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Pharmacokinetics of Sodium Selenite Administered Orally in Blood and Tissues of Selenium-Deficient Ducklings

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Abstract

Selenium (Se) is an essential trace element for humans and animals. Appropriate amount of Se in the body can prevent a variety of diseases. However, Se deficiency leads to pathological changes such as skeletal muscle necrosis and pancreatic atrophy in livestock and poultry. Se preparations are widely used in the prevention and treatment of Se-deficient disease, but there is no unified standard of medication, and the safe dose range of Se is narrow. Therefore, it is of great significance to study the pharmacokinetics of low-Se ducklings and to formulate drug administration schemes. In the present study, eighty 1-day-old healthy ducklings were randomly selected, and fed with low-Se diet to 30 days of age (blood Se content ≦ 0.03 μg/mL). After the low Se duckling models were duplicated, blood samples and tissues of livers, pancreases, and thigh muscles were collected at different time points to detect Se content following oral administration of 0.1% sodium selenite (Na2SeO3) at 0.8 mg/kg BW, and the pharmacokinetics parameters were automatically calculated by MCPKP program. The results showed that pharmacokinetics characteristics of Na2SeO3 in blood, livers, and pancreases of ducklings were consistent with the first-order absorption and two-compartment open models; in thigh muscles was consistent with the first-order absorption and one compartment with a lag time open model. The primary kinetic parameters of Na2SeO3 in blood: the half-life of absorption was 5.9026 h, the time of reaching maximum concentration was 23.03 h, and the half-life of elimination was 131.13 h. The absorption of Na2SeO3 in livers was the quickest, pancreases and thigh muscles were in order of becoming slower, and the elimination of Na2SeO3 in thigh muscles was the quickest, livers and pancreases were in order of becoming slower. The administration parameters of multi-dose were calculated according to the kinetic of single-dose: loading dose (D*) was 1.7046 mg/kg BW, maintenance dose (D0) was 0.8 mg/kg BW, and dosing interval (τ) was 120 h. The results of this study can supplement and improve the theoretical system of Se metabolic kinetics, and provide experimental basis for the prevention and treatment of Se deficiency disease by rational drug use.

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References

  1. Khoso PA, Zhang Y, Yin H, Teng X, Li S (2018) Selenium deficiency affects immune function by influencing selenoprotein and cytokine expression in chicken spleen. Biol Trace Elem Res. https://doi.org/10.1007/s12011-018-1396-9

  2. Wang Y, Chen P, Zhao G, Sun K, Li D, Wan X, Zhang J (2015) Inverse relationship between elemental selenium nanoparticle size and inhibition of cancer cell growth in vitro and in vivo. Food Chem Toxicol 85:71–77. https://doi.org/10.1016/j.fct.2015.08.006

    Article  CAS  PubMed  Google Scholar 

  3. Gong T, Torres DJ, Berry MJ, Pitts MW (2018) Hypothalamic redox balance and leptin signaling - emerging role of selenoproteins. Free Radic Biol Med 127:172–181. https://doi.org/10.1016/j.freeradbiomed.2018.02.038

    Article  CAS  PubMed  Google Scholar 

  4. Sun X, Cui Y, Wang Q, Tang S, Cao X, Luo H, He Z, Hu X, Nie X, Yang Y, Wang T (2018) Proteogenomic analyses revealed favorable metabolism pattern alterations in rotifer Brachionus plicatilis fed with selenium-rich chlorella. J Agric Food Chem 66(26):6699–6707. https://doi.org/10.1021/acs.jafc.8b00139

    Article  CAS  PubMed  Google Scholar 

  5. Zheng S, Song H, Gao H, Liu C, Zhang Z, Fu J (2016) The antagonistic effect of selenium on lead-induced inflammatory factors and heat shock protein mRNA level in chicken cartilage tissue. Biol Trace Elem Res 173(1):177–184. https://doi.org/10.1007/s12011-016-0630-6

    Article  CAS  PubMed  Google Scholar 

  6. National Research Council (1998) Nutrient requirements of poultry, 10th edn. National Academy Press, Washington, DC

    Google Scholar 

  7. National Research Council (1998) Nutrient requirements of swine, 10th edn. National Academy Press, Washington, DC

    Google Scholar 

  8. Zheng SF, Bao RK, Zhang QJ, Wang SC, Lin HJ (2018) Endogenous hydrogen sulfide promotes apoptosis via mitochondrial pathways in the livers of broilers with selenium deficiency exudative diathesis disease. Biol Trace Elem Res 186:249–257. https://doi.org/10.1007/s12011-018-1292-3

    Article  CAS  PubMed  Google Scholar 

  9. Xu J, Wang L, Tang J, Jia G, Liu G, Chen X, Cai J, Shang H, Zhao H (2017) Pancreatic atrophy caused by dietary selenium deficiency induces hypoinsulinemic hyperglycemia via global down-regulation of selenoprotein encoding genes in broilers. PLoS One 12(8):e0182079. https://doi.org/10.1371/journal.pone.0182079

