Abstract
Metals are considered major public health hazards, and they are known to accumulate in fruits, which are consumed by humans because of their unique sweet taste and potential health benefits. Therefore, the aims of this study were to determine the concentration of ten metals, namely arsenic (As), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), iron (Fe), manganese (Mn), nickel (Ni), lead (Pb), and zinc (Zn) in red grape samples grown in Gonabad vineyards and to estimate the associated health risks of metals in terms of chronic daily intake (CDI), carcinogenic and non-carcinogenic risks by hazard quotient (HQ), hazard index (HI), and cancer risk (CR) for children, teenagers, and adults. The overall concentrations of the metals in red grapes were in the range 0.07–0.5 (mean 0.14), 0.08–0.13 (mean 0.10), 0.07–0.13 (mean 0.09), 0.06–1.49 (mean 0.29), 0.52–4.12 (mean 1.65), 6.43–42.17 (mean 19.01), 0.89–4.04 (mean 1.89), 0.07–9.23 (mean 0.71), 0.07–0.37 (mean 0.18), and 0.40–4.13 (mean 1.05) mg/kg dry weight for As, Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb, and Zn, respectively. Based on the results, As in 11.76% and Zn in 5.88% of the samples exceeded the FAO/WHO permissible limits. The estimated non-carcinogenic and carcinogenic risk indices for children, teenagers, and adults showed that the results were lower than the critical value (1) and were in acceptable range. Therefore, red grape is safe for consumption with no impact on the human health. However, red grape consumption was just one part of fruit consumption, and the potential health hazards for inhabitants might actually be higher than in this research when other routes of heavy metal intake and also other fruits are considered.
Similar content being viewed by others
References
Zahir E, Naqvi II, Uddin SM (2009) Market basket survey of selected metals in fruits from Karachi city (Pakistan). J Basic Appl Sci 5:47–52
Amer MM, Sabry BA, Marrez DA, Hathout AS, Fouzy AS (2019) Exposure assessment of heavy metal residues in some Egyptian fruits. Toxicol Rep 6:538–543
Unaegbu M, Engwa GA, Abaa QD, Aliozo SO, Ayuk EL, Osuji GA, Onwurah EI (2016) Heavy metal, nutrient and antioxidant status of selected fruit samples sold in Enugu, Nigeria. Int J Food Contam 3:1–8
Shaheen N, Irfan NM, Khan IN, Islam S, Islam MS, Ahmed MK (2016) Presence of heavy metals in fruits and vegetables: health risk implications in Bangladesh. Chemosphere 152:431–438
Bagdatlioglu N, Nergiz C, Ergonul PG (2010) Heavy metal levels in leafy vegetables and some selected fruits. J für Verbraucherschutz und Lebensmittelsicherheit 5:421–428
Yang M, Luo F, Zhang X, Zhou L, Lou Z, Zhao M, Chen Z (2019) Dissipation and risk assessment of multiresidual fungicides in grapes under field conditions. J Agric Food Chem 68:1071–1078
Li X, Dong S, Su X (2018) Copper and other heavy metals in grapes: a pilot study tracing influential factors and evaluating potential risks in China. Sci Rep 8:1–10
Chaignon V, Sanchez-Neira I, Herrmann P, Jaillard B, Hinsinger P (2003) Copper bioavailability and extractability as related to chemical properties of contaminated soils from a vine-growing area. Environ Pollut 123:229–238
Mirzaei M, Marofi S, Solgi E, Abbasi M, Karimi R, RiyahiBakhtyari HR (2020) Ecological and health risks of soil and grape heavy metals in long-term fertilized vineyards (Chaharmahal and Bakhtiari province of Iran). Environ Geochem Health 42:27–43
D’Mello J (2003) Mycotoxins in cereal grains, nuts and other plant products. Food Saf Contam Toxicol 4:65–90
