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Additive effect of heavy metals on metabolic syndrome in the Korean population: the Korea National Health and Nutrition Examination Survey (KNHANES) 2009–2010

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Abstract

There have been increasing concerns regarding health problems due to endocrine disrupting chemicals (EDCs). We investigated association of heavy metals, including lead, mercury, and cadmium, with metabolic syndrome (MS) and its individual components in the Korean population. Participants included 1,961 males and 1,989 females 20 years of age or older from the fourth and fifth Korea National Health and Nutritional Examination Surveys of the Korean population (2009 and 2010). We examined the relationship of blood lead, mercury, and cadmium levels with MS and the additive effect of three heavy metals on MS after adjustment for age, sex, body mass index (BMI), region, smoking, alcohol consumption, and regular exercise. Blood concentration of lead showed a significant but modest association with prevalence of MS (P = 0.04). Other heavy metals did not show such a relationship with MS. When the participants were classified according to the sum of category numbers of the three heavy metals, adjusted odds ratios were 1.0, 1.355, 1.638, and 1.556 (P < 0.01). Among components of MS, significant relationship of the sum of heavy metals with hypertension and elevated triglyceride was demonstrated. Blood concentration of lead was positively associated with the prevalence of MS. Of particular interest, cumulative effect of a mixture of lead, mercury, and cadmium on prevalence of MS was stronger than the sum of effect of each heavy metal. Accumulative effect of exposure to heavy metals could be more additive or synergistic than individual exposure in the general population.

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Acknowledgments

This research was supported by a grant from the Daegu and Kyungpook local committee of the Korean Diabetes Association and by the Dongguk University research fund.

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Authors and Affiliations

  1. Department of Internal Medicine, Dongguk University College of Medicine, Dongdae-ro 87, Gyeongju, Gyeongbuk Province, 780-350, South Korea

    Seong-Su Moon

  2. Medical Institute of Dongguk University, Gyeongju, South Korea

    Seong-Su Moon

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Correspondence to Seong-Su Moon.

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Moon, SS. Additive effect of heavy metals on metabolic syndrome in the Korean population: the Korea National Health and Nutrition Examination Survey (KNHANES) 2009–2010. Endocrine 46, 263–271 (2014). https://doi.org/10.1007/s12020-013-0061-5

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  • DOI: https://doi.org/10.1007/s12020-013-0061-5

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