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Effect of Selenium and Zinc Supplementation on Reproductive Organs Following Postnatal Protein Malnutrition

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Abstract

Protein diets are required for the normal development of the reproductive system and their inadequacy or deficiency might have hazardous functional complications during maturational and developmental stages. The study was carried out to evaluate the effect of selenium (Se) and zinc (Zn) supplementation on the male and female reproductive organs of rats with postnatal protein malnutrition. Male and female weanling rats were randomly assigned to six groups respectively. The adequate protein diet rats were fed with 16% casein diet while the protein malnourished diet (PMD) rats were fed with 5% casein diet. After the 8th week of feeding, Se (sodium selenite; Na2SeO3) and Zn (zinc sulfate; ZnSO4·7H2O) were supplemented for 3 weeks. The growth curve of body weights, lipid profile, testosterone and progesterone level, Na+-K+-ATPase activity, oxidative stress, and antioxidant status were evaluated. The results showed that PMD reduced the body weights of male and female rats. It also reduced the activities of catalase and glutathione peroxidase in the testes, but reductions in superoxide dismutase and glutathione-S-transferase activities, glutathione, vitamins C and E, testosterone, and progesterone levels were observed in both the testes and ovaries. Furthermore, PMD increased the nitric oxide level in both organs and altered the plasma lipid profiles in both sexes. Se and Zn supplementation, however, restored almost all the alterations observed in all the parameters analyzed. In conclusion, Se and Zn supplementation protects the male and female reproductive organs of rats against postnatal protein malnutrition.

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Data Availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

The authors appreciate the efforts of Mr. S.O. Adenekan for the technical assistance. We also thank the anonymous reviewers for their thoroughness and constructive criticisms.

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  1. Adedayo Adedeji Obadimu and Olusegun Lateef Adebayo contributed equally.

Authors and Affiliations

  1. Department of Biochemistry, Faculty of Basic Medical Sciences, Obafemi Awolowo College of Health Sciences, Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria

    Adedayo Adedeji Obadimu, Bamidele Sanya Fagbohunka & Gbenga Adebola Adenuga

  2. Department of Biochemistry, Faculty of Basic Medical Sciences, Redeemer’s University, Ede, Osun State, P.M.B. 230, Nigeria

    Olusegun Lateef Adebayo

  3. Department of Food Technology,, Federal Institute of Industrial Research Oshodi (FIIRO), Lagos, Lagos State, Nigeria

    Adesewa Omolara Tugbobo-Amisu

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Contributions

Olusegun Lateef Adebayo and Gbenga Adebola Adenuga contributed to the study conception and design. Also, the first draft of the manuscript was written by Olusegun Lateef Adebayo and all authors commented on previous versions of the manuscript. Adedayo Adedeji Obadimu carried out the major laboratory work and Adesewa Omolara Tugbobo-Amisu joined in data collection. Bamidele Sanya Fagbohunka joined in the supervision of the work. All authors read and approved the final manuscript.

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Correspondence to Olusegun Lateef Adebayo.

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This study was performed in line with the NIH Guidelines for Humane Use and Care of Laboratory Animals. Approval was granted by the Ethics Committee of Olabisi Onabanjo University, Ogun State, Nigeria.

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Obadimu, A.A., Adebayo, O.L., Tugbobo-Amisu, A.O. et al. Effect of Selenium and Zinc Supplementation on Reproductive Organs Following Postnatal Protein Malnutrition. Biol Trace Elem Res 202, 1126–1139 (2024). https://doi.org/10.1007/s12011-023-03751-8

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  • DOI: https://doi.org/10.1007/s12011-023-03751-8

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