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Role of Msi1 and PYGO2 in esophageal squamous cell carcinoma depth of invasion

  • RESEARCH ARTICLE
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Journal of Cell Communication and Signaling Aims and scope

Abstract

Deregulation of developmental signaling pathways such as Wnt/b-catenin and NOTCH are commonly observed in different cancers. A normal wnt pathway is essential for development and tissue homeostasis to preserve a normal balance between the differentiation and proliferation. PYGO2 is the main transcription factor of wnt pathway, while Msi1 is one of the wnt inhibitors. In this study we assessed the correlation between Msi1 and PYGO2 mRNA expression using Real time polymerase chain reaction in 48 esophageal squamous cell carcinoma (ESCC) patients. Although, there was not any significant correlation between the levels of Msi1 and PYGO2 mRNA expression, we observed a significant correlation between the Msi1 and PYGO2 overexpressed cases and depth of tumor invasion (p = 0.05). In conclusion, despite the role of these markers in tumor depth of invasion there is not any feedback between Msi1 and PYGO2 gene expression in ESCC.

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Acknowledgments

This work was supported by a grant from the Vice Chancellor for Research at Mashhad University of Medical Sciences, and was part of a Ph.D. student’s dissertation, No. 921202.

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Authors and Affiliations

  1. Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Meysam Moghbeli & Mohammad Reza Abbaszadegan

  2. Cardiothoracic Surgery and Transplant Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Ali Sadrizadeh

  3. Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran

    Mohammad Mahdi Forghanifard

  4. Department of Gastroenterology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

    Hooman Mosannen Mozaffari

  5. Department of Anesthesiology and Critical Care, Mashhad University of Medical Sciences, Mashhad, Iran

    Ebrahim Golmakani

  6. Medical Genetics Research Center, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran

    Mohammad Reza Abbaszadegan

Authors
  1. Meysam Moghbeli
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  2. Ali Sadrizadeh
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  3. Mohammad Mahdi Forghanifard
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  4. Hooman Mosannen Mozaffari
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  5. Ebrahim Golmakani
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  6. Mohammad Reza Abbaszadegan
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Correspondence to Mohammad Reza Abbaszadegan.

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Moghbeli, M., Sadrizadeh, A., Forghanifard, M.M. et al. Role of Msi1 and PYGO2 in esophageal squamous cell carcinoma depth of invasion. J. Cell Commun. Signal. 10, 49–53 (2016). https://doi.org/10.1007/s12079-015-0314-6

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  • DOI: https://doi.org/10.1007/s12079-015-0314-6

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