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The Distraction Osteogenesis Callus: a Review of the Literature

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Abstract

The distraction osteogenesis has been an integrated treatment approach in significant bone deficiencies resulting from debridement or high-energy trauma. Nevertheless, it usually demands a prolonged treatment period attributed to the more profound distraction osteogenesis callus physiology. This distraction callus is a tissue not naturally present in mammals and results after surgical intervention. Despite sharing quite similar molecular and biomechanical mechanisms to the fracture-healing callus, it recruits unique physiological pathways. This review presents the deep physiology of the distraction osteogenesis callus, the familiar pathways with the fracture healing callus, and current maturation’s acceleration tactic concepts.

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  1. 3rd Orthopaedic Department, KAT Hospital, University of Athens, Athens, Greece

    Meletis Rozis, Vasileios Polyzois & Spyros Pneumaticos

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  1. Meletis Rozis
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Rozis, M., Polyzois, V. & Pneumaticos, S. The Distraction Osteogenesis Callus: a Review of the Literature. Clinic Rev Bone Miner Metab 19, 24–35 (2021). https://doi.org/10.1007/s12018-021-09282-x

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