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Respiratory dendritic cells: mediators of tolerance and immunity

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Abstract

The respiratory tract is under constant bombardment from both innocuous and pathogenic material. The decision of how to respond to these challenges is mediated by a specialized set of antigen presenting cells within the lungs called dendritic cells (DC). Proper respiratory homeostasis requires that these respiratory DC (rDC) utilize both the local lung inflammatory environment as well as recognition of pathogen-specific patterns to determine whether to maintain homeostasis by either driving tolerance or immunity to the inhaled material. This review will focus on rDC and highlight how rDC regulate tolerance and immunity.

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Acknowledgments

We thank Dr. Steven Varga, Jodi McGill, and Michelle Edsen for critical reading of this manuscript. This work was supported by University of Iowa Department of Pathology Startup funds to KLL.

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  1. Department of Pathology, Immunology Graduate Program, University of Iowa, Iowa City, IA, 52242, USA

    Ryan A. Langlois & Kevin L. Legge

  2. Department of Pathology (1036ML), Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA

    Kevin L. Legge

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  1. Ryan A. Langlois
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Correspondence to Kevin L. Legge.

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Langlois, R.A., Legge, K.L. Respiratory dendritic cells: mediators of tolerance and immunity. Immunol Res 39, 128–145 (2007). https://doi.org/10.1007/s12026-007-0077-0

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