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Association study of clock gene (CLOCK) and schizophrenia and mood disorders in the Japanese population

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Abstract

Recently the clock genes have been reported to play some roles in neural transmitter systems, including the dopamine system, as well as to regulate circadian rhythms. Abnormalities in both of these mechanisms are thought to be involved in the pathophysiology of major mental illness such as schizophrenia and mood disorders including bipolar disorder (BP) and major depressive disorder (MDD). Recent genetic studies have reported that CLOCK, one of the clock genes, is associated with these psychiatric disorders. Therefore, we investigated the association between the six tagging SNPs in CLOCK and the risk of these psychiatric disorders in Japanese patients diagnosed with schizophrenia (733 patients), BP (149) and MDD (324), plus 795 Japanese controls. Only one association, with schizophrenia in females, was detected in the haplotype analysis (P = 0.0362). However, this significance did not remain after Bonferroni correction (P = 0.0724). No significant association was found with BP and MDD. In conclusion, we suggest that CLOCK may not play a major role in the pathophysiology of Japanese schizophrenia, BP and MDD patients. However, it will be important to replicate and confirm these findings in other independent studies using large samples.

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Acknowledgments

We thank Ms. M. Miyata and Ms. S. Ishihara for their technical support. This work was supported in part by research grants from the Japan Ministry of Education, Culture, Sports, Science and Technology, the Ministry of Health, Labor and Welfare, and the Health Sciences Foundation (Research on Health Sciences focusing on Drug Innovation).

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Authors and Affiliations

  1. Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, 470-1192, Japan

    Taro Kishi, Tsuyoshi Kitajima, Masashi Ikeda, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Tomo Okochi, Takenori Okumura, Tomoko Tsunoka & Nakao Iwata

  2. Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, 466-8850, Japan

    Norio Ozaki

  3. Neuropsychiatric Research Institute, Seiwa Hospital, Tokyo, 162-0851, Japan

    Toshiya Inada

  4. Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK

    Masashi Ikeda

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  1. Taro Kishi
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Correspondence to Taro Kishi.

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T. Kishi and T. Kitajima have contributed equally to this work.

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Kishi, T., Kitajima, T., Ikeda, M. et al. Association study of clock gene (CLOCK) and schizophrenia and mood disorders in the Japanese population. Eur Arch Psychiatry Clin Neurosci 259, 293–297 (2009). https://doi.org/10.1007/s00406-009-0869-4

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  • DOI: https://doi.org/10.1007/s00406-009-0869-4

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