Abstract
Neoplastic plasma cell involvement of thyroid is an uncommon condition, and it may involve thyroid in multiple myeloma or solitary plasmacytoma. Its clinical and pathological features are not well understood. We present a rare case of synchronous thyroid involvement in plasma cell leukemia presenting as thyroid nodule with primary hypothyroidism. Simultaneous cytology, immunocytochemistry, FISH analysis with 13q14.3 and TP53 on cytology smears and haematology workup were performed to diagnose and to understand disease pathobiology with poor outcome.
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References
Barton Fe, Farmer Da. (1950)Plasmacytoma of the thyroid gland. Ann surg. 132 (2):304–309.
May E, Andre MJ, (1950) Caine plasmocytome thyroidien. Ann Otolaryngol. 67(11–12):826–828.
Valentini CG, Bozzoli V, Fianchi L, Voso MT, Di Paolantonio G, Criscuolo M,Leone G, Larocca LM, Pagano L. (2011) Primary plasma cell leukemia followed by testicular plasmacytoma. Int J Hematol. 93(2):224–7.
Abbass K, Dewani S, Markert R, Kaplon MK, Baumann MA. (2011) Plasmacytoma presenting as hematuria. Int J Hematol. 93(6):825–6.
Chattopadhyay A, Nath UK, De R, Singh A, Sanyal S, Chatterjee SK, Chaudhuri U. (2008) Primary plasma cell leukemia with initial cutaneous involvement and IgA biclonal gammopathy. Ann Hematol. 87(3):249–51
Anwer S, Sternberg A. (2012) Meningeal myelomatosis. Blood. 16;120(7):1356.
Pavlovic A, Ostojic Kolonic S, Radic Kristo D, Jelic Puskaric B, Kardum Skelin I. (2015) Atypical blast morphology of primary plasma cell leukemia with renal involvement and plasmablasts in urine. Diagn Cytopathol. 43(2):158–62.
Majhi U, Murhekar K, Sundersingh S, Rajalekshmi KR. (2014) Primary plasma cell leukaemia with unusual presentations: a case series. Indian J Hematol Blood Transfus. 30(Suppl.1):390–3.
American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer, Cooper DS, Doherty GM, Haugen BR, Kloos RT, LeeSL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, Schlumberger M, Sherman SI,Steward DL, Tuttle RM. (2009) Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 19(11):1167–214. Erratum in: Thyroid. 2010 Aug. 20(8):942. Hauger, Bryan R [corrected to Haugen, Bryan R]. Thyroid. 2010 Jun; 20(6):674–5.
Bourtsos EP, Bedrossian CW, De Frias DV, Nayar R. (2000) Thyroid plasmacytoma mimicking medullary carcinoma: a potential pitfall in aspiration cytology. Diagn Cytopathol. 23(5):354–8.
Bhat V, Shariff S, Narayana Reddy RA. (2014) Extramedullary plasmacytoma of thyroid—a mimicker of medullary carcinoma at fine needle aspiration cytology: a case report. J Cytol 31:53–6
Yohan Kwon, Soo Jin Kim, Joon Ho Hur, Sung Hee Park, Sun Jin Lee, Tae Jin Lee. (2013) Solitary extramedullary plasmacytoma of thyroid in Hashimoto’s thyroiditis: mimicking benign cystic nodule on ultrasonography Journal of the Korean Society of Radiology. 69(5): 347
Sadayuki Kaba, Mitsuyoshi Hirokawa, Yuri Nobuoka, Miyoko Higuchi, Naoki Yamao, Ayana Suzuki, Nozomi Takagi, Masaru Kojima, Akira Miyauchi. (2013) Cytological findings of primary thyroid MALT lymphoma with extreme plasma cell differentiation in fine needle aspiration specimens The Journal of the Japanese Society of Clinical Cytology. 52(6): 507–517
Monisha Bhanote, Madeline F. Vazquez, Paolo Gattuso. (2009) Fine-needle aspiration biopsy of a papillary thyroid carcinoma involved by malignant plasma cell disease: A case report Diagnostic Cytopathology. 37(3): 217–219
Ozdemir E, Bayraktar M, Sökmensüer C, Kir KM, Kansu E. (2009) Late relapse of a light-chain myeloma as extramedullary plasmacytoma of the thyroid gland after second allogeneic stem-cell transplantation. Clin Transplant.23(6):981–4
Heim, S., et al. (1995) Cancer Cytogenetics 2nd ed.: 377.
Fonseca R, Blood E, Rue M, et al. (2003) Clinical and biologic implications of recurrent genomic aberrations in myeloma. Blood. 101(11):4569–75.
Jan B. Egan, Chang-Xin Shi, Waibhav Tembe, Alexis Christoforides, Ahmet Kurdoglu, Shripad Sinari, Sumit Middha, Yan Asmann, Jessica Schmidt, Esteban Braggio, Jonathan J. Keats, Rafael Fonseca, P. Leif Bergsagel, David W. Craig, John D. Carpten, A. Keith Stewart. (2012) Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides. Blood. 120(5): 1060–1066
Antonopoulou M, Silverberg A. (2013) Spurious t3 thyrotoxicosis unmasking multiple myeloma. Case Rep Endocrinol. 2013: 739302.
Bush SE, Goffinet DR, Bagshaw MA. (1981) Extramedullary plasmacytoma of the head and neck. Radiology. 140:801–5.
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Tandon, A., Paul, T.R., Singh, R. et al. Synchronous Thyroid Involvement in Plasma Cell Leukemia Masquerading as Hashimoto's Thyroiditis: Role of Ancillary Cytology Techniques in Diagnostic Workup. Endocr Pathol 26, 324–327 (2015). https://doi.org/10.1007/s12022-015-9392-5
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DOI: https://doi.org/10.1007/s12022-015-9392-5