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MAEL Cancer-Testis Antigen as a Diagnostic Marker in Primary Stages of Gastric Cancer with Helicobacter pylori Infection

  • Original Research
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Journal of Gastrointestinal Cancer Aims and scope Submit manuscript

Abstract

Purpose

Gastric cancer (GC) is the third leading cause of cancer related deaths in the world. Cancer testis antigens (CTAs) are involved in tumor progression of various cancers. These markers have not any expression or minimally expression in normal tissues, highlighting them as efficient methods for molecular targeted therapy. In the present study, we assessed the role of MAEL as a CTA in biology of GC and risk of Helicobacter Pylori (H pylori) infection.

Methods

Levels of MAEL mRNA expression in 80 GC tumor tissues were compared to their corresponding normal margins using the real-time polymerase chain reaction.

Results

There was a significant correlation between MAEL expression and tumor stage (p = 0.050). There were also significant correlations between MAEL expression and tumor grade (p = 0.015) and depth of invasion (p = 0.030) among the H pylori negative cases.

Conclusions

MAEL is probably associated with aggressiveness of primary-stage tumors and can be introduced as an efficient marker for the early detection and also H pylori infected tumors in GC patients.

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Authors and Affiliations

  1. Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Mohammad Reza Abbaszadegan & Negin Taghehchian

  2. Medical Genetics Research Center, Faculty of Medical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran

    Mohammad Reza Abbaszadegan & Azadeh Aarabi

  3. Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Meysam Moghbeli

Authors
  1. Mohammad Reza Abbaszadegan
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  2. Negin Taghehchian
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  3. Azadeh Aarabi
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  4. Meysam Moghbeli
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Correspondence to Meysam Moghbeli.

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The authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

This project was approved by the ethics committee of Mashhad University of Medical Sciences.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

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Abbaszadegan, M.R., Taghehchian, N., Aarabi, A. et al. MAEL Cancer-Testis Antigen as a Diagnostic Marker in Primary Stages of Gastric Cancer with Helicobacter pylori Infection. J Gastrointest Canc 51, 17–22 (2020). https://doi.org/10.1007/s12029-018-0183-3

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  • DOI: https://doi.org/10.1007/s12029-018-0183-3

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