Yang L, Ren Q, Ge S, Jiao Z, Zhan W, Hou R, Ruan X, Pan Y, Wang Y (2022) Metal(loid)s spatial distribution, accumulation, and potential health risk assessment in soil-wheat systems near a Pb/Zn smelter in Henan Province, Central China. Int J Environ Res Public Health 19:2527
Płotka-Wasylka J, Rutkowska M, Cieślik B, Tyburcy A, Namieśnik J (2017) Determination of selected metals in fruit wines by spectroscopic techniques. J Anal Methods Chem 2017
Ibrahim D, Froberg B, Wolf A, Rusyniak DE (2006) Heavy metal poisoning: clinical presentations and pathophysiology. Clin Lab Med 26:67–97
Allah A, Gharaibeh A, Radaydeh S, Al-Momani I (2018) Assessment of toxic and essential heavy metals in imported dried fruits sold in the local markets of Jordan. Eur J Chem 9:394–399
Hu B, Jia X, Hu J, Xu D, Xia F, Li Y (2017) Assessment of heavy metal pollution and health risks in the soil-plant-human system in the Yangtze River Delta, China. Int J Environ Res Public Health 14:1042
Dhar PK, Uddin MN, Ara MH, Tonu NT (2019) Heavy metal concentration in vegetables, fruits and cereals and associated health risk of human in Khulna, Bangladesh. J Water Environ Sci 3:453–459
Filipović-Trajković R, Ilić ZS, Šunić L, Andjelković S (2012) The potential of different plant species for heavy metals accumulation and distribution. J Food Agric Environ 10:959–964
Hoaghia M-A, Cadar O, Moisa C, Roman C, Kovacs E (2022) Heavy metals and health risk assessment in vegetables grown in the vicinity of a former non-metallic facility located in Romania. Environ Sci Pollut Res 29:40079–40093
Vystavna Y, Rushenko L, Diadin D, Klymenko O, Klymenko M (2014) Trace metals in wine and vineyard environment in southern Ukraine. Food Chem 146:339–344
Oyareme V, Akpogheneta SE, Iloba B, Ogidiagba F (2020) Occurrence and concentration of heavy metals in garden egg, tomatoes, cucumber and watermelon from two major markets in Edo State, Nigeria. Food Public Health 10:63–67
Cooper AM, Felix D, Alcantara F, Zaslavsky I, Work A, Watson PL, Pezzoli K, Yu Q, Zhu D, Scavo AJ (2020) Monitoring and mitigation of toxic heavy metals and arsenic accumulation in food crops: a case study of an urban community garden. Plant Direct 4:e00198
Chabukdhara M, Munjal A, Nema AK, Gupta SK, Kaushal RK (2016) Heavy metal contamination in vegetables grown around peri-urban and urban-industrial clusters in Ghaziabad, India. Hum Ecol Risk Assess 22:736–752
Saha S, Hazra G, Saha B, Mandal B (2015) Assessment of heavy metals contamination in different crops grown in long-term sewage-irrigated areas of Kolkata, West Bengal, India. Environ Monit Assess 187:1–12
Rai PK, Lee SS, Zhang M, Tsang YF, Kim K-H (2019) Heavy metals in food crops: health risks, fate, mechanisms, and management. Environ Int 125:365–385
Seifi M, Mahvi AH, Hashemi SY, Arfaeinia H, Pasalari H, Zarei A, Changani F (2019) Spatial distribution, enrichment and geo-accumulation of heavy metals in surface sediments near urban and industrial areas in the Persian Gulf. Desal Water Treat 158:130–139
Sadeghi H, Fazlzadeh M, Zarei A, Mahvi AH, Nazmara S (2022) Spatial distribution and contamination of heavy metals in surface water, groundwater and topsoil surrounding Moghan’s tannery site in Ardabil, Iran. Int J Environ Anal Chem 102:1049–1059
Abdul KSM, Jayasinghe SS, Chandana EP, Jayasumana C, De Silva PMC (2015) Arsenic and human health effects: a review. Environ Toxicol Pharmacol 40:828–846
Çelik U, Oehlenschläger J (2007) High contents of cadmium, lead, zinc and copper in popular fishery products sold in Turkish supermarkets. Food Control 18:258–261
Ara MH, Khan AR, Uddin N, Dhar PK (2018) Health risk assessment of heavy metals in the leafy, fruit, and root vegetables cultivated near Mongla industrial area, Bangladesh. J Hum Environ Health Promot 4:144–152
