Abstract
Plasma cell leukemia (PCL) is a highly aggressive plasma cell disease characterized by a poor prognosis and a low response rate to conventional therapy. Herein, we describe a 69-year-old patient with primary PCL, developing testicular disease while in complete hematological remission, following by muscle involvement and peritoneal dissemination.
Similar content being viewed by others
References
Kyle RA, Maldonado JE, Bayrd ED. Plasma cell leukemia. Report on 17 cases. Arch Intern Med. 1974;133:813.
International Myeloma Working Group. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol. 2003;121:749–57.
Jimenez-Zepeda VH, Dominguez-Martinez VJ. Plasma cell leukemia: a highly aggressive monoclonal gammopathy with a very poor prognosis. Int J Hematol. 2009;89:259–68.
Costello R, Sainty D, Bouabdallah R, Fermand JP, Delmer A, Diviné M, et al. Primary plasma cell leukemia: a report of 18 cases. Leuk Res. 2001;25(2):103–7.
Noel P, Kyle RA. Plasma cell leukemia: an evaluation of response to therapy. Am J Med. 1987;83(6):1062–8.
De Rose AF, Giglio M, Naselli A, Truini M, Carmignani G. Case report: testicular secondary localization of a multiple myeloma. Int Urol Nephrol. 2002;33(1):101–2.
Alvarez-Múgica M, Jalón Monzón A, Bulnes Vázquez V, Aguilar Andrea C, Fernández Gómez JM, González Alvarez RC, et al. Secondary testicular plasmocytoma. Arch Esp Urol. 2007;60(1):99–102.
Turhal N, Henehan MD, Kaplan KL. Multiple myeloma: a patient with unusual features including intracranial and meningeal involvement, testicular involvement, organomegaly, and plasma cell leukemia. Am J Hematol. 1998;57(1):51–6.
Alexandrescu DT, Koulova L, Wiernik PH. Unusual cutaneous involvement during plasma cell leukaemia phase in a multiple myeloma patient after treatment with thalidomide: a case report and review of the literature. Clin Exp Dermatol. 2005;30(4):391–4.
Lewinski UH, Klein B, Gafter U, Djaldetti M. Acute plasma cell leukaemia followed by extramedullary plasmacytoma. Scand J Haematol. 1980;24(2):131–6.
Pellat-Deceunynck C, Barillé S, Jego G, Puthier D, Robillard N, Pineau D, et al. The absence of CD56 (NCAM) on malignant plasma cells is a hallmark of plasma cell leukemia and a special subset of multiple myeloma. Leukemia. 1998;12:1977–82.
Walker JD, Kaczmarski RS. Survival of twenty-two months in a patient with primary plasma cell leukaemia treated with melphalan and prednisolone. Postgrad Med J. 1988;64(749):232–5.
Wellwood J, Taylor K, Wright S, Bentley M, Hill G, Phan H, et al. Relapsed plasma cell leukaemia presenting with aggressive extramedullary plasmacytomas in the meninges and testis—a missed opportunity for induction CNS prophylaxis. Leuk Lymphoma. 2002;43(4):893–6.
Finnegan DP, Kettle P, Drake M, Matthews C, Alexander HD, Popat R, et al. Bortezomib is effective in primary plasma cell leukemia. Leuk Lymphoma. 2006;47(8):1670–3.
Capalbo S, Chiefa A, Delia M, Diomede D, Liso V. Effective combination therapy of bortezomib and dexamethasone for a plasma cell leukemia patient with multiple osteolytic lesions and extramedullary involvement. Acta Oncol. 2007;46:262–4.
Al-Nawakil C, Tamburini J, Bardet V, Chapuis N, Bourry E, Roux C, et al. Bortezomib, doxorubicin and dexamethasone association is an effective option for plasma cell leukemia induction therapy. Leuk Lymphoma. 2008;49(10):2012–4.
Musto P, Rossini F, Gay F, Pitini V, Guglielmelli T, D’Arena G, et al. Efficacy and safety of bortezomib in patients with plasma cell leukemia. Cancer. 2007;109(11):2285–90.
Singh AV, Palladino MA, Lloyd GK, Potts BC, Chauhan D, Anderson KC. Pharmacodynamic and efficacy studies of the novel proteasome inhibitor NPI-0052 (marizomib) in a human plasmacytoma xenograft murine model. Br J Haematol. 2010;149(4):550–9.
Bouchard PR, Juedes MJ, Nix D, Read M. Nonclinical discovery and development of bortezomib (PS-341, VELCADER), a proteasome Inhibitor for the treatment of cancer (13-Nov-2004). In: 55th Annual Meeting of the American College of Veterinary Pathologists (ACVP) and 39th Annual Meeting of the American Society of Clinical Pathology (ASVCP), ACVP and ASVCP, editors. 2004.
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Valentini, C.G., Bozzoli, V., Fianchi, L. et al. Primary plasma cell leukemia followed by testicular plasmacytoma. Int J Hematol 93, 224–227 (2011). https://doi.org/10.1007/s12185-010-0745-z
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12185-010-0745-z