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Comparison of LPO-AOS Indices and Biochemical Composition of Animal Blood in Biogeochemical Provinces with Different Levels of Selenium

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Abstract

The paper aims to compare parameters of lipid peroxidation and antioxidant defense system, as well as blood biochemical composition in infertile cows from groups that differ in terms of selenium content in agrocoenosis. Forty-five black-motley and red-motley breeds in each region were selected for the experiment; the groups were formed on the basis of the pathology, 15 animals each. The level of microelements in the blood of animals from all groups in the selenium-deficient biogeochemical province is significantly reduced by 38.4–41.7% (P < 0.05). In these cows, the concentration of malondialdehyde increased significantly, by 1.5–2.1 times (P < 0.05), against the background of decrease in the activity of glutathione antioxidant defense: glutathione peroxidase by 9.4–32.1% (P < 0.05), glutathione reductase by 2.4–2.6 times (P < 0.05), also superoxide dismutase and catalase in some groups. In the groups of infertile animals with lowered selenium content in blood, the author found an increase in enzymes’ activity (P < 0.05): alanine aminotransferase by 25.6–52.6%, aspartate aminotransferase by 17.8% in cysts and by 44.3% in ovarian hypofunction, gamma-glutamyltransferase by 18.3% in ovarian hypofunction. In addition, the calcium content in the blood of cows was reduced by 8.1–14.0% (P < 0.05) when selenium levels were lowered. In combination with elevated levels of urea and urea/creatinine ratio, the above may be evidence of pathological processes in muscle, liver, and kidney tissues. Thus, the author traced the dependence of the balance of lipid peroxidation and antioxidant defense system on the microelement level, as well as the effect of low selenium provision of animals in biogeochemical provinces on the biochemical composition of their blood.

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This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Laboratory of Environment Biogeochemistry, Vernadsky Institute of Geochemistry and Analytical Chemistry, Moscow, Russia

    Vladimir Safonov

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  1. Vladimir Safonov
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Vladimir Safonov is the single author and he is the only one responsible to the content of the manuscript.

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Correspondence to Vladimir Safonov.

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All animal handling conformed to the humane treatment requirements for laboratory animals set out in Directive 2010/63/EC. The study was conducted in accordance with the ethical principles approved by the Ethics Committee of Vernadsky Institute of Geochemistry and Analytical Chemistry (Protocol № 2 of 14.03.2020).

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Informed consent for publication of the data was obtained from the owners of the farms located in the Voronezh and Kirov region.

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Safonov, V. Comparison of LPO-AOS Indices and Biochemical Composition of Animal Blood in Biogeochemical Provinces with Different Levels of Selenium . Biol Trace Elem Res 200, 2055–2061 (2022). https://doi.org/10.1007/s12011-021-02825-9

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