Sherief LM, Abdelkhalek ER, Gharieb AF, Sherbiny HS, Usef DM, Almalky MA, Kamal NM, Salama MA, Gohar W (2015) Cadmium status among pediatric cancer patients in Egypt. Medicine 94
Radwan MA, Salama AK (2006) Market basket survey for some heavy metals in Egyptian fruits and vegetables. Food Chem Toxicol 44:1273–1278
Mahdavi V, Eslami Z, Molaee-Aghaee E, Peivasteh-Roudsari L, Sadighara P, Fakhri Y, Ravanlou AA (2022) Evaluation of pesticide residues and risk assessment in apple and grape from western Azerbaijan Province of Iran. Environ Res 203:111882
Rezaei H, Jafari A, Kamarehie B, Fakhri Y, Ghaderpoury A, Karami MA, Ghaderpoori M, Shams M, Bidarpoor F, Salimi M (2019) Health-risk assessment related to the fluoride, nitrate, and nitrite in the drinking water in the Sanandaj, Kurdistan County. Iran Hum Ecol Risk Assess Int J 25:1242–1250
USEPA, Regional screening levels (RSLs)-generic tables. Available at: USA: United States environmental protection agency. https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables
Wang J, Zhang X, Ling W, Liu R, Liu J, Kang F, Gao Y (2017) Contamination and health risk assessment of PAHs in soils and crops in industrial areas of the Yangtze River Delta region, China. Chemosphere 168:976–987
Baki MA, Hossain MM, Akter J, Quraishi SB, Shojib MFH, Ullah AA, Khan MF (2018) Concentration of heavy metals in seafood (fishes, shrimp, lobster and crabs) and human health assessment in Saint Martin Island, Bangladesh. Ecotoxicol Environ Saf 159:153–163
Mondal D, Polya DA (2008) Rice is a major exposure route for arsenic in Chakdaha block, Nadia district, West Bengal, India: a probabilistic risk assessment. Appl Geochem 23:2987–2998
Esmaili-sari A, Shaabani Z, Moradi AM, Taghavi L, Farsad F (2021) Possible health assessment for heavy metal concentration in water, sediment, and fish species and pregnant women’s biomonitoring in Miankaleh Peninsula, Iran. Environ Sci Pollut Res Int 29:37187–37203
Li Z, Ma Z, van der Kuijp TJ, Yuan Z, Huang L (2014) A review of soil heavy metal pollution from mines in China: pollution and health risk assessment. Sci Total Environ 468:843–853
Rostami R, Zarei A, Saranjam B, Ghaffari HR, Hazrati S, Poureshg Y, Fazlzadeh M (2019) Exposure and risk assessment of PAHs in indoor air of waterpipe cafés in Ardebil, Iran. Building Environ 155:47–57
Qing X, Yutong Z, Shenggao L (2015) Assessment of heavy metal pollution and human health risk in urban soils of steel industrial city (Anshan), Liaoning, Northeast China. Ecotoxicol Environ Saf 120:377–385
Zhang T, Zhang Y, Li W, Wang L, Jiao Y, Wang Y, Jiang D, Gao X (2021) Occurrence and dietary exposure of heavy metals in marketed vegetables and fruits of Shandong Province, China. Food Sci Nutrit 9:5166–5173
Kasozi KI, Hamira Y, Zirintunda G, Alsharif KF, Altalbawy FM, Ekou J, Tamale A, Matama K, Ssempijja F, Muyinda R (2021) Descriptive analysis of heavy metals content of beef from eastern Uganda and their safety for public consumption. Front Nutr 8:592340
Gupta N, Khan D, Santra S (2012) Heavy metal accumulation in vegetables grown in a long-term wastewater-irrigated agricultural land of tropical India. Environ Monit Assess 184:6673–6682
Adedokun AH, Njoku KL, Akinola MO, Adesuyi AA, Jolaoso AO (2016) Potential human health risk assessment of heavy metals intake via consumption of some leafy vegetables obtained from four market in Lagos Metropolis, Nigeria. J Appl Sci Environ Manage 20:530–539
Babuskin S, Yessuf AM, Hameed OB (2020) Monitoring and assessment of the potential health risks associated with the toxic heavy metals content in selected fruits grown in Arba Minch region of Ethiopia. Int J Environ Anal Chem 1–12