    Article  PubMed  PubMed Central  Google Scholar 

  10. Del Bas JM, Rodriguez B, Puiggros F, Marine S, Rodriguez MA, Morina D, Armengol L, Caimari A, Arola L (2017) Hepatic accumulation of S-adenosylmethionine in hamsters with non-alcoholic-fatty liver disease associated to metabolic syndrome under selenium and vitamin E deficiency. Clin Sci. https://doi.org/10.1042/CS20171039

  11. Oropeza-Moe M, Wisloff H, Bernhoft A (2015) Selenium deficiency associated porcine and human cardiomyopathies. J Trace Elem Med Biol 31:148–156. https://doi.org/10.1016/j.jtemb.2014.09.011

    Article  CAS  PubMed  Google Scholar 

  12. Sheppard AD, Blom L, Grant AB (1984) Levels of selenium in blood and tissues associated with some selenium deficiency diseases in New Zealand sheep. N Z Vet J 32(6):91–95. https://doi.org/10.1080/00480169.1984.35076

    Article  CAS  PubMed  Google Scholar 

  13. Surai PF, Fisinin VI (2015) Selenium in pig nutrition and reproduction: boars and semen quality-a review. Asian Australas J Anim Sci 28(5):730–746. https://doi.org/10.5713/ajas.14.0593

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Zhan X, Qie Y, Wang M, Li X, Zhao R (2011) Selenomethionine: an effective selenium source for sow to improve se distribution, antioxidant status, and growth performance of pig offspring. Biol Trace Elem Res 142(3):481–491. https://doi.org/10.1007/s12011-010-8817-8

    Article  CAS  PubMed  Google Scholar 

  15. Dubreil C, Sainte Catherine O, Lalatonne Y, Journe C, Ou P, van Endert P, Motte L (2018) Tolerogenic iron oxide nanoparticles in type 1 diabetes: biodistribution and pharmacokinetics studies in nonobese diabetic mice. Small 14:e1802053. https://doi.org/10.1002/smll.201802053

    Article  CAS  PubMed  Google Scholar 

  16. Su J, Sripanidkulchai K, Suksamrarn A, Hu Y, Piyachuturawat P, Sripanidkulchai B (2012) Pharmacokinetics and organ distribution of diarylheptanoid phytoestrogens from Curcuma comosa in rats. J Nat Med 66(3):468–475. https://doi.org/10.1007/s11418-011-0607-x

    Article  CAS  PubMed  Google Scholar 

  17. Wang X, Wang WX (2017) Selenium induces the demethylation of mercury in marine fish. Environ Pollut 231(Pt 2):1543–1551. https://doi.org/10.1016/j.envpol.2017.09.014

    Article  CAS  PubMed  Google Scholar 

  18. Szulc-Musiol B, Gadomska-Nowak M, Danch A, Ryszka F (2004) Pharmacokinetics of selenium following oral administration selenium preparation in rabbits. Boll Chim Farm 143(2):62–64

    CAS  PubMed  Google Scholar 

  19. Waldridge BM, Duran SH, Ravis WR, Paxton R, Herdt TH, Pugh DG (2004) Pharmacokinetics of subcutaneous selenium in adult llamas. Vet Ther 5(4):272–278

    PubMed  Google Scholar 

  20. Blodgett DJ, Bevill RF (1987) Pharmacokinetics of selenium administered parenterally at toxic doses in sheep. Am J Vet Res 48(3):530–534

    CAS  PubMed  Google Scholar 

  21. Ecimovic S, Velki M, Vukovic R, Stolfa Camagajevac I, Petek A, Bosnjakovic R, Grgic M, Engelmann P, Bodo K, Filipovic-Marijic V, Ivankovic D, Erk M, Mijosek T, Loncaric Z (2018) Acute toxicity of selenate and selenite and their impacts on oxidative status, efflux pump activity, cellular and genetic parameters in earthworm Eisenia andrei. Chemosphere 212:307–318. https://doi.org/10.1016/j.chemosphere.2018.08.095

    Article  CAS  PubMed  Google Scholar 

  22. Gobi N, Vaseeharan B, Rekha R, Vijayakumar S, Faggio C (2018) Bioaccumulation, cytotoxicity and oxidative stress of the acute exposure selenium in Oreochromis mossambicus. Ecotoxicol Environ Saf 162:147–159. https://doi.org/10.1016/j.ecoenv.2018.06.070

    Article  CAS  PubMed  Google Scholar 

  23. Zheng S, Jin X, Chen M, Shi Q, Zhang H, Xu S (2018) Hydrogen sulfide exposure induces jejunum injury via CYP450s/ROS pathway in broilers. Chemosphere 214:25–34. https://doi.org/10.1016/j.chemosphere.2018.09.002

