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Serum periostin is a potential biomarker for non-alcoholic fatty liver disease: a case–control study

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Abstract

Recent animal studies support close associations of Periostin with hepatosteatosis and steatohepatitis. This study is to evaluate the role of serum periostin in non-alcoholic fatty liver disease (NAFLD). A hospital-based age-/sex-matched case–control study was conducted. Binary logistic regression and receiver operating characteristic (ROC) curve were performed. Serum adipokines were measured by Adipokine Magnetic Bead Panel kits. The serum concentration of Periostin in NAFLD (1914.16 [1323.59–2654.88] ng/ml, P < 0.001) was higher than it in control (1244.94 [837.87—2028.55] ng/ml). The frequency of NAFLD grew (29.8, 52.6, and 67.2 %, P < 0.001), as Periostin concentration increased among its tertiles. Compared with the 1st tertile, the 2nd and the 3rd tertiles of Periostin indicated significant associations with higher odds of NAFLD [adjusted odds ratio = 2.602 (95 % confidence interval (CI) 1.030–6.575), P = 0.043 and 2.819 (95 % CI 1.629–4.878), P < 0.001]. ROC curve of Periostin was developed to predict the presence of NAFLD (area under ROC = 0.693 [95 % CI 0.614–0.771], P < 0.001). Lastly, Periostin correlated with several adipokines, including Resistin (r = 0.269, P = 0.018), Adiponectin (r = −0.352, P = 0.002), Interleukin (IL)-6 (r = 0.359, P = 0.001), IL-8 (r = 0.364, P = 0.001), Lipocalin-2 (r = 0.623, P < 0.001), Hepatocyte growth factor (r = 0.522, P < 0.001), and Nerve growth factor (r = 0.239, P = 0.036). It suggests Periostin as a potential biomarker in the management of NAFLD.

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Acknowledgments

This work was supported by the National Key Basic Research Development Program (No. 2012CB524905), National Science and Technology Support Plan Project (No. 2012BAI06B04), and National Natural Science Foundation of China (Nos. 81170378 and 81230012).

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    1. Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China

      Jin-Zhou Zhu, Hua-Tuo Zhu, Yi-Ning Dai, Chun-Xiao Li, Zhi-Yun Fang, Xing-Yong Wan, Yu-Ming Wang, Chao-Hui Yu & You-Ming Li

    2. Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China

      De-Jian Zhao

    3. Department of Surgery, Suqian People’s Hospital, Suqian, 223800, Jiangsu, China

      Fang Wang

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    Jin-Zhou Zhu and Hua-Tuo Zhu have contributed equally to this work.

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    Zhu, JZ., Zhu, HT., Dai, YN. et al. Serum periostin is a potential biomarker for non-alcoholic fatty liver disease: a case–control study. Endocrine 51, 91–100 (2016). https://doi.org/10.1007/s12020-015-0735-2

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