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Translin-Associated Factor X Gene (TSNAX) may be Associated with Female major Depressive Disorder in the Japanese Population

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Abstract

Several investigations have reported that the translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) was associated with major psychiatric disorders including schizophrenia, bipolar disorder (BP), and major depressive disorder (MDD). TSNAX is located immediately upstream of DISC1, and has been shown to undergo intergenic splicing with DISC1. It thus may also be influenced by translocation. To our knowledge, there are no reported gene-based association analyses between TSNAX and mood disorders in the Japanese population. We conducted a case–control study of Japanese samples (158 bipolar patients, 314 major depressive disorder patients, and 811 controls) with three tagging SNPs in TSNAX, selected using HapMap database. In addition, we performed an association analysis between TSNAX and the efficacy of fluvoxamine treatment in 120 Japanese patients with MDD. The MDD patients in this study had scores of 12 or higher on the 17 items of the Structured Interview Guide for Hamilton Rating Scale for Depression (SIGH-D). We defined a clinical response as a decrease of more than 50% in baseline SIGH-D within 8 weeks, and clinical remission as an SIGH-D score of less than 7 at 8 weeks. We found an association between rs766288 in TSNAX and female MDD in the allele/genotype analysis. However, we did not find any association between TSNAX and BP or the fluvoxamine therapeutic response in MDD in the allele/genotype analysis or haplotype analysis. Our results suggest that rs766288 in TSNAX may play a role in the pathophysiology of female MDD in the Japanese population. A replication study using larger samples may be required for conclusive results, since our sample size was small.

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Acknowledgments

We thank Ms M Miyata and Ms S Ishihara for their technical support. This work was supported in part by research grants from the Ministry of Education, Culture, Sports, Science and Technology, the Ministry of Health, Labor and Welfare, and the Japan Health Sciences Foundation (Research on Health Sciences focusing on Drug Innovation).

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Authors and Affiliations

  1. Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, 470-1192, Japan

    Akiko Okuda, Taro Kishi, Tomo Okochi, Masashi Ikeda, Tsuyoshi Kitajima, Tomoko Tsunoka, Takenori Okumukura, Yasuhisa Fukuo, Yoko Kinoshita, Kunihiro Kawashima, Yoshio Yamanouchi & Nakao Iwata

  2. Okehazama Hospital, Toyoake, Aichi, 470-1168, Japan

    Akiko Okuda

  3. Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK

    Masashi Ikeda

  4. Neuropsychiatric Research Institute, Seiwa Hospital, Tokyo, 162-0851, Japan

    Toshiya Inada

  5. Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, 466-8850, Japan

    Norio Ozaki

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  1. Akiko Okuda
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  2. Taro Kishi
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  3. Tomo Okochi
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  4. Masashi Ikeda
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  5. Tsuyoshi Kitajima
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  9. Yoko Kinoshita
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  10. Kunihiro Kawashima
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  12. Toshiya Inada
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  13. Norio Ozaki
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  14. Nakao Iwata
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Corresponding author

Correspondence to Taro Kishi.

Additional information

Akiko Okuda, Taro Kishi participated equally in this work.

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Okuda, A., Kishi, T., Okochi, T. et al. Translin-Associated Factor X Gene (TSNAX) may be Associated with Female major Depressive Disorder in the Japanese Population. Neuromol Med 12, 78–85 (2010). https://doi.org/10.1007/s12017-009-8090-1

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  • DOI: https://doi.org/10.1007/s12017-009-8090-1

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