Abstract
Stroke is the second foremost cause of mortality worldwide and a major cause of long-term disability. Due to changes in lifestyle and an aging population, the incidence of stroke continues to increase and stroke mortality predicted to exceed 12 % by the year 2030. However, the development of pharmacological treatments for stroke has failed to progress much in over 20 years since the introduction of the thrombolytic drug, recombinant tissue plasminogen activator. These alarming circumstances caused many research groups to search for alternative treatments in the form of neuroprotectants. Here, we consider the potential use of phytochemicals in the treatment of stroke. Their historical use in traditional medicine and their excellent safety profile make phytochemicals attractive for the development of therapeutics in human diseases. Emerging findings suggest that some phytochemicals have the ability to target multiple pathophysiological processes involved in stroke including oxidative stress, inflammation and apoptotic cell death. Furthermore, epidemiological studies suggest that the consumption of plant sources rich in phytochemicals may reduce stroke risk, and so reinforce the possibility of developing preventative or neuroprotectant therapies for stroke. In this review, we describe results of preclinical studies that demonstrate beneficial effects of phytochemicals in experimental models relevant to stroke pathogenesis, and we consider their possible mechanisms of action.
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Acknowledgments
This work was supported NUHS Seed Fund for Basic Science Research (R-185-000-255-112), Singapore Ministry of Education Tier 1 grant (R-185-000-285-112), the start-up fund provided by the National University of Singapore, and in part, by the Intramural Research Program of the National Institute on Aging, NIH.
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Joonki Kim and David Yang-Wei Fann have contributed equally to this manuscript.
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Kim, J., Fann, D.YW., Seet, R.C.S. et al. Phytochemicals in Ischemic Stroke. Neuromol Med 18, 283–305 (2016). https://doi.org/10.1007/s12017-016-8403-0
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DOI: https://doi.org/10.1007/s12017-016-8403-0