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Lung Dendritic Cells and Pulmonary Defence Mechanisms to Bacteria

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Mucosal Immunology of Acute Bacterial Pneumonia

Abstract

Dendritic cells (DCs) are potent antigen-presenting cells (APCs) that have emerged as key regulators of adaptive immunity (Immunity 31:412–424, 2009). The general function of lung DCs is to recognize and pick up foreign antigens at the outskirts of the body, and subsequently migrate with their cargo to the draining mediastinal lymph nodes where antigen is processed into immunogenic peptides and displayed onto MHCI and MHCII molecules for presentation to naïve T cells. In fact these cells should be seen as specialized cells of the mononuclear phagocyte system that have evolved from the cells of the innate immune system to control adaptive immunity that came later in evolution.

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Acknowledgements

Bart N. Lambrecht is supported by grants from FWO Flanders (Odysseus Program), European Research Council (ERC) starting grant, and Multidisciplinary Research Platform (GROUP-ID consortium) of University of Gent, Belgium. Katrijn Neyt is supported by a Fellowship of FWO Flanders. Hamida Hammad has received grants from FWO Flanders and from University of Gent.

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Authors and Affiliations

  1. Laboratory of Immunoregulation and Mucosal Immunology, Department of Molecular Biomedical Research, VIB, Ghent University, Technologiepark 927, Ghent, 9000, Belgium

    Bart N. Lambrecht, Katrijn Neyt & Hamida Hammad

  2. Department of Respiratory Medicine, University Hospital Ghent, Ghent, Belgium

    Bart N. Lambrecht, Katrijn Neyt & Hamida Hammad

  3. Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands

    Bart N. Lambrecht

  4. Department of Virology, Erasmus University Medical Center, Rotterdam, The Netherlands

    Corine H. GeurtsvanKessel

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  1. Bart N. Lambrecht
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  2. Katrijn Neyt
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  3. Corine H. GeurtsvanKessel
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  4. Hamida Hammad
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Correspondence to Bart N. Lambrecht .

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  1. Columbia University, New York, 10032, USA

    Alice Prince

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Lambrecht, B.N., Neyt, K., GeurtsvanKessel, C.H., Hammad, H. (2013). Lung Dendritic Cells and Pulmonary Defence Mechanisms to Bacteria. In: Prince, A. (eds) Mucosal Immunology of Acute Bacterial Pneumonia. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5326-0_2

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