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Effects of Different Levels of Organic Trace Minerals on Oxidative Status and Intestinal Function in Weanling Piglets

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Abstract

An experiment was conducted to compare the effects of replacing inorganic trace minerals (ITM) with different levels of complex organic trace minerals (OTM) on the growth performance, oxidative status, and intestinal function of piglets. Weanling piglets were assigned to five groups: a control group fed a basal diet supplemented with inorganic trace minerals and the other four groups fed basal diets supplemented with different levels of OTMs. The results showed that diets supplemented with 50 ppm Fe, 30 ppm Zn, 15 ppm Mn, and 0.2 ppm Se from OTM (L-OTM), or with 75 ppm Fe, 45 ppm Zn, 22.5 ppm Mn, and 0.3 ppm Se from OTM (M-OTM) significantly decreased the diarrhea ratio in the piglets compared with those supplemented with 100 ppm Fe, 90 ppm Zn, 40 ppm Mn, and 0.4 ppm Se from ITM. Compared with those in the ITM group, the piglets in the M-OTM group had significantly higher serum CuZnSOD, MnSOD, and GSH-Px levels. Moreover, piglets in the L-OTM and M-OTM groups had higher Sod and Gpx gene expression than those in the ITM group. Additionally, piglets in the L-OTM and M-OTM groups had significantly higher villus height than those in the ITM group, and the M-OTM group piglets had lower serum diamine oxidase content and higher ileal ZO-1 and occludin protein expression levels than those in the ITM group. These results indicate that replacing dietary ITMs with OTMs could decrease diarrhea occurrence and improve the oxidative status and intestinal barrier function in weanling piglets.

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Data Availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Funding

This study was funded by “Huxiang Young Talents Plan” Project of Hunan Province (2019RS2046), China Agriculture Research System of MOF and MARA, and Youth Innovation Promotion Association CAS.

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Authors and Affiliations

  1. Changsha Xinjia Bio-Engineering Co., Ltd., Changsha, 410000, China

    Shangchu Wang, Shujun Wu, Yawei Zhang & Juan Chen

  2. Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, China

    Xihong Zhou

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  1. Shangchu Wang
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  2. Shujun Wu
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  3. Yawei Zhang
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  4. Juan Chen
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  5. Xihong Zhou
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Corresponding author

Correspondence to Xihong Zhou.

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The study was conducted according to the principles of the animal welfare committee of the Institute of Subtropical Agriculture, Chinese Academy of Sciences and was approved by the animal welfare committee of the Institute of Subtropical Agriculture, Chinese Academy of Sciences.

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Informed consent was obtained from all individual participants included in the study.

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Wang, S., Wu, S., Zhang, Y. et al. Effects of Different Levels of Organic Trace Minerals on Oxidative Status and Intestinal Function in Weanling Piglets. Biol Trace Elem Res 201, 720–727 (2023). https://doi.org/10.1007/s12011-022-03174-x

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  • DOI: https://doi.org/10.1007/s12011-022-03174-x

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