Abstract
Visceral adiposity is linked to the development of insulin resistance, which is a condition that may contribute to metabolic abnormalities and cardiovascular disease. Various minerals play essential roles in different metabolic functions in the body. Thus, the relationships between mineral concentrations in the hair and insulin resistance were analyzed in 144 Korean adults (71 viscerally obese subjects and 73 normal control subjects) in this cross-sectional study. Visceral obesity was measured using a bioelectrical impedance analysis (BIA), and insulin resistance levels were assessed using the homeostasis model assessment insulin resistance (HOMA-IR) index. The viscerally obese group exhibited significantly higher levels of serum glucose (96.5 vs 91.0 mg/dL, P = 0.023), insulin concentration (4.78 vs 2.98 μIU/mL, P = 0.003), and the HOMA-IR index (1.18 vs 0.64, P = 0.003) compared with the normal control group. After adjusting for age and sex, there was a positive correlation between copper levels in the hair and the HOMA-IR index in the viscerally obese group (r = 0.241, P = 0.046) whereas chromium and selenium levels in the hair were negatively correlated with the HOMA-IR index (r = −0.256, P = 0.034, and r = −0.251, P = 0.038, respectively). Thus, chromium and selenium levels in the hair of viscerally obese adults were inversely associated with insulin resistance, whereas copper levels in the hair were positively associated with insulin resistance. This suggests that the mineral status of viscerally obese adults might play a role in the development of insulin resistance.
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References
Bastien M, Poirier P, Lemieux I, Despres JP (2014) Overview of epidemiology and contribution of obesity to cardiovascular disease. Prog Cardiovasc Dis 56(4):369–381. doi:10.1016/j.pcad.2013.10.016
Joyal SV (2004) A perspective on the current strategies for the treatment of obesity. Curr Drug Targets CNS Neurol Disord 3(5):341–356
Patel P, Abate N (2013) Role of subcutaneous adipose tissue in the pathogenesis of insulin resistance. J Obes 2013:489187. doi:10.1155/2013/489187
Hayashi T, Boyko EJ, McNeely MJ, Leonetti DL, Kahn SE, Fujimoto WY (2008) Visceral adiposity, not abdominal subcutaneous fat area, is associated with an increase in future insulin resistance in Japanese Americans. Diabetes 57(5):1269–1275. doi:10.2337/db07-1378
Yudkin JS (2003) Adipose tissue, insulin action and vascular disease: inflammatory signals. Int J Obes Relat Metab Disord 27(Suppl 3):S25–S28. doi:10.1038/sj.ijo.0802496
Neeland IJ, Ayers CR, Rohatgi AK, Turer AT, Berry JD, Das SR, Vega GL, Khera A, McGuire DK, Grundy SM, de Lemos JA (2013) Associations of visceral and abdominal subcutaneous adipose tissue with markers of cardiac and metabolic risk in obese adults. Obesity (Silver Spring) 21(9):E439–E447. doi:10.1002/oby.20135
Ren XH, Yao YS, He LP, Jin YL, Chang WW, Li J, Chen Y, Song XL, Tang H, Ding LL, Guo DX, Li CP (2013) Overweight and obesity associated with increased total serum calcium level: comparison of cross-sectional data in the health screening for teaching faculty. Biol Trace Elem Res 156(1–3):74–78. doi:10.1007/s12011-013-9856-8
Byyny RL, LoVerde M, Lloyd S, Mitchell W, Draznin B (1992) Cytosolic calcium and insulin resistance in elderly patients with essential hypertension. Am J Hypertens 5(7):459–464
Corica F, Corsonello A, Ientile R, Cucinotta D, Di Benedetto A, Perticone F, Dominguez LJ, Barbagallo M (2006) Serum ionized magnesium levels in relation to metabolic syndrome in type 2 diabetic patients. J Am Coll Nutr 25(3):210–215
