6A variants associated with LOAD, considering different ethnic populations. We utilized samples from 38 articles, comprising a total of 24,771 patients and 35,324 controls obtained through the PubMed database. Odds ratios (ORs) with 95% confidence intervals (CI) for polymorphisms were calculated by allelic comparison as an additive genetic model. We validated the risk for LOAD with BIN1 (rs744373), CR1 (rs6656401), and ABCA7 (rs376465), as well as the protective association for MS4A6A (rs610932) and CLU (rs11136000) variants.

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Acknowledgments

We value the assistance and technical support for research on the Núcleo de Genética Humana e Molecular – NGHM, Brazil.

Funding

This study was financially supported by Universidade Federal do Espírito Santo – UFES; Fundo de Amparo e Pesquisa do Espírito Santo – FAPES; Departamento de Ciência e Tecnologia do Ministério da Saúde – Decit; Secretaria de Ciência, Tecnologia e Insumos Estratégicos do Ministério da Saúde – SCTIE/MS; Fundo de Apoio à Ciência e Tecnologia do Município de Vitória – FACITEC; Ministério da Ciência, Tecnologia e Inovação – MCTI; Conselho Nacional de Desenvolvimento Científico e Tecnológico – CNPQ; Ministério da Educação – MEC; and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – CAPES.

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Authors and Affiliations

  1. Núcleo de Genética Humana e Molecular, Departamento de Ciências Biológicas, Centro de Ciências Humanas e Naturais, Universidade Federal do Espírito Santo, Vitória, ES, Brazil

    Jucimara Ferreira Figueiredo Almeida, Lígia Ramos dos Santos, Maira Trancozo & Flavia de Paula

  2. Programa de Pós-Graduação em Biotecnologia, Universidade Federal do Espírito Santo, Vitória, ES, Brazil

    Jucimara Ferreira Figueiredo Almeida, Maira Trancozo & Flavia de Paula

  3. Laboratório de Genética Humana e Molecular, Departamento de Ciências Biológicas, CCHN, Universidade Federal do Espírito Santo, Av. Fernando Ferrari, 514, Prédio Lydia Behar, sala 102, Vitória, ES, 29075-910, Brazil

    Jucimara Ferreira Figueiredo Almeida

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  1. Jucimara Ferreira Figueiredo Almeida
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Jucimara Ferreira Figueiredo Almeida, Lígia Ramos dos Santos, Maira Trancozo, and Flavia de Paula wrote the manuscript and read and accepted the manuscript before submission. Jucimara Ferreira Figueiredo Almeida, Lígia Ramos dos Santos, and Maira Trancozo performed the meta-analysis, the literature search, and data extraction and evaluated the inclusion and exclusion criteria.

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Correspondence to Jucimara Ferreira Figueiredo Almeida.

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Almeida, J.F.F., dos Santos, L.R., Trancozo, M. et al. Updated Meta-Analysis of BIN1, CR1, MS4A6A, CLU, and ABCA7 Variants in Alzheimer’s Disease. J Mol Neurosci 64, 471–477 (2018). https://doi.org/10.1007/s12031-018-1045-y

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