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Association of NAD(P)H:Quinone Oxidoreductase 1 Polymorphism and Alzheimer’s Disease in Chinese

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Abstract

Several lines of evidence support a role of oxidative stress in the pathology of Alzheimer’s disease (AD). NAD(P)H:quinone oxidoreductase 1 (NQO1) catalyzes the two-electron reduction of quinones, preventing their participation in redox cycling and subsequent generation of reactive oxygen species. We examined association between the NQO1 C609T gene polymorphism and sporadic AD in a Chinese population comprising 311 AD patients and 330 controls. Our results showed a higher T-allele frequency in the AD cases compared with the controls. The difference was close to but did not reach statistically significant level [p = 0.059; odds ratio (OR) T versus C = 1.236; 95% confidence interval (95% CI), 0.992–1.540]. A significantly low C/C genotype frequency in the AD cases compared with the controls was detected (p = 0.025; OR C/C versus C/T + T/T = 0.674; 95% CI, 1.049–2.098) and APOE ε4 status analysis revealed significant difference in the APOE ε4 non-carriers (p = 0.036; OR = 0.633; 95% CI, 1.027–2.427). In the ≥65 years samples, significantly low C/C frequency in the AD cases in comparison with the controls was observed in the APOE ε4 non-carriers (p = 0.045; OR = 0.595; 95% CI, 1.010–2.794). These results indicated that the C/C genotype had a possible protective effect against AD development, and the T allele might be a weak risk factor for late onset AD.

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Acknowledgments

This work was supported by National Basic Research Program of China (no. 2007CB946902) and China Medical Board of New York (no. 99-699).

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Authors and Affiliations

  1. National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, People’s Republic of China

    Jian-Tao Bian, Hua-Lu Zhao, Xiu-Hua Bi & Jun-Wu Zhang

  2. Department of Neurology, Peking Union Medical Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, 100730, People’s Republic of China

    Zhen-Xin Zhang

  3. 5 Dong Dan San Tiao, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, People’s Republic of China

    Jun-Wu Zhang

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  1. Jian-Tao Bian
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  2. Hua-Lu Zhao
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Correspondence to Jun-Wu Zhang.

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J-T Bian and H-L Zhao contributed equally to the work.

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Bian, JT., Zhao, HL., Zhang, ZX. et al. Association of NAD(P)H:Quinone Oxidoreductase 1 Polymorphism and Alzheimer’s Disease in Chinese. J Mol Neurosci 34, 235–240 (2008). https://doi.org/10.1007/s12031-008-9036-z

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  • DOI: https://doi.org/10.1007/s12031-008-9036-z

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