Odukoya A, Olobaniyi S, Abdussalam M (2016) Metal pollution and health risk assessment of soil within an urban industrial estate, southwest Nigeria. Ife J Sci 18:573–583
Qasemi M, Afsharnia M, Farhang M, Ghaderpoori M, Karimi A, Abbasi H, Zarei A (2019) Spatial distribution of fluoride and nitrate in groundwater and its associated human health risk assessment in residents living in Western Khorasan Razavi. Iran Desalin Water Treat 170:176–186
Sajjadi SA, Mohammadi A, Khosravi R, Zarei A (2022) Distribution, exposure, and human health risk analysis of heavy metals in drinking groundwater of Ghayen County, Iran. Geocarto Int 1–16
Kamarehie B, Jafari A, Zarei A, Fakhri Y, Ghaderpoori M, Alinejad A (2019) Non-carcinogenic health risk assessment of nitrate in bottled drinking waters sold in Iranian markets: a Monte Carlo simulation. Accreditation Qual Assur 24:417–426
Gnonsoro UP, Ake Assi YED, Sangare NS, Kouakou YU, Trokourey A (2022) Health risk assessment of heavy metals (Pb, Cd, Hg) in hydroalcoholic gels of Abidjan, Côte d’Ivoire. Biol Trace Elem Res 200:2510–2518
Yi Y, Yang Z, Zhang S (2011) Ecological risk assessment of heavy metals in sediment and human health risk assessment of heavy metals in fishes in the middle and lower reaches of the Yangtze River basin. Environ Pollut 159:2575–2585
Kamunda C, Mathuthu M, Madhuku M (2016) Health risk assessment of heavy metals in soils from Witwatersrand Gold Mining Basin, South Africa. Int J Environ Res Public Health 13:663
Gabarrón M, Faz A, Acosta J (2017) Soil or dust for health risk assessment studies in urban environment. Arch Environ Contam Toxicol 73:442–455
FAO/WHO Joint FAO/WHO Food Standards Programme Codex Committee on contaminants in foods. Food. CF/5INF/1. pp 1–89. (2011)
Esposito M, De Roma A, Cavallo S, Miedico O, Chiaravalle E, Soprano V, Baldi L, Gallo P (2019) Trace elements in vegetables and fruits cultivated in Southern Italy. J Food Compost Anal 84:103302
Orescanin V, Katunar A, Kutle A, Valkovic V (2008) Heavy metals in soil, grape, and wine. J Trace Microprobe Tech 21:1–9
Bayo D, Adeniyi O, Adeniyi A, Ariwoola O (2021) Heavy metal concentration and health risk assessment of selected fruits sold in Jos Metropolis. Adv Chem Res 3:1–1
Kumar P, Shamim RMD, Nazim Uddin MD, Rashid M (2019) Betel quid chewing: a possible source of heavy metal exposure to the people in Khulna, Bangladesh. J Mater Environ Sci 10(7):637–646
Ferraro PM, Bonello M, Frigo AC, D’Addessi A, Sturniolo A, Gambaro G (2011) Cadmium exposure and kidney stone formation in the general population—an analysis of the National Health and Nutrition Examination Survey III data. J Endourol 25:875–880
Kazantzis G (2004) Cadmium, osteoporosis and calcium metabolism. Biometals 17:493–498
Dessie BK, Gari SR, Mihret A, Desta AF, Mehari B (2021) Determination and health risk assessment of trace elements in the tap water of two sub-cities of Addis Ababa, Ethiopia. Heliyon 7:e06988
O’Neal SL, Hong L, Fu S, Jiang W, Jones A, Nie LH, Zheng W (2014) Manganese accumulation in bone following chronic exposure in rats: steady-state concentration and half-life in bone. Toxicol Lett 229:93–100
Zhu F-M, Du B, Li F-Y, Zhang J-C, Li J (2012) Measurement and analysis of mineral and heavy metal components in grape cultivars by inductively coupled plasma-optical emission spectrometer (ICP-OES). J Verbr Lebensm 7:137–140
Zheng N, Wang Q, Zhang X, Zheng D, Zhang Z, Zhang S (2007) Population health risk due to dietary intake of heavy metals in the industrial area of Huludao city, China. Sci Total Environ 387:96–104
Chen C, Qian Y, Chen Q, Li C (2011) Assessment of daily intake of toxic elements due to consumption of vegetables, fruits, meat, and seafood by inhabitants of Xiamen, China. J Food Sci 76:T181–T188