    Article  CAS  PubMed  Google Scholar 

  24. Yang J, Zhang Y, Hamid S, Cai J, Liu Q, Li H, Zhao R, Wang H, Xu S, Zhang Z (2017) Interplay between autophagy and apoptosis in selenium deficient cardiomyocytes in chicken. J Inorg Biochem 170:17–25. https://doi.org/10.1016/j.jinorgbio.2017.02.006

    Article  CAS  PubMed  Google Scholar 

  25. Yao HD, Wu Q, Zhang ZW, Zhang JL, Li S, Huang JQ, Ren FZ, Xu SW, Wang XL, Lei XG (2013) Gene expression of endoplasmic reticulum resident selenoproteins correlates with apoptosis in various muscles of se-deficient chicks. J Nutr 143(5):613–619. https://doi.org/10.3945/jn.112.172395

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Niyo Y, Glock RD, Ramsey FK, Ewan RC (1977) Effects of intramuscular injections of selenium and vitamin E on selenium-vitamin E deficiency in young pigs. Am J Vet Res 38(10):1479–1484

    CAS  PubMed  Google Scholar 

  27. Fraga CG, Arias RF, Llesuy SF, Koch OR, Boveris A (1987) AEffect of vitamin E- and selenium-deficiency on rat liver chemiluminescence. Biochem J 242(2):383–386

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Zhao X, Yao H, Fan R, Zhang Z, Xu S (2014) Selenium deficiency influences nitric oxide and selenoproteins in pancreas of chickens. Biol Trace Elem Res 161(3):341–349. https://doi.org/10.1007/s12011-014-0139-9

    Article  CAS  PubMed  Google Scholar 

  29. Huang JQ, Li DL, Zhao H, Sun LH, Xia XJ, Wang KN, Luo X, Lei XG (2011) The selenium deficiency disease exudative diathesis in chicks is associated with downregulation of seven common selenoprotein genes in liver and muscle. J Nutr 141(9):1605–1610. https://doi.org/10.3945/jn.111.145722

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Haraya K, Tachibana T, Nezu J (2017) Quantitative prediction of therapeutic antibody pharmacokinetics after intravenous and subcutaneous injection in human. Drug Metab Pharmacokinet 32(4):208–217. https://doi.org/10.1016/j.dmpk.2017.05.002

    Article  CAS  PubMed  Google Scholar 

  31. Jastrzebski Z, Czyzewska-Szafran H, Remiszewska M, Fijalek Z, Fitak BA, Suchocki P (1997) Pharmacokinetics of selol, a new agent containing selenium, in rats. Drugs Exp Clin Res 23(1):7–11

    CAS  PubMed  Google Scholar 

  32. Guenter W, Bragg DB (1977) Response of broiler chick to dietary selenium. Poult Sci 56(6):2031–2038

    Article  CAS  PubMed  Google Scholar 

  33. Saito Y, Takahashi K (2002) Characterization of selenoprotein P as a selenium supply protein. Eur J Biochem 269(22):5746–5751. https://doi.org/10.1046/j.1432-1033.2002.03298.x

    Article  CAS  PubMed  Google Scholar 

  34. Zhao Z, Barcus M, Kim J, Lum KL, Mills C, Lei XG (2016) High dietary selenium intake alters lipid metabolism and protein synthesis in liver and muscle of pigs. J Nutr 146(9):1625–1633. https://doi.org/10.3945/jn.116.229955

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Lehr T, Narbe R, Jons O, Kloft C, Staab A (2010) Population pharmacokinetic modelling and simulation of single and multiple dose administration of meloxicam in cats. J Vet Pharmacol Ther 33(3):277–286. https://doi.org/10.1111/j.1365-2885.2009.01134.x

    Article  CAS  PubMed  Google Scholar 

  36. van Iersel M, Rossenu S, de Greef R, Waskin H (2018) A population pharmacokinetic model for a solid Oral tablet formulation of posaconazole. Antimicrob Agents Chemother 62(7). https://doi.org/10.1128/AAC.02465-17

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Funding

This study was supported by the International (Regional) Cooperation and Exchange Projects of the National Natural Science Foundation of China (31320103920).

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Authors and Affiliations

  1. College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, People’s Republic of China

    Shufang Zheng, Qiaojian Zhang & Shiwen Xu

  2. College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, People’s Republic of China

    Houjuan Xing

  3. National Selenium-Rich Products Quality Supervision and Inspection Center, Enshi, 445000, People’s Republic of China

    Hua Xue & Fating Zhu

  4. Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, People’s Republic of China

    Shiwen Xu

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  1. Shufang Zheng
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Correspondence to Shiwen Xu.

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Zheng, S., Xing, H., Zhang, Q. et al. Pharmacokinetics of Sodium Selenite Administered Orally in Blood and Tissues of Selenium-Deficient Ducklings. Biol Trace Elem Res 190, 509–516 (2019). https://doi.org/10.1007/s12011-018-1567-8

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