Huerta MG, Roemmich JN, Kington ML, Bovbjerg VE, Weltman AL, Holmes VF, Patrie JT, Rogol AD, Nadler JL (2005) Magnesium deficiency is associated with insulin resistance in obese children. Diabetes Care 28(5):1175–1181
Vanaelst B, Huybrechts I, Michels N, Florez MR, Aramendia M, Balcaen L, Resano M, Vanhaecke F, Bammann K, Bel-Serrat S, De Henauw S (2013) Hair minerals and metabolic health in Belgian elementary school girls. Biol Trace Elem Res 151(3):335–343. doi:10.1007/s12011-012-9573-8
Suliburska J, Bogdanski P, Pupek-Musialik D, Krejpcio Z (2011) Dietary intake and serum and hair concentrations of minerals and their relationship with serum lipids and glucose levels in hypertensive and obese patients with insulin resistance. Biol Trace Elem Res 139(2):137–150. doi:10.1007/s12011-010-8650-0
Suliburska J, Cofta S, Gajewska E, Kalmus G, Sobieska M, Samborski W, Krejpcio Z, Drzymala-Czyz S, Bogdanski P (2013) The evaluation of selected serum mineral concentrations and their association with insulin resistance in obese adolescents. Eur Rev Med Pharmacol Sci 17(17):2396–2400
Olusi S, Al-Awadhi A, Abiaka C, Abraham M, George S (2003) Serum copper levels and not zinc are positively associated with serum leptin concentrations in the healthy adult population. Biol Trace Elem Res 91(2):137–144. doi:10.1385/bter:91:2:137
Guo CH, Chen PC, Ko WS (2013) Status of essential trace minerals and oxidative stress in viral hepatitis C patients with nonalcoholic fatty liver disease. Int J Med Sci 10(6):730–737. doi:10.7150/ijms.6104
Kazi TG, Afridi HI, Kazi N, Jamali MK, Arain MB, Jalbani N, Kandhro GA (2008) Copper, chromium, manganese, iron, nickel, and zinc levels in biological samples of diabetes mellitus patients. Biol Trace Elem Res 122(1):1–18. doi:10.1007/s12011-007-8062-y
Abou-Seif MA, Youssef AA (2004) Evaluation of some biochemical changes in diabetic patients. Clin Chim Acta int J Clin Chem 346(2):161–170. doi:10.1016/j.cccn.2004.03.030
Campbell JD (2001) Lifestyle, minerals and health. Med Hypotheses 57(5):521–531. doi:10.1054/mehy.2001.1351
Basaki M, Saeb M, Nazifi S, Shamsaei HA (2012) Zinc, copper, iron, and chromium concentrations in young patients with type 2 diabetes mellitus. Biol Trace Elem Res 148(2):161–164. doi:10.1007/s12011-012-9360-6
Chung JH, Yum KS (2012) Correlation of hair mineral concentrations with insulin resistance in Korean males. Biol Trace Elem Res 150(1–3):26–30. doi:10.1007/s12011-012-9474-x
Klevay LM, Bistrian BR, Fleming CR, Neumann CG (1987) Hair analysis in clinical and experimental medicine. Am J Clin Nutr 46(2):233–236
Levine JA, Abboud L, Barry M, Reed JE, Sheedy PF, Jensen MD (2000) Measuring leg muscle and fat mass in humans: comparison of CT and dual-energy X-ray absorptiometry. J Appl Physiol (Bethesda, MD: 1985) 88(2):452–456
Karlsson AK, Kullberg J, Stokland E, Allvin K, Gronowitz E, Svensson PA, Dahlgren J (2013) Measurements of total and regional body composition in preschool children: a comparison of MRI, DXA, and anthropometric data. Obesity (Silver Spring) 21(5):1018–1024. doi:10.1002/oby.20205
Malavolti M, Mussi C, Poli M, Fantuzzi AL, Salvioli G, Battistini N, Bedogni G (2003) Cross-calibration of eight-polar bioelectrical impedance analysis versus dual-energy X-ray absorptiometry for the assessment of total and appendicular body composition in healthy subjects aged 21–82 years. Ann Hum Biol 30(4):380–391. doi:10.1080/0301446031000095211
Lintsi M, Kaarma H, Kull I (2004) Comparison of hand-to-hand bioimpedance and anthropometry equations versus dual-energy X-ray absorptiometry for the assessment of body fat percentage in 17–18-year-old conscripts. Clin Physiol Funct Imaging 24(2):85–90. doi:10.1111/j.1475-097X.2004.00534.x