Skordas K, Papastergios G, Filippidis A (2013) Major and trace element contents in apples from a cultivated area of central Greece. Environ Monit Assess 185:8465–8471
Roba C, Roşu C, Piştea I, Ozunu A, Baciu C (2016) Heavy metal content in vegetables and fruits cultivated in Baia Mare mining area (Romania) and health risk assessment. Environ Sci Pollut Res 23:6062–6073
Alagić SČ, Tošić SB, Dimitrijević MD, Antonijević MM, Nujkić MM (2015) Assessment of the quality of polluted areas based on the content of heavy metals in different organs of the grapevine (Vitis vinifera) cv Tamjanika. Environ Sci Pollut Res 22:7155–7175
Al Nasir FM, Jiries AG, Batarseh MI, Beese F (2001) Pesticides and trace metals residue in grape and home made wine in Jordan. Environ Monit Assess 66:253–263
Olalla M, Fernández J, Cabrera C, Navarro M, Giménez R, López MC (2004) Nutritional study of copper and zinc in grapes and commercial grape juices from Spain. J Agric Food Chem 52:2715–2720
Verma Y, Rana S (2014) Assessment of cadmium, chromium, and copper levels in market fruit samples in Meerut, North India. Toxicol Environ Chem 96:1516–1522
Proshad R, Kormoker T, Islam MS, Hanif MA, Chandra K (2018) Chronic exposure assessment of toxic elements from agricultural soils around the industrial areas of Tangail District, Bangladesh. Arch Agric Environ Sci 3:317–336
Mielke HW, Gonzales CR, Smith MK, Mielke PW (1999) The urban environment and children’s health: soils as an integrator of lead, zinc, and cadmium in New Orleans, Louisiana, USA. Environ Res 81:117–129
Beamer P, Key ME, Ferguson AC, Canales RA, Auyeung W, Leckie JO (2008) Quantified activity pattern data from 6 to 27-month-old farmworker children for use in exposure assessment. Environ Res 108:239–246
Yang L, Ren Q, Zheng K, Jiao Z, Ruan X, Wang Y (2022) Migration of heavy metals in the soil-grape system and potential health risk assessment. Sci Total Environ 806:150646
Milićević T, AničićUrošević M, Relić D, Jovanović G, Nikolić D, Vergel K, Popović A (2021) Environmental pollution influence to soil–plant–air system in organic vineyard: bioavailability, environmental, and health risk assessment. Environ Sci Pollut Res 28:3361–3374
Milićević T, Urošević MA, Relić D, Vuković G, Škrivanj S, Popović A (2018) Bioavailability of potentially toxic elements in soil–grapevine (leaf, skin, pulp and seed) system and environmental and health risk assessment. Sci Total Environ 626:528–545
Acknowledgements
The authors would like to thank Professor Mehdi Zarrei in Sickkids Hospital in Toronto, Canada, and Mansoureh Farhang for valuable comments and suggestions, allowing us to improve this paper.
Funding
This research was supported by funds provided by Vice Chancellor for Research and Technology University of Medical Sciences, Iran.
Author information
Authors and Affiliations
Contributions
Conceptualization and study design: Roya Peirovi-Minaee and Ali Alami; review of literature and drafting: Ahmad Zarei and Roya Peirovi-Minaee; writing-review and editing: Ahmad Zarei and Alireza Moghaddam; field and laboratory work: Roya Peirovi-Minaee.
Corresponding author
Ethics declarations
Conflict of Interest
The authors declare no competing interests.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Peirovi-Minaee, R., Alami, A., Moghaddam, A. et al. Determination of Concentration of Metals in Grapes Grown in Gonabad Vineyards and Assessment of Associated Health Risks. Biol Trace Elem Res 201, 3541–3552 (2023). https://doi.org/10.1007/s12011-022-03428-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12011-022-03428-8