Fakhrawi DH, Beeson L, Libanati C, Feleke D, Kim H, Quansah A, Darnell A, Lammi-Keefe CJ, Cordero-MacIntyre Z (2009) Comparison of body composition by bioelectrical impedance and dual-energy X-ray absorptiometry in overweight/obese postmenopausal women. J Clin Densitom 12(2):238–244. doi:10.1016/j.jocd.2009.01.004
Anderson LJ, Erceg DN, Schroeder ET (2012) Utility of multifrequency bioelectrical impedance compared with dual-energy X-ray absorptiometry for assessment of total and regional body composition varies between men and women. Nutr Res 32(7):479–485. doi:10.1016/j.nutres.2012.05.009
Lim S, Choi SH, Park YJ, Park KS, Lee HK, Jang HC, Cho NH, Metzger BE (2007) Visceral fatness and insulin sensitivity in women with a previous history of gestational diabetes mellitus. Diabetes care 30(2):348–353. doi:10.2337/dc06-1405
Okauchi Y, Kishida K, Funahashi T, Noguchi M, Ogawa T, Ryo M, Okita K, Iwahashi H, Imagawa A, Nakamura T, Matsuzawa Y, Shimomura I (2010) Absolute value of bioelectrical impedance analysis-measured visceral fat area with obesity-related cardiovascular risk factors in Japanese workers. J Atheroscler Thromb 17(12):1237–1245
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28(7):412–419
Nakamura K, Fuster JJ, Walsh K (2013) Adipokines: a link between obesity and cardiovascular disease. J Cardiol. doi:10.1016/j.jjcc.2013.11.006
Sanip Z, Ariffin FD, Al-Tahami BA, Sulaiman WA, Rasool AH (2013) Obesity indices and metabolic markers are related to hs-CRP and adiponectin levels in overweight and obese females. Obes Res Clin Pract 7(4):e235–e320. doi:10.1016/j.orcp.2012.05.002
Lehrke M, Broedl UC, Biller-Friedmann IM, Vogeser M, Henschel V, Nassau K, Goke B, Kilger E, Parhofer KG (2008) Serum concentrations of cortisol, interleukin 6, leptin and adiponectin predict stress induced insulin resistance in acute inflammatory reactions. Crit Care 12(6):R157. doi:10.1186/cc7152
Brochu M, Mathieu ME, Karelis AD, Doucet E, Lavoie ME, Garrel D, Rabasa-Lhoret R (2008) Contribution of the lean body mass to insulin resistance in postmenopausal women with visceral obesity: a Monet study. Obesity (Silver Spring, Md) 16(5):1085–1093. doi:10.1038/oby.2008.23
Mertz W (1969) Chromium occurrence and function in biological systems. Physiol Rev 49(2):163–239
Vincent JB (2003) The potential value and toxicity of chromium picolinate as a nutritional supplement, weight loss agent and muscle development agent. Sports Med (Auckland, NZ) 33(3):213–230
Stupar J, Vrtovec M, Dolinsek F (2007) Longitudinal hair chromium profiles of elderly subjects with normal glucose tolerance and type 2 diabetes mellitus. Metab Clin Exp 56(1):94–104. doi:10.1016/j.metabol.2006.09.003
Wiechula D, Loska K, Ungier D, Fischer A (2012) Chromium, zinc and magnesium concentrations in the pubic hair of obese and overweight women. Biol Trace Elem Res 148(1):18–24. doi:10.1007/s12011-012-9339-3
Chen QL, Luo Z, Liu X, Song YF, Liu CX, Zheng JL, Zhao YH (2013) Effects of waterborne chronic copper exposure on hepatic lipid metabolism and metal-element composition in Synechogobius hasta. Arch Environ Contam Toxicol 64(2):301–315. doi:10.1007/s00244-012-9835-7
Rayman MP (2000) The importance of selenium to human health. Lancet 356(9225):233–241. doi:10.1016/s0140-6736(00)02490-9
Beaglehole R, Jackson R, Watkinson J, Scragg R, Yee RL (1990) Decreased blood selenium and risk of myocardial infarction. Int J Epidemiol 19(4):918–922
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Kim, HN., Song, SW. Concentrations of Chromium, Selenium, and Copper in the Hair of Viscerally Obese Adults are Associated with Insulin Resistance. Biol Trace Elem Res 158, 152–157 (2014). https://doi.org/10.1007/s12011-014-9934-6
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DOI: https://doi.org/10.1007/s12011-014